scg

Expression system: E. coli
Length: 1-876, Full Length
Activity: Not Tested

Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin SCGN is also a novel marker for neuroendocrine differentiation.

Expression system: HEK293 Cells
Length: 1-95, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-93, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-104, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 24-95, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 22-139, Full Length of Mature Protein of Isoform C
Activity: Not Tested

Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. Unlike many other known angiogenic factors, the pro-angiogenic actions of Scg3 are restricted to pathological conditions. Among thousands of quantified endothelial ligands, Scg3 has the highest binding activity ratio to diabetic vs. SG3 Secretogranin 3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 52.14 kDa and the accession number is I7G9U8.

Expression system: E. coli
Length: 328-677, Partial
Activity: Not Tested

Cell adhesion molecules belonging to the Cadm family, and in particular Cadm3 (axonal) and its heterophilic binding partner Cadm4 (Schwann cell), mediate these interactions along the internode.over-expressing Cadm3 on the surface of DRG neuron axons results in an almost complete inability by Schwann cells to form myelin segments. Axons of superior cervical ganglion (SCG) neurons, which do not normally support the formation of myelin segments by Schwann cells, express higher levels of Cadm3 compared to DRG neurons.

Expression system: HEK293 Cells
Length: 20-468, Full Length of Mature Protein
Activity: ELISA

Expression system: E. coli
Length: 23-471, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-179, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 418-617, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-179, Full Length
Activity: Not Tested