sw-2

SW-2 is an bioactive chemical.

SW209049 is a stearoyl-CoA 9-desaturase inhibitor. SW209049 exhivits potent activity against H2122 cell with IC50 of 0.13uM.

P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor of P-glycoprotein (P-gp) and cyclin-dependent kinase 2 (CDK2). It inhibits the proliferation of cancer cell lines SW-480 and MCF-7, with IC50 values of 38.6 μM and 26.6 μM, respectively. In the DPPH assay, P-gp/CDK2-IN-1 demonstrates antioxidant activity with an EC50 of 580 μM.

SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM, exhibiting antidepressant-like activity and being researched for potential application in Alzheimer's disease (AD) treatment.

2-Hydroxymethyltetrahydropyran is a volatile compound found in the seed oil of Sambucus williamsii (SW) and exhibits promising antioxidant activity.

Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].