tryptophan

o-Nitrophenylsulfenyl-lysyl-tryptophan is a bioactive chemical.

L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of INDOLE ALKALOIDS in plants. It can be a precursor to NIACIN, although inefficiently in mammals.

L-5-BromoTryptophan (5-BrW) is an analog of the tryptophan (Trp) effector and inhibits the gelation of hemoglobin S.

DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.

N-Valyltryptophan (Val-trp) is an incomplete breakdown product of protein catabolism or protein digestion.

N-Acetyl-L-tryptophan (N-acetyltryptophan) is an inhibitor of neurokinin 1 receptor (NK1-receptor, NK1R).

5-Fluoro-L-tryptophan is a competitive inhibitor of the vesicular glutamate transporter (VGLUT). It holds potential for research related to disorders involving neurotransmitter systems.

Methionyl-Tryptophan is a dipeptide composed of methionine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism.

5-Methoxy-DL-tryptophan is a molecule produced by endothelial cells to modulate inflammatory responses and protect against systemic inflammation.

Tryptophan, N-indol-3-ylacetyl- (Indole-3-acetyl-L-tryptophan) is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may also be used in the synthesis of β-D-galactosidase and β-D-glucosidase inhibitors.

6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis.

L-5-Hydroxytryptophan (Standard) is a reference standard for research and analysis in studies involving L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP) is a naturally occurring amino acid and dietary supplement that serves as a precursor to the neurotransmitter serotonin. It can be used as an antidepressant, appetite suppressant, and sleep aid, and acts as an antagonist to reserpine. L-5-HTP is widely used in research on myoclonus, fibromyalgia, migraine, and cerebellar ataxia, and is also commonly used to induce epilepsy models.

DL-Tryptophan (Standard) is the standard substance of DL-Tryptophan, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Low thalamic Tryptophan uptake appears to be a strong, independent predictor of long survival in patients with previous glioma treatment.

L-Tryptophan-13C (Standard) is a reference standard of L-Tryptophan-13C intended for quantitative analysis, quality control, and related biochemical research applications. L-Tryptophan-13C is a form of L-Tryptophan that is labeled with 13C. L-Tryptophan (Tryptophan) is an essential amino acid and serves as a precursor to serotonin, melatonin, and vitamin B3.

5-Hydroxy-L-Tryptophan-4,6,7-D3 (Standard) is a reference standard of 5-Hydroxy-L-Tryptophan-4,6,7-D3 intended for quantitative analysis, quality control, and related biochemical research applications. 5-Hydroxy-L-tryptophan-4,6,7-d3 is L-5-Hydroxytryptophan labeled with 2H. L-5-Hydroxytryptophan (L-5-HTP) is a dietary supplement and a precursor to serotonin, which inhibits the IFN-γ induced PD-L1 expression. It promotes anti-tumor immunity and is used in research on migraine and depression.

Dl-Tryptophan-D3 (Standard) is a reference standard of Dl-Tryptophan-D3 intended for quantitative analysis, quality control, and related biochemical research applications. DL-Tryptophan-d3 is the deuterated form of DL-Tryptophan. DL-Tryptophan serves as an endogenous metabolite.

L-Tryptophan-D5 (Standard) is a reference standard of L-Tryptophan-D5 intended for quantitative analysis, quality control, and related biochemical research applications. L-Tryptophan-d5 is the deuterated form of L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid and serves as a precursor to serotonin, melatonin, and vitamin B3.

N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).

Indoximod (NLG-8189) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].

Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P

Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine(CP-10188) acts pharmacologically to deplete endogenous levels of serotonin.

pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.

H-D-Trp-OH (D-Tryptophan) is one of the 20 standard amino acids. The D-stereoisomer is occasionally found in naturally produced peptides (e.g. contryphan, the marine venom peptide).