Search Result

Search Results for " superoxide "

100

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T78346	Superoxide dismutase	SOD
	Superoxide dismutase (SOD), an exclusive antioxidant enzyme, catalyzes the dismutation of the superoxide anion into oxygen and hydrogen peroxide, averting peroxynitrite formation and subsequent harm. It is extensively st...
T40612	Manganese(salen) chloride	EUK-8	Others
	Manganese(salen) chloride (EUK-8) (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates a...		Others
T8531	M-3M3FBS		Apoptosis , Phospholipase
	m-3M3FBS is a phospholipase C (PLC) activator.		Apoptosis , Phospholipase
T19930	Nitrosoglutathione	S-Nitrosoglutathione,SNOG,Glutathione thionitrite,GSNO	RAAS , NO Synthase
	Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, i...		RAAS , NO Synthase
T2686	Esomeprazole Magnesium	(S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium	ATPase , Proton pump
	Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block...		ATPase , Proton pump
T6495	EUK-134	EUK 134	Beta Amyloid
	EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.		Beta Amyloid
T8386	Esomeprazole Magnesium trihydrate	(S)-Omeprazole magnesium trihydrate	Proton pump
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagit...		Proton pump
T19428	Mito-TEMPO		Reactive Oxygen Species , Mitochondrial Metabolism
	Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO scavenges superoxide and alkyl radicals and prevents mitochondrial oxidation, necrosis and apoptosis.		Reactive Oxygen Species , Mitochondrial Metabolism
T75342	MitoSOX Red		Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
	MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superoxide upon entry into the mitochondria and is not oxidized by...
T2021	Dihydroethidium	PD-MY 003,Hydroethidine	Others
	Dihydroethidium (PD-MY 003) is a superoxide indicator.		Others
T6699	Tempol	TMPN,Tanol,4-Hydroxy-TEMPO	Reactive Oxygen Species , ROS , Autophagy
	Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.		Reactive Oxygen Species , ROS , Autophagy
T19668	Tiomolibdate diammonium	Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,Coprexa	Others
	Tiomolibdate diammonium (NSC-286644) is an inhibitor of superoxide dismutase 1 (SOD1) exerting antiangiogenic and antitumor activities. Tiomolibdate diammonium inhibits the activities of cuproenzymes, including SOD1 and ...		Others
T19023	Lucigenin	NSC-151912,L-6868	Others
	Lucigenin (NSC-151912) (L-6868) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells.		Others
T40795	BNTA		Reactive Oxygen Species
	BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxid...		Reactive Oxygen Species
T14133	AEOL-10150 pentachloride		Others
	AEOL-10150 pentachloride is a metalloporphyrin catalytic antioxidant. AEOL-10150 pentachloride also is a superoxide dismutase mimetic. Which protects lungs from radiation-induced injury.		Others
TP2321L	H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate	H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate（159147-88-3 free base)	Others
	H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate acts as antioxidant by reacting with active oxygen species such as superoxide and hydroxyl radicals.		Others
T5426	DMNQ		Reactive Oxygen Species , ROS
	DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS generation		Reactive Oxygen Species , ROS
TP1915	Boc-MLF		Others
	Antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.		Others
T14341	ATN-224	Bis(choline)tetrathiomolybdate	Others
	ATN-224 (Bis(choline)tetrathiomolybdate) inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5±3.7 nM. ATN-224 is an oral Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor.		Others
T19032	Nitro blue tetrazolium chloride	NBT	NO Synthase
	Nitro blue tetrazolium chloride (NBT) is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 M). A well-known scavenger of superoxide anions.Nitro blue tetrazolium chloride, a subst...		NO Synthase
T33412	MitoPQ	MitoParaquat	Glucokinase , transporter
	MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of...		Glucokinase , transporter
T20067	WST-1	WST 1
	WST-1 is a cytotoxic, water-soluble tetrazolium salt that induces intracellular mitochondrial dehydrogenases to undergo NADH-dependent enzymatic reactions, releasing water-soluble methylbenzene products.WST-1 can be used...
T7575L1	[Sar1, Ile8]-Angiotensin II acetate		RAAS
	[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascu...		RAAS
T22739	DMPO	5,5-Dimethyl-1-pyrroline N-oxide	Others
	DMPO (5,5-Dimethyl-1-pyrroline N-oxide) is a kind of water-soluble nitric oxide spin trap, which allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin reson...		Others
T39965	NF-κΒ activator 1		NF-κB
	NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide ...		NF-κB
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T20094	Adrenochrome	Adraxone	Antioxidant
	Adrenochrome (Adraxone) is a cytotoxic molecule that can be used to kill bacteria. Adrenochrome is an oxidized product of Epinephrine. Adrenochrome is a coronary systolic compound that acts on rat hearts and is associate...		Antioxidant
T38164	MnTBAP chloride	Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory ...
T7037	7-Acetoxy-4-methylcoumarin	MU-Ac	Others
	7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media, a cell membrane environmental mimic, to study su...		Others
T34556	SC 55858	SC-55858,SC55858
	SC 55858 is a superoxide dismutase mimetic.
T71957	Cupferron
	Cupferron is a superoxide dismutase inhibitor.
T22772	EUK 118		Others
	EUK 118 is a inhibitor of superoxide-mediated reduction of an electron acceptor.		Others
T24817	Otaplimastat	J3.046.690J,SP8203,SP-8203,SP 8203
	SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.
T39205	HKSOX-1
	HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 exhibits excellent selectivity and sensitivity towards superoxide anion radical.
T39763	Rucosopasem manganese	GC4711
	Rucosopasem manganese (GC4711) is a potent, selective superoxide dismutase (SOD) mimetic capable of efficiently converting superoxide to hydrogen peroxide. This compound, specifically designed for research purposes, hold...
T35964	MitoTEMPO hydrate
	MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophili...
T10253	AD 0261		Others
	AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions.		Others
T25118	Avasopasem manganese
	Avasopasem manganese is a drug candidate of superoxide dismutase mimetic.
T7348	Imisopasem manganese	M40403	Others
	Imisopasem manganese (M40403) is a manganese superoxide MnSOD non-peptidyl mimetic.		Others
T22773	EUK 124		Others
	EUK 124 is a inhibitor of superoxide-mediated reduction of an electron acceptor.		Others
T70056	Moschamine
	Moschamine is an inhibitor of mitochondrial superoxide overproduction.
T34472	S1QEL	S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL
	S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation.
T19024	MCLA hydrochloride		Others
	MCLA hydrochloride, a chemiluminescent compound, can be used to quantify aqueous concentrations of superoxide.		Others
T36501	CYPMPO	RR 071
	CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first o...
T71226	Opc 15161
	Opc 15161 is a degradation product of OPC-15160 and superoxide inhibitor.
T40972	1-Oleoyl-2-acetyl-sn-glycerol
	1-Oleoyl-2-acetyl-sn glycerol, a synthetic, cell-permeable diacylglycerol analog, activates calcium-dependent protein kinase C (PKC) and induces superoxide production.
T0260L	Meclofenamate sodium hydrate	INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668
	Meclofenamate sodium is a potent non-steroidal anti-inflammatory agent, which can specifically inhibit chemokine-induced human polymorphonuclear leukocyte function: chemotaxis, degranulation, and superoxide anion free ra...
T35977	6α-hydroxy Cholesterol	6α-hydroxy Cholesterol,6α-OHC
	6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.[1]
T35966	Mn(III)TMPyP
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-...

