thiol-groups

N-Succinimidyl-S-acetylthioacetate (SATA) is a protein modification agent that introduces thiol-groups into protein molecules and adds sulfhydryl groups in a protected form to proteins and other amine-containing molecules for later reaction with sulfhydryl reactive crosslinkers such as Sulfo-SMCC, Sulfo-MBS, etc.

DTNB (Ellman's Reagent) is used to quantify thiol groups in a sample and measure low-molecular-mass thiols, such as glutathione, in pure solutions and biological samples [such as blood].

DM3 (Maytansinoid DM3) is a maytansine mimic with disulfide or thiol groups, acting as a tubulin inhibitor and serving as the cytotoxic component in antibody-drug conjugates (ADCs).

Nitrosobiotin [4-keto-4-(6-(5-(311-(3,5-dihydroxyphenyl)-balanyl)-1-tetrahydro-2H-thiopyran-3-yl)amino)-2,4,6trihydroxyphen-1-yl]-is a cyclic monomeric lactone. It contains three carbonyl groups (one on each carbon) but without ethanol functionalities to connect a third thiol group.

MTSES sodium (Sodium (2-Sulfonatoethyl)methanethiosulfonate) is a negatively charged, membrane-impermeable methanethiosulfonate (MTS). This MTS compound can react with thiol groups to form mixed disulfides, frequently utilized in studying cysteine residues on proteins.

Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media.

Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Biotin-PEG7-Maleimide is a biotinylation agent that selectively binds to thiol (SH) groups and is used in synthesizing Drug-Linker Conjugates for Antibody-Drug Conjugates (ADCs) [1].

N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol serves as a cleavable 4 unit PEG ADC linker in the preparation of antibody-drug conjugates (ADCs) [1]. This compound functions as a click chemistry reagent, equipped with an Azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain DBCO or BCN groups.

N,N-Bis(PEG2-alkyne)-N-amido-PEG2-thiol is an ADC linker that integrates four PEG units and is used in creating antibody-drug conjugates (ADCs) [1]. This compound functions as a click chemistry reagent possessing an Alkyne group, which enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.

Thiol-PEG3-thiol (Bis-PEG3-thiol) is a crosslinker with thiol groups employed in the synthesis of PEG hydrogels.

Poly(ethylene glycol) methyl ether maleimide (Mn 2000) is a polyethylene glycol containing the maleimide (HY-W007324) group. With its maleimide functional group, this compound is utilized for conjugating biomolecules that contain thiol groups.

Dansylamidoethyl mercaptan is a molecule that reacts with the -SH groups of proteins and other thiol-containing molecules, and it is active in detecting disulfide bonds (S-S) in proteins.

Glutaraldehyde solution, 50% in H2O, is a solution consisting of 50% glutaraldehyde in water, often employed for cell fixation in staining experiments. Glutaraldehyde forms covalent bonds with nucleophilic groups such as amino and thiol groups in proteins, leading to irreversible cross-linking of intracellular proteins and effectively fixing cells. It stabilizes cell morphology and structure, facilitating subsequent observation and research. Additionally, glutaraldehyde solution can serve as a sterilizing agent, food processing aid, disinfectant, tanning agent, and wood preservative.

Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a large, membrane-impermeable, thiol-containing reagent, suitable for biotin labeling (such as sulfhydryl groups) and for protein or other biomolecule detection.

6-Maleimidocaproic acid hydrazide (N-ε-maleimidocaproic acid hydrazi) TFA is a maleimide derivative and serves as a heterobifunctional crosslinker that is reactive towards carbonyl and thiol groups.