thiol-groups

N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent that introduces thiol-groups into protein molecules and adds sulfhydryl groups in a protected form to proteins and other amine-containing molecules for later reaction with sulfhydryl reactive crosslinkers such as Sulfo-SMCC, Sulfo-MBS, etc.

DTNB (Ellman's Reagent) is used to quantify thiol groups in a sample and measure low-molecular-mass thiols, such as glutathione, in pure solutions and biological samples [such as blood].

DM3 (Maytansinoid DM3) is a maytansine mimic with disulfide or thiol groups, acting as a tubulin inhibitor and serving as the cytotoxic component in antibody-drug conjugates (ADCs).

DTE (Dithioerythritol) is a sulfur-containing sugar derivative of the four-carbon monosaccharide erythrose and is an epimer of dithiothreitol (DTT), Dithioerythritol (DTE) is commonly used as a reducing agent in biochemical and molecular biology experiments to maintain thiol groups in a reduced state, stabilize protein structure, and support redox-sensitive enzymatic and structural studies.

Nitrosobiotin [4-keto-4-(6-(5-(311-(3,5-dihydroxyphenyl)-balanyl)-1-tetrahydro-2H-thiopyran-3-yl)amino)-2,4,6trihydroxyphen-1-yl]-is a cyclic monomeric lactone. It contains three carbonyl groups (one on each carbon) but without ethanol functionalities to connect a third thiol group.

MTSES sodium (Sodium (2-Sulfonatoethyl)methanethiosulfonate) is a negatively charged, membrane-impermeable methanethiosulfonate (MTS). This MTS compound can react with thiol groups to form mixed disulfides, frequently utilized in studying cysteine residues on proteins.

TCO4-PEG2-Maleimide, a PEG-based PROTAC linker, features TCO and Maleimide groups that enable specific "click" reactions with tetrazine groups or react with thiol groups through "thiol-ene" reactions.

TCO4-PEG2-Maleimide is a PROTAC linker classified under the PEG category. This compound features TCO and Maleimide groups, enabling it to participate in specific "click" reactions with tetrazine groups or "thiol-maleimide" reactions with thiol groups.

TCO4-PEG7-Maleimide is a PROTAC linker from the PEG class. This compound includes TCO and Maleimide groups, which can specifically engage in "click" reactions with tetrazine groups or in "thiol-maleimide" reactions with thiol groups.

TCO4-PEG3-Maleimide is a PROTAC linker of the PEG class. It contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, respectively, or participate in "thiol-Michael" addition.

TCO4-PEG3-Maleimide is a PROTAC linker from the PEG category. It incorporates TCO and Maleimide groups, which can selectively undergo "click" reactions with tetrazine groups or react with thiol groups through a "thiol-maleimide" reaction.

Thiol-C2-PEG2-OH is a PEG-type PROTAC linker for PROTAC molecule synthesis.

Azido-PEG4-Thiol is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. As a click chemistry reagent, it possesses an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

L-Cysteic acid is an endogenous metabolite and the oxidation product of L-cysteine, where the thiol group is completely oxidised to sulfonic acid/sulfonic acid groups, and can serve as a substrate for GADCase, with a Km of 5.4 mM.

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.

Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

p-Aminophenylmercuric acetate (APMA) is an organic mercury compound and thiol-blocking agent commonly employed as an activator of MMPs (matrix metalloproteinases), capable of modulating cysteine-zinc ion interactions. APMA also induces platelet aggregation activation/inhibition in a dose-dependent manner.

QM295 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) characterized by its selectively reversible thiol reactivity. ERO1 is a key enzyme in the endoplasmic reticulum of eukaryotic cells responsible for catalyzing disulfide bond formation, which is essential for proper protein folding. QM295 inhibits ERO1 activity by interacting with specific thiol groups. It serves as an effective pharmacological tool for investigating endoplasmic reticulum stress (ER stress) and the mechanisms of oxidative protein folding.

Biotin-PEG7-Maleimide is a biotinylated biochemical assay reagent, which can be used as a thiol-specific probe. Cysteine-linked ADCs prepared with N-aryl maleimides exhibit less than 20% deconjugation in thiol-containing buffer Cysteine-linked ADCs prepared with N-aryl maleimides therefore markedly enhanced stability when compared with analogous ADCs prepared using N-alkyl maleimides, which undergo 35–67% deconjugation under identical conditions. Cysteine-linked ADCs prepared with N-aryl maleimides and incorporating the anticancer drug N-phenyl maleimide monomethyl-auristatin-E (MMAE) maintain strong cytotoxicity following prolonged serum exposure, whereas N-alkyl maleimide MMAE ADCs progressively lose potency.

N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol serves as a cleavable 4 unit PEG ADC linker in the preparation of antibody-drug conjugates (ADCs) [1]. This compound functions as a click chemistry reagent, equipped with an Azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain DBCO or BCN groups.

N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is an ADC linker that integrates four PEG units and is used in creating antibody-drug conjugates (ADCs) [1]. This compound functions as a click chemistry reagent possessing an Alkyne group, which enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.

Thiol-PEG3-thiol (Bis-PEG3-thiol) is a crosslinker with thiol groups employed in the synthesis of PEG hydrogels.

Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing the maleimide group. With its maleimide functional group, this compound is utilized for conjugating biomolecules that contain thiol groups.