T8630 |
Baclofen hydrochloride
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4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride |
GABA Receptor
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Baclofen hydrochloride 是一种 GAMMA-AMINOBUTYRIC ACID 衍生物,是一种特异性 GABA-B 受体激动剂。它用于治疗肌肉痉挛,尤其是由于脊髓损伤引起的肌肉痉挛。其治疗效果来自于脊髓和脊髓上部位的作... |
T6355 |
(R)-baclofen
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STX209,(R)-巴氯芬,Arbaclofen |
GABA Receptor
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(R)-Baclofen 是一种选择性GABAB 受体激动剂。 |
T11986L |
Mebeverine acid hydrochloride
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Mebeverine acid hydrochloride 是一种有效的、可口服的、可直接作用于胃肠道平滑肌解除痉挛症状的化合物。 |
T8452 |
Dantrolene
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Others
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Dantrolene 是一种肌肉松弛剂,是人红细胞谷胱甘肽还原酶的非竞争性抑制剂,其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经... |
T72023 |
JB002
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Myosin
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JB002 是一种肌球蛋白 II 抑制剂,IC50值 ≤10 μM。JB002 可用于肌肉痉挛、慢性肌肉骨骼疼痛、肥厚型心肌病的研究。 |
T0077 |
Dantrolene sodium
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丹曲林钠,Lapatinib ditosylate monohydrate,Dantrolene sodium salt |
Others
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Calcium Channel
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Dantrolene sodium salt 是一种骨骼肌松弛药,是一种钙通道蛋白抑制剂,可抑制钙离子从肌浆释放。 |
T5295 |
1-Hydroxyoctadecane
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Octadecanol,1-Octadecanol,Stearyl alcohol,硬脂醇 |
Endogenous Metabolite
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Others
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1-Octadecanol 是内源性代谢产物的一种。 |
T1308 |
Orphenadrine hydrochloride
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Mephenamin,盐酸邻甲苯海拉明,Mebedrol |
Sodium Channel
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NMDAR
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Norepinephrine
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iGluR
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Histamine Receptor
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Orphenadrine hydrochloride 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。 |
T1065 |
Baclofen
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Lioresal,巴氯芬 |
GABA Receptor
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Baclofen 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物,是可口服的选择性代谢型 GABA-B 受体激动剂,具有高血脑屏障渗透率,用于治疗因脊髓损伤和多发性硬化引起的痉挛。 |
T6618 |
Orphenadrine Citrate
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枸酸芬那君,奥芬那君,Flexoject,Flexon,Banflex |
iGluR
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AChR
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Orphenadrine Citrate 是NMDA 受体拮抗剂,Ki 为6.0μM,还是HERG 钾离子通道阻断剂。它是一种骨骼肌松弛剂,它作用于中枢神经系统以产生肌肉松弛作用。 |
T1092 |
Zolmitriptan
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311C90,BW-311C90,佐米曲普坦 |
5-HT Receptor
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Zolmitriptan 是一种5-HT1B/1D 受体部分激动剂,可用于偏头痛的研究,对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。 |
T67952 |
JB062
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Myosin
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JB062 是一种非肌肉肌球蛋白 (nonmusclemyosin) 抑制剂,对骨骼肌肌球蛋白、心肌肌球蛋白和平滑肌肌球蛋白 II 的IC50值分别为分别为 1.6、5.4 和 >100 μM。JB062 对人类癌细胞具有细胞毒性,但对正常... |
T28657 |
SAD-448
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SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve C... |
T21077 |
Tolperisone free base
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Menopatol,Atmosgen free base,Mideton,Mydocalm,Mydeton,Besnoline free base |
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Tolperisone free base, a centrally acting muscle relaxant, has been used for the symptomatic treatment of spasticity and... |
T29117 |
VSN-16
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VSN16R,VSN 16R,VSN-16R |
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VSN-16, a cannabinoid receptor agonist, is used potentially for the treatment of spasticity in multiple sclerosis. |
T17306 |
(R)-Baclofen hydrochloride
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Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐 |
GABA Receptor
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Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to... |
T73439 |
MPH-220
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MPH-220 是一种选择性的、具有口服活性的骨骼肌myosin-2抑制剂。MPH-220 可使肌肉放松。MPH-220 是一种抗痉挛剂,可用于痉挛和肌肉僵硬的研究。 |
TMPY-03282 |
FUCA1 Protein, Human, Recombinant (His Tag)
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FUCA1 is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in... |
TMPY-01876 |
HSP60 Protein, Human, Recombinant (His & GST Tag)
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HSPD1, also known as HSP60, is a member of the chaperonin family. HSPD1 may function as a signaling molecule in the inna... |
TMPY-01057 |
SPG21 Protein, Human, Recombinant (GST Tag)
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Spastic paraplegia 21 (SPG21), also known as acid Cluster Protein 33 (ACP33) and Mast syndrome protein, is a member of t... |