serine

L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin.

D-Serine ((R)-Serine), an endogenous amino acid, is a potent co-agonist at the NMDA glutamate receptor.

Elastase from porcine pancreas is a serine protease derived from the porcine pancreas, consisting of 240 amino acid residues. It has the ability to hydrolyze proteins and peptides, can induce emphysema in hamsters, and is commonly used to establish animal models of chronic obstructive pulmonary disease (COPD).

Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively).

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA), with IC50 values of 237 nM for uPA, 1600 nM for tPA, and 1850 nM for Plasmin.

LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).

AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.

AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)

N-Oleoyl-L-Serine (N-Oleoylserine) is an endogenous long-chain fatty acid amide that is a lipid modulator of bone remodeling and stimulates osteoclast apoptosis which can be used to study osteoporosis. N-Oleoyl-L-Serine showed high activity in an osteoblast proliferation assay.N-Oleoyl-L-Serine promotes osteoclast apoptosis by inhibiting Erk1/2 phosphorylation and expression of nuclear κB ligand (RANKL) receptor activator in bone marrow stromal cells and osteoblasts, which attenuates osteoclast populations.

N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a hydrolysis product of enterobactin. It exhibits anti-tumor properties by inhibiting the invasion of mouse colon cancer cell line 26-L5, with an IC50 value of 2.7 μM. Additionally, it shows no significant antibacterial activity against Micrococcus luteus, Escherichia coli, and Candida albicans.

L-Serine-S2-PEG-Formic acid is a linker used in FGT-4, which acts as a TLR7 agonist and is a chimeric molecule that targets folate receptor beta (FR-β).

L-Serine-1-13C is an amino acid.

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)) can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors. It has been utilized in the formation of unilamellar vesicles to study membrane structure curvature and in supported lipid bilayers to examine the impact of various support materials on lipid redistribution between membrane leaflets.

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product obtained through NADPH oxidase activation and Lyso-PS signal transduction. This compound utilizes macrophage G2A function to enhance the receptor/ligand system, thereby resolving neutrophil inflammation.

N-Cbz-DL-serine is a useful organic compound for research related to life sciences. The catalog number is T65211 and the CAS number is 2768-56-1.

DL-Serine Hydrazide Hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66044 and the CAS number is 55819-71-1.

N-Cbz-D-serine Methyl Ester is a useful organic compound for research related to life sciences. The catalog number is T66377 and the CAS number is 93204-36-5.

Glycyl-l-serine is a useful organic compound for research related to life sciences. The catalog number is T66681 and the CAS number is 7361-43-5.

Serine Hydrolase Inhibitor-21 (compound 8), a pyridine-based serine hydrolase inhibitor, exhibits a K i of 429 nM against BuChE, and shows promise for Alzheimer's disease research [1].

N-Arachidonoyl-L-serine (ARA-S), a recently isolated endocannabinoid with a distinct activity profile that diverges from typical endocannabinoids, does not interact with central cannabinoid (CB1), peripheral cannabinoid (CB2) receptors, or vanilloid receptor 1 (VR1). Unlike other compounds, ARA-S (5 mg/kg) counteracts the lowering of blood pressure induced by a 10 mg/kg intravenous bolus of abnormal cannabidiol (Abn-CBD) in anesthetized rat models. Additionally, akin to Abn-CBD, ARA-S induces relaxation in isolated rat mesenteric arteries and abdominal aorta and promotes phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in human umbilical vein endothelial cells (HUVEC). The mechanisms through which ARA-S and Abn-CBD exert their effects on vascular systems show variations and merit deeper investigation.

L-Serine-1-13C (Standard) is a reference standard of L-Serine-1-13C intended for quantitative analysis, quality control, and related biochemical research applications. L-Serine-1-13C is an amino acid.

L-Serine-13C3 (Standard) is a reference standard of L-Serine-13C3 intended for quantitative analysis, quality control, and related biochemical research applications.

L-Serine-phosphoethanolamine is a nucleotide metabolite.

2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A (Compound 33) is a derivative of Cyclosporine. This compound exhibits an IC50 of 0.11 μg/mL in mixed lymphocyte reaction assays.