recognition

Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimotor gating in rodents.

THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).

Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blockin

IFN-α Receptor Recognition Peptide 1, associated with receptor interactions, is a peptide of IFN-α.

S 18986 is a selective, orally active, brain-penetrant positive allosteric modulator of AMPA-type receptors that enhances cognition in rodents by inducing the release of noradrenaline and acetylcholine in the rat hippocampus, subsequently improving object-recognition memory.

Opipramol (Ensidon) is a compound with antidepressant activity that attenuates cocaine-seeking behavior in a rat model of self-administration.Opipramol is a sigma (σ) receptor agonist with anxiolytic activity and may be used in the study of neurological disorders.

YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a binding affinity with a K_i value of 37 nM.

Terpin hydrate, a cis-form hydrate, is derived from sources such as oil of turpentine, oregano, thyme, and eucalyptus. It is used as an insect repellent and expectorant. Terpin hydrate(cis-Terpin hydrate) is commonly used to loosen mucus and ease congestion in patients presenting with acute or chronic bronchitis, and related pulmonary conditions. It was popular in the United States since the late nineteenth century, but was removed from marketed medications in the 1990s after the U.S. Food and Drug Administration (FDA) stated that "based on the evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients". Elixirs of terpin hydrate are still available with a prescription but must be prepared by a compounding pharmacy.

N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.

Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors.

3-Aminopropyltriethoxysilane (APTES) immobilizes biomolecules on silicon-based materials, such as Si3N4, while acting as a spacer to provide spatial freedom and higher activity for immobilized biomolecules to build analytical platforms for biosensing, recognition and more.

Brexpiprazole HCl (OPC 34712 dihydrochloride) is a new antipsychotic drug.

Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. [1]. Apramycin, From Wikipedia

Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 acetate(1095179-01-3 free base) selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.

1, 8-naphthyridine-2,7-diamine can act as a recognition molecule that acts as a universal base pair reader in electronic tunneling for genome sequencing, producing distinguishable features for each DNA base pair under electrical bias.

4-(N-Succinimidylcarboxy)benzophenone is a photoactive reagent specifically designed for biochemical research. Its molecule contains both succinimide ester groups and benzophenone structures. It can be used to explore the binding sites between proteins and proteins, as well as between proteins and nucleic acids, and to lock the transient interaction complexes through light-controlled cross-linking. It can also assist in the preparation of stable antigen-antibody conjugates, providing reliable materials for biochemical detection, molecular recognition and other experiments.

trans-D-4-Hydroxyproline is a biochemical reagent employed in glycobiology research. Glycobiology explores the structure, synthesis, biology, and evolution of sugars. This field encompasses carbohydrate chemistry, enzyme studies related to glycan formation and degradation, protein-glycan recognition, and the role of glycans within biological systems, with significant links to fundamental research, biomedical sciences, and biotechnology.

Phenylmethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside is a biochemical reagent used in glycobiology research. Glycobiology focuses on the structure, synthesis, biology, and evolution of sugars, involving carbohydrate chemistry, glycan formation, and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. This field is intricately linked to fundamental research, biomedicine, and biotechnology.

SL agonist 1, a Strigolactone (SL) agonist, is effective in promoting Arabidopsis seed germination through its recognition by the SL receptors OmKAI2d3 and OmKAI2d4.

3,4,6-Tri-O-benzyl-D-galactal is a biochemical reagent used in glycobiology research. Glycobiology explores the structure, synthesis, biology, and evolution of sugars. It encompasses carbohydrate chemistry, the enzymology of glycan formation and degradation, glycoprotein-glycan recognition, and the role of glycans in biological systems. This field is closely linked with basic research, biomedicine, and biotechnology.

5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.

Z944 is a T-type calcium channel antagonist with potential applications in pain management. In both epileptic and non-epileptic rats, Z944 disrupts prepulse inhibition. Additionally, it corrects cross-modal sensory and visual recognition memory deficits in Strasbourg genetic absence epilepsy rats. In a neuropathic pain rat model, Z944 restores cortical synchrony and thalamocortical connectivity. In the amygdala kindling model, it delays seizure progression.

α-L-fucopyranose, an endogenous metabolite and six-carbon deoxyhexose, is present at the terminal or anterior position of many cell surface oligosaccharide ligands, mediates cell recognition and adhesion signaling pathways, and is a potentially critical molecule in pathological processes, including tumors.

VU6024578 (BI02982816) is an orally bioavailable and selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGluR1. It demonstrates activation with EC50 values of 54 nM for human mGluR1 and 46 nM for rat mGluR1. VU6024578 shows antipsychotic activity in rat models of amphetamine-induced hyperactivity and MK-801-induced novel object recognition (NOR). Additionally, it possesses blood-brain barrier permeability.