wild

2-Tridecanone is a volatile non-alkaloid insecticide isolated from the wild tomato Lycopersicon hirsutum f. glabratum.

Rhizoferrin TFA is a protein secreted by Legionella pneumophila that is an iron carrier and can induce cytokine production, promote Fe(3+) uptake by wild-type Legionella pneumophila, and promote the growth of iron-deficient bacteria.

Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.

Methyl 2-(1H-indol-3-yl)acetate (Methyl indole-3-acetate) is found in apple and isolated from immature seeds of beach pea (Lathyrus maritimus), Vicia amurensis, wild soybean (Glycine soja), lobiya (Vigna catiang var. sinensis), and hyacinth bean (Dolichos lablab).

Octyl acetate (Acetic acid octyl ester) is the acetate ester of octan-1-ol. It has a role as a plant metabolite.Acetic acid octyl ester is present in citrus peel oils.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.

7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.

Scoparone (Aesculetin dimethyl ether) can be found in a number of food items such as sweet orange, wild celery, mandarin orange (clementine, tangerine), and lemon. It is found in the Chinese herb Artemisia scoparia and has been studied for its potential pharmacological properties including immunosuppression and vasorelaxation. Scoparone is found in anise. Scoparone is found in several citrus oils.

Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4 8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).

Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.

Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.

4,6-O-Ethylidene-α-D-glucose (Ethylidene-glucose), a derivative of glucose, serves as a competitive inhibitor for the exofacial binding site of glucose transporter 1 (GLUT1), exhibiting a Ki of 12 mM against wild-type 2-deoxy-D-glucose transport.

CI-39, a natural antiviral product, serves as a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting wild type HIV-1. It exhibits an effective concentration (EC50) of 3.40 µM against the virus, while its cytotoxic concentration (CC50) exceeds 30 µM. This compound notably impedes HIV-1 reverse transcriptase (RT) DNA polymerase and ribonuclease H activities[1].

Ganglioside GM1 is one of the major sphingolipids (GSLs) on the cell surface of the central nervous system (CNS), which is protective of the CNS and is used in the study of neurological disorders.Ganglioside GM1 exerts protection against glutamate excitotoxicity through its oligosaccharides in wild-type and amyotrophic lateral sclerosis motor neurons.

6-Hydroxykaempferol 7-O-β-glucopyranoside (compound 5), a flavonol, has been isolated from the plant Tagetes minuta (wild marigold) [1].

6,7-Dimethoxy-2-(2-phenylethyl)chromone (6,7-Dimethoxy-2-phenethylchromone) is a substance found in incense wood and can be used as a metabolic marker to discriminate between wild and cultivated incense.

Luteolin 5-O-glucoside, a natural flavonoid, inhibit LPS-induced NO production and t-BHP-induced ROS production in wild-type 264.7 cells, and iNOS and COX-2 expression in macrophages.

Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul

1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains.
2. Shizukaol C has significant cytotoxicities against C8166 cells.

Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β STAT1 pathw

Glucobrassicin (potassium), a glucosinolate (GSL) derived from wild carrot (Raphanus raphanistrum L.), is utilized in biological fumigation and allelopathy studies for weed control [1].

(–)-Voacangarine, an indole alkaloid isolated from V. africana, exhibits cytotoxicity towards various cell lines including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 values of 20 µg/ml. Additionally, it demonstrates cytostatic effects on wild-type S. cerevisiae and is cytotoxic to Δrad3-e5 and Δrad6-1 mutant strains of S. cerevisiae, which have defects in DNA strand break repair and the mutagenic repair pathway, respectively.

Heronamide C, a polyketide macrolactam antifungal agent synthesized by marine Actinomycetes, exhibits selective toxicity by inhibiting growth and promoting abnormal cell wall material accumulation in wild-type fission yeast cells (MIC = 0.13-0.28 μM), without affecting Gram-positive bacteria or human cancer cell lines, HeLa and MDA-MB-231. At 20 μM, it triggers reversible morphological alterations, notably the development of large intracellular structures, in HeLa cells.

Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone isolated from the plasma membrane of wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Cryptomeria cepacia that mediates electron transfer in the aerobic respiratory chain and reduces oxidative stress.