Compounds

Superoxide dismutase

T78346

Synonym: SOD

Target:

Manganese(salen) chloride

Target: Apoptosis, Phospholipase

Nitrosoglutathione

T19930

Synonym: S-Nitrosoglutathione,SNOG,Glutathione thionitrite,GSNO

Target: RAAS, NO Synthase

Esomeprazole Magnesium

T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Esomeprazole Magnesium trihydrate

T8386

Synonym: (S)-Omeprazole magnesium trihydrate

Target: Reactive Oxygen Species, Mitochondrial Metabolism

MitoSOX Red

T75342

Synonym:

Target: Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Dihydroethidium

T2021

Synonym: PD-MY 003,Hydroethidine

Target: Others

Tempol

T6699

Synonym: TMPN,Tanol,4-Hydroxy-TEMPO

Target: Reactive Oxygen Species, ROS, Autophagy

Tiomolibdate diammonium

T19668

Synonym: Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,Coprexa

Target: Others

Lucigenin

T19023

Synonym: NSC-151912,L-6868

Target: Reactive Oxygen Species

AEOL-10150 pentachloride

T14133

Synonym:

Target: Others

H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate

TP2321L

Synonym: H-PRO-HIS-CYS-LYS-ARG-MET-OH acetate（159147-88-3 free base)

Target: Reactive Oxygen Species, ROS

Synonym: Bis(choline)tetrathiomolybdate

Target: Others

Nitro blue tetrazolium chloride

Synonym: MitoParaquat

Target: Glucokinase, transporter

[Sar1, Ile8]-Angiotensin II acetate

Synonym: 5,5-Dimethyl-1-pyrroline N-oxide

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

7-Acetoxy-4-methylcoumarin

Synonym: SC-55858,SC55858

Synonym: J3.046.690J,SP8203,SP-8203,SP 8203

Rucosopasem manganese

Synonym: S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL

1-Oleoyl-2-acetyl-sn-glycerol

T40972

Synonym:

