ssdna

6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.

Deoxyribonucleic acid sodium salt from salmon testes (ssstDNA) is utilized in creating anti-adhesion layers (AAL) for the passivation of gold plasma sensor surfaces.

Phenazine methylsulfate is anti-bacterial agents.

TFE-IDAtp1-LinA is an efficient amphiphilic carrier that contains a trifluoroethyl imino diacetic acid analogue with Stp. It forms nanoparticles with Cas9 RNP ssDNA, facilitating the knockout of enhanced green fluorescent protein, with an ED50 of 0.38 nM Cas9 sgRNA ribonucleoprotein (RNP).

RAD51-IN-9 (Compound 3a) is an inhibitor of RAD51, specifically blocking its binding to ssDNA, with an IC50 of 17.85 μM. The compound has an LD50 of 40.21 μM in HEK293 cells and can sensitize cells to mitomycin C.

SARS-CoV-2 nsp13-IN-4 (C4 (d)) is a potent and selective small-molecule inhibitor of nsp13 helicase, inhibiting the ssDNA+ ATPase activity of nsp13 with an IC50 of 57 μM, and providing a broad-spectrum antiviral effect.

SARS-CoV-2 nsp13-IN-6 (compound C5) is a potent inhibitor of the SARS-CoV-2 non-structural protein 13 (nsp13), targeting ssDNA+ATPase (IC50: 27 μM) and ssDNA-ATPase (IC50: 33 μM). nsp13-IN-6 can be utilized in anti-COVID-19 research.

SARS-CoV-2 nsp13-IN-2 (Compound C2) is a small molecule inhibitor targeting the SARS-CoV-2 non-structural protein 13 (nsp13), specifically acting on the nsp13 ssDNA+ATPase with an IC50 of 42 μM.

SARS-CoV-2 nsp13-IN-3 (Compound C3) is a small molecule inhibitor of SARS-CoV-2 non-structural protein 13 (nsp13), targeting nsp13 ssDNA+ATPase with an IC50 of 32 μM.

SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13), selectively inhibiting nsp13 ssDNA+ATPase with an IC50 of 6 μM, but not ssDNA-ATPase, and can be used to study COVID-19.

SARS-CoV-2 nsp13-IN-5 is a potent inhibitor of SARS-CoV-2 nsp13, effective on ssDNA+ATPase (IC50: 50 μM) and ssDNA-ATPase (IC50: 55 μM). It is applicable in anti-COVID-19 studies.

Nuclease S1, a specific endonuclease, degrades single-stranded DNA (ssDNA) and RNA, and can remove protruding single-strand ends from double-stranded DNA [1] [2].