Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Tag
  • GST
    (2)
  • His
    (2)
  • Tag Free
    (2)
  • C-Myc
    (1)
  • N-10xHis-SUMO
    (1)
TargetMol | Tags By Expression System
  • Baculovirus Insect Cells
    (3)
  • E. coli
    (2)
TargetMol | Tags By Species
  • Human
    (4)
  • Cynomolgus
    (1)
TargetMol | Tags By SPR-compatible Buffer
  • Buffer exchange required
    (5)
Filter
Search Result
Results for "

usp7

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    44
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    3
    TargetMol | PROTAC
  • Recombinant Protein
    5
    TargetMol | Recombinant_Protein
  • Antibody Products
    4
    TargetMol | Antibody_Products
TargetMolTargetMolCompare
USP7 Protein, Human, Recombinant (aa 208-560, His & GST)
ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
TMPY-01463
Expression system: Baculovirus Insect Cells
Length: 208-560, Partial
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
QTY
TargetMolTargetMolCompare
USP7 Protein, Human, Recombinant (aa 208-560)
ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
TMPY-01464
Expression system: Baculovirus Insect Cells
Length: 208-560, Partial
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
QTY
TargetMolTargetMolCompare
USP7 Protein, Human, Recombinant (His & GST)
ubiquitin specific peptidase 7 (herpes virus-associated), TEF1, HAUSP
TMPY-01465
Expression system: Baculovirus Insect Cells
Length: 1-1102, Full Length
Activity: Not Tested
  • Inquiry Price
7-10 days
Size
QTY
TargetMolTargetMolCompare
p53 Protein, Cynomolgus, Recombinant
tumor protein p53, TP53, p53
TMPY-02228
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitin ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further modifications such as methylation and acetylation lead to an increase in Tp53 binding to gene specific response elements. Tp53 regulates a large number of genes (>100 genes) that control a number of key tumor suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Defects in TP53 are a cause of esophageal cancer, Li-Fraumeni syndrome, lung cancer and adrenocortical carcinoma.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
  • Inquiry Price
7-10 days
Size
QTY