Target:

Meclofenamate sodium hydrate

T0260L

Synonym: INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668

Target:

6α-hydroxy Cholesterol

T35977

Synonym: 6α-hydroxy Cholesterol,6α-OHC

Cat No.	Product Name	Synonyms	Targets
T9057	Norbergenin		IL Receptor , TNF , Reactive Oxygen Species
	Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi.		IL Receptor , TNF , Reactive Oxygen Species
T3S0218	Thonningianin A		Apoptosis , Others
	1. Thonningianin A has anti-cancer activities.2. Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor.3. Thonningianin A has antioxidant property, involves radical scavenging, anti-superox...		Apoptosis , Others
T2223	Kinetin	6-Furfuryladenine,N6-Furfuryladenine	Others
	Kinetin (N6-Furfuryladenine), a type of cytokinin, has plant growth regulation effects.		Others
TN1916	Matairesinol		ATPase , p38 MAPK , ROS
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.		ATPase , p38 MAPK , ROS
T4931	Dihydroxyfumaric acid hydrate		Others , Endogenous Metabolite
	Dihydroxyfumaric acid is a known generator of superoxide anions and by hydroxyl free radicals. Dihydroxyfumarate exposure can cause insulin inhibitory effects. It can spontaneously convert to hydroxypyruvate or to oxalog...		Others , Endogenous Metabolite
TJS1382	Taraxerone		Dehydrogenase
	Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration with the concentration dep...		Dehydrogenase
TN6647	4-O-Cinnamoylquinic acid		Prostaglandin Receptor
	4-O-Cinnamoylquinic acid is a small molecule compound extracted from the dried fruits of Casearia grewiifolia, which has an inhibitory effect on prostaglandins and inhibits the production of superoxide anions in human ne...		Prostaglandin Receptor
T16527	Phytic acid dodecasodium salt hydrate	myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate	Others , Xanthine Oxidase , Endogenous Metabolite
	Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium salt hydrate inhibits th...		Others , Xanthine Oxidase , Endogenous Metabolite
TN2286	Tsugaric acid A		NO Synthase
	Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates t...		NO Synthase
T6S1440	Loganic acid	Loganate	Others
	1. Loganic acid (Loganate) and geniposide exhibit both sides effect on superoxide generation.		Others
T5S1897	Linderalactone		Apoptosis , Others , JAK
	1. Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.		Apoptosis , Others , JAK
TN3469	Aucuparin	2,6-dimethoxy-4-phenylphenol	NADPH-oxidase
	Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging act...		NADPH-oxidase
T5S2254	Swertianolin	Bellidifolin-8-O-Glucoside	Others , HBV , Antibacterial , AChE
	1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. 2. Swertianolin...		Others , HBV , Antibacterial , AChE
TJS0315	4-Methyldaphnetin	7,8-Dihydroxy-4-methylcoumarin,DHMC	Apoptosis , Lipoxygenase
	4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydr...		Apoptosis , Lipoxygenase
TN4614	N-Methylflindersine	2,2,6-trimethylpyrano[3,2-c]quinolin-5-one,2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one	Others
	N-Methylflindersine (2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one) shows strong toxicity towards brine shrimp larvae, with an LD(50) value of 1.39 microg/ml. It also exhibits potent inhibition against N -formylmethi...		Others
T5543	TriacetonaMine	Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others
	TriacetonaMine (Vincubine) protects the activitis of superoxide dismutase(SOD) and creatine phos-phate kinase (CPK); it also inhibits CaCl2 induced agglomeration of thromocyte. Triacetonamine can improve the constructile...		Others
T5S0281	Tubuloside A		NOS
	Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflammatory effects.Tubuloside A shows stronge...		NOS
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T3388	Calycosin-7-O-β-D-glucoside	calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP , Reactive Oxygen Species
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycos...		MMP , Reactive Oxygen Species
T8280	Deacetylasperulosidic Acid	Desacetyl asperulosidic acid	IL Receptor , Interleukin
	Deacetylasperulosidic Acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage i...		IL Receptor , Interleukin
TN6931	Anemarrhenasaponin Ia	(2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5R,6R)-4,5-dihydroxy-2-{[(1R,3R,4R,7S,9S,12S,13S,16S,18R)-3-hydroxy-6-methoxy-7,9,13-trimethyl-6-(3-methylbutyl)-5-oxapentacyclo[10.8.0.02,?.0?,?.013,1?]icosan-16-yl]oxy}-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxan	Others
	Anemarrhenasaponin Ia ((2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5R,6R)-4,5-dihydroxy-2-{[(1R,3R,4R,7S,9S,12S,13S,16S,18R)-3-hydroxy-6-methoxy-7,9,13-trimethyl-6-(3-methylbutyl)-5-oxapentacyclo[10.8.0.02,?.0?,?.013,1?]icosan-16-yl]...		Others
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
TN4214	Hispanone
	Hispanone possesses anti-inflammatory activity, it shows inhibition of superoxide anion generation and elastase release.
TN2134	Raddeanoside 20		Others
	Raddeanoside 20 can slightly suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) in a concentration dependent manner.		Others
TN2888	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid		Others
	3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.		Others
TN5156	Totaradiol		NADPH-oxidase
	Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line.		NADPH-oxidase
TN5105	Taxagifine		Others
	Taxagifine shows cytotoxic activity toward HepG2 cells; it can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.		Others
T79946	Isorabaichromone		Reactive Oxygen Species
	Isorabaichromone exhibits potent antioxidative properties, including DPPH radical and superoxide anion scavenging activities [1].		Reactive Oxygen Species
TN4045	Evofolin C		Antifection
	Evofolin C and its acetate show strong antifungal and antibacterial activity. Evofolin C exhibits potent inhibition against N-formylmethionylleucylphenylalanine-induced superoxide production with IC(50) values less than ...		Antifection
T75619	Aristololactam IIIa
	Aristololactam IIIa demonstrates substantial inhibition of superoxide anion generation and elastase release, exhibiting IC50 values of 0.12 and 0.20 μg/mL, respectively [1].
TN1503	Cistanoside F		NADPH-oxidase
	Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide ani...		NADPH-oxidase
TN2973	3'-O-Methylmurraol
	3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/...
TN3069	4beta-Carboxy-19-nortotarol		NADPH-oxidase
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not genera...		NADPH-oxidase
TN5104	Taxacin		Others
	Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM). Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) a...		Others
TN1958	Mulberroside F		Tyrosinase
	Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, sug...		Tyrosinase
T83000	Antitumor agent-89
	Antitumor agent-89 (Compd OTS-5), a naturally occurring compound, exhibits weak inhibitory activity against fMLP-induced superoxide generation [1].
T82724	Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside
	Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside, a potent anthraquinone glucoside derived from Rheum undulatum L., exhibits significant DPPH radical and superoxide anion (?O2-) scavenging activity [1].
TN3744	Cyclomorusin		NOS , AChR
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophi...		NOS , AChR
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3....
TN4437	Licorisoflavan A		MMP , IL Receptor , NF-κB , DNA/RNA Synthesis
	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediate...		MMP , IL Receptor , NF-κB , DNA/RNA Synthesis
TN2243	Sugiol	10-Deoxoxanthoperol	IL Receptor , TNF , ROS
	Sugiol (10-Deoxoxanthoperol) has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals. Sugiol's efficacy in inhibiting the ...		IL Receptor , TNF , ROS
T36051	Lipoxin A4	LXA4
	Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide g...
TN2408	Evofolin B		Cannabinoid Receptor
	Evofolin B is a natural compound isolated from the stem bark of Zanthoxylum ailanthoides. Evofolin B has an inhibitory effect on the superoxide anion produced by human neutrophils in response to formyl-L-methionine-L-leu...		Cannabinoid Receptor
T38262	Sphingosine (d14:1)
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fu...
TN3706	Coronarin A
	Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the gr...

