quorum

N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer and a natural, active ligand of LuxR.

Quorum Sensing-IN-3 (QS-IN-1) is a compound with inhibitory effects on bacterial community sensing, which inhibits the exchange of information between bacteria and inhibits biofilm formation.

Quorum sensing-IN-8 (compound 5e) exhibits antibiofilm activity and can be used in research on antibiotic resistance.

Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding to the PqsR protein. It suppresses the expression of quorum sensing system-related genes lasB, rhlA, and pqsA, thereby preventing the production of virulence factors elastase, pyocyanin, and rhamnolipid. Quorum sensing-IN-9 disrupts the motility of P. aeruginosa, inhibits biofilm formation, and reduces the bacterium's virulence and pathogenicity. Additionally, it exhibits anti-infective activity in the Galleria mellonella larval model.

Quorum sensing-IN-10 (10p) is an antimicrobial adjuvant that significantly inhibits the virulence, biofilm formation, and motility of Pseudomonas aeruginosa, while exhibiting low toxicity. It is applicable for research related to drug-resistant Pseudomonas aeruginosa infections.

Quorum sensing-IN-5 is an RpfF-targeted quorum-sensing inhibitor. It suppresses Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 9.91 μg/mL and 7.04 μg/mL, respectively. Quorum sensing-IN-5 exhibits antimicrobial activity.

Quorum Sensing-IN-1 [QSI-1] is a small-molecule inhibitor targeting quorum sensing.

Quorum Sensing-IN-2 (compound 23e) is a quorum sensing inhibitor that reduces bacterial pathogenicity without affecting growth, exhibits minimal hemolytic activity, effectively inhibits bacterial infections, and shows a synergistic effect when combined with Ciprofloxacin in a P. aeruginosa PAO1-infected bacteremia model [1].

Quorum sensing-IN-6 (compound 27) is a quorum sensing (QS) inhibitor with IC50 values of 8 nM and 106 nM against E.coli and Pyocyanin, respectively.

Quorum sensing-IN-7 (compound HSL 4) is an effective quorum sensing (QS) inhibitor. It interacts with the binding sites Leu 72 and Gln 95 of CviR. As an antimicrobial agent, Quorum sensing-IN-7 effectively inhibits the production of homoserine lactones (HSLs) and biofilms in C. violaceum at concentrations ranging from 0.25-1 mg/mL.

Quorum sensing-IN-4 (compound 2) is a quorum sensing inhibitor isolated from the Streptomyces sp. OUCMDZ-5511 found in Thai mangroves.

L-Homoserine lactone hydrochloride constitutes the core structural unit of N-acetylhomoserine lactone (AHL), a bacterial quorum sensing signal molecule.

Methyl anthranilate is a natural product. Methyl anthranilate is a novel quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria

LED209, a specific inhibitor of quorum sensor QseC of GNB, can generate a multifunctional agent PAMAM-LED209.

QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species( SmcR with an EC50 of 208.9 nM).

Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and HIV-1 integrase activity, yet it does not impact Gram-negative bacteria.

Curvularin ((S)-Curvularin) is a quorum-sensing antagonist of Pseudomonas aeruginosa RhlR extractable from Curvularia lunata, a mycotoxin with anti-inflammatory activity, inhibition of cytokine-induced NO synthase, and inhibition of lipopolysaccharide-induced inflammation in antimyelocytes. study inflammation.

N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule that impacts biofilm formation in bioreactors through acyl homoserine lactone (AHL) mediated microbial communication.

LasR-IN-5 (compound 3C) acts as an antagonist of LasR with an IC50 of 1.37 μM, exhibiting a 77% inhibition in the formation of Pseudomonas biofilms. Moreover, LasR-IN-5 also demonstrates inhibitory activity against quorum sensing (QS) and is applicable in infection research.

Antibacterialsynergist 3 is a dual-function biofilm inhibitor with an IC50 of 0.40 μM for PAO1 and 1.45 μM for PA14. It reduces virulence in Pseudomonas aeruginosa PAO1 by inhibiting the quorum sensing (QS) system and inducing iron deficiency. Additionally, Antibacterialsynergist 3 enhances the efficacy of Tobramycin and Ciprofloxacin in a mouse wound infection model. This compound is useful for research on Pseudomonas aeruginosa infections.

Antibiofilm agent-4 is a LasR inhibitor, demonstrating optimal antibiofilm and anti-QS (quorum sensing) properties.

Antibiofilm agent-6 (Compound 26c) is a quorum sensing inhibitor with antibiofilm properties, effectively reducing the fluorescence intensity of PAO1-lasB-gfp and PAO1-pqsA-gfp in a concentration-dependent manner. It suppresses the production of pyocyanin and rhamnolipids and enhances the efficacy of ciprofloxacin in eradicating viable bacteria in a Pseudomonas aeruginosa (P. aeruginosa PAO1) infected mouse model.

Antibacterialagent 210 (compound A9) is an amide derivative that acts as a quorum sensing inhibitor (QSI) for Pseudomonas aeruginosa. It functions by binding particularly to PqsR, and also to LasR, thereby inhibiting the quorum sensing system.

Antibiofilm agent-17 is a dual-action biofilm inhibitor (IC50 = 0.33 μM) targeting Pseudomonas aeruginosa. It inhibits biofilm growth by reducing virulence production regulated by the quorum sensing system and decreasing iron acquisition capability. In a mouse wound infection model, Antibiofilm agent-17 shows synergistic antibacterial activity. This compound is useful for research on combating Pseudomonas aeruginosa infections.