Natural Products

norbergenin

T9057

Synonym:

Target: IL Receptor, TNF, Reactive Oxygen Species

Thonningianin A

T3S0218

Synonym:

Target: Apoptosis, Others

Kinetin

T2223

Synonym: 6-Furfuryladenine,N6-Furfuryladenine

Target: ATPase, p38 MAPK, ROS

Dihydroxyfumaric acid hydrate

T4931

Synonym:

Target: Others, Endogenous Metabolite

Taraxerone

TJS1382

Synonym:

Target: Dehydrogenase

4-O-Cinnamoylquinic acid

TN6647

Synonym:

Target: Prostaglandin Receptor

Phytic acid dodecasodium salt hydrate

T16527

Synonym: myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate

Target: Others, Xanthine Oxidase, Endogenous Metabolite

Target: Apoptosis, Others, JAK

Aucuparin

TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

Swertianolin

T5S2254

Synonym: Bellidifolin-8-O-Glucoside

Target: Others, HBV, Antibacterial, AChE

4-Methyldaphnetin

TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,DHMC

Target: Apoptosis, Lipoxygenase

N-Methylflindersine

TN4614

Synonym: 2,2,6-trimethylpyrano[3,2-c]quinolin-5-one,2,2,6-Trimethyl-2H,5H-pyrano[3,2-c]quinolin-5-one

Target: Others

TriacetonaMine

T5543

Synonym: Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Calycosin-7-O-β-D-glucoside

T3388

Synonym: calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Deacetylasperulosidic Acid

T8280

Synonym: Desacetyl asperulosidic acid

Target: IL Receptor, Interleukin

Anemarrhenasaponin Ia

TN6931

Synonym: (2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5R,6R)-4,5-dihydroxy-2-{[(1R,3R,4R,7S,9S,12S,13S,16S,18R)-3-hydroxy-6-methoxy-7,9,13-trimethyl-6-(3-methylbutyl)-5-oxapentacyclo[10.8.0.02,?.0?,?.013,1?]icosan-16-yl]oxy}-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxan

Target: Others

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid

Target: NADPH-oxidase

Target: Reactive Oxygen Species

Target: NADPH-oxidase

4beta-Carboxy-19-nortotarol

TN3069

Synonym:

Target: NADPH-oxidase

Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside

Target: MMP, IL Receptor, NF-κB, DNA/RNA Synthesis

Sugiol

TN2243

Synonym: 10-Deoxoxanthoperol

Target: IL Receptor, TNF, ROS

Target: Cannabinoid Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00104	SOD2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms to...
TMPJ-00105	SOD2 Protein, Human, Recombinant (His)	Human	Human Cells
	Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic super...
TMPY-02044	SOD2 Protein, Human, Recombinant	Human	E. coli
	Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is locat...
TMPH-00052	Superoxide dismutase [Fe] Protein, Anabaena sp., Recombinant (His & KSI)	Anabaena sp.	E. coli
	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
TMPY-01585	SOD1 Protein, Human, Recombinant (His)	Human	E. coli
	SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmi...
TMPH-01317	SOD3 Protein, Human, Recombinant (His)	Human	E. coli
	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
TMPH-01318	SOD3 Protein, Human, Recombinant	Human	E. coli
	Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
TMPH-01746	NOX4 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor...
TMPH-01022	C5AR1 Protein-VLP, Human, Recombinant (His)	Human	HEK293
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transm...
TMPH-02658	FPR1 Protein, Mouse, Recombinant (GST & His & Myc)	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release...
TMPH-01745	NOX4 Protein, Human, Recombinant (Cell-Free, His)	Human	in vitro E. coli expression system
	Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor...
TMPH-01023	C5AR1 Protein, Human, Recombinant (Cell-Free, His)	Human	in vitro E. coli expression system
	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transm...
TMPH-01346	FPR1 Protein, Human, Recombinant (GST & His & Myc)	Human	E. coli
	High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release...
TMPH-01744	NOX1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-d...
TMPJ-00582	PRG3 Protein, Human, Recombinant (His)	Human	Human Cells
	Proteoglycan 3, also known as Eosinophil major basic protein homolog, Prepro-major basic protein homolog, PRG3 and MBPH, contains one C-type lectin domain. Proteoglycans are a major component of the animal extracellular ...
TMPY-02686	PON3 Protein, Human, Recombinant (S50N, His)	Human	Baculovirus-Insect Cells
	PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expressi...
TMPH-03751	CYBB Protein, Human, Recombinant (His)	Human	E. coli
	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membr...
TMPJ-00848	NCF1 Protein, Human, Recombinant (His)	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a mem...
TMPY-03660	P67phox Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPH-01070	CD177 Protein, Human, Recombinant (GST & His)	Human	E. coli
	In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integri...
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical produ...
TMPY-03619	P67phox Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPY-02464	Catalase/CAT Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Catalase is a ubiquitously expressed enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a tetramer of four polypeptides chains containing four porphyrin heme groups that allow the enz...
TMPY-04122	ATOX1 Protein, Human, Recombinant (His)	Human	E. coli
	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the t...
TMPY-03038	CD157 Protein, Rat, Recombinant (His)	Rat	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00968	CD157 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-03037	CD157 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01178	CD157 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05600	CD66B Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	CEACAM8, also known as CD66b or NCA-95, is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic antigen family. There are four members in this family: CD66a, CD66b, CD66c, and CD66d...
TMPY-01638	CD66B Protein, Human, Recombinant (His)	Human	HEK293
	CEACAM8, also known as CD66b or NCA-95, is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic antigen family. There are four members in this family: CD66a, CD66b, CD66c, and CD66d...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...