quinazoline

7-Bromoquinazoline-2,4(1H,3H)-Dione (7-Bromo-2,4(1H,3H)-quinazolinedione) is a marine derived natural products found in Pyura sacciformis.

Terazosin hydrochloride (Hytrin) , a selective alpha1-antagonist, can treat the benign prostatic hyperplasia (BPH). It also can lower blood pressure, so it is a drug of choice for patients with prostate enlargement and hypertension. It works on the smooth muscle of the bladder and the blood vessel walls by blocking the function of adrenaline.

UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.

UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.

hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.

Terazosin hydrochloride dihydrate (Heitrin dihydrate) is a selective α1-adrenoceptor antagonist, used for treatment of symptoms of an enlarged prostate (BPH).

Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803.

Quinazoline ,with CAS No. 253-82-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Quinazoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.

Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]

MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.

12-oxo-N-[1-(propan-2-yl)piperidin-4-yl]-6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide available as a molecular structural unit, it is used in the synthesis of various compounds.

Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.

Tryptanthrin is a natural DNA gyrase inhibitor.

3-Carboxymethyl-quinazoline-2,4-dione ,with CAS No. 78754-94-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Carboxymethyl-quinazoline-2,4-dione provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine is a useful organic compound for research related to life sciences. The catalog number is T66391 and the CAS number is 314771-76-1.

4-CHLORO-QUINAZOLINE, with CAS No. 5190-68-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-CHLORO-QUINAZOLINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-(2-Hydroxyethyl)-2,4-(1H,3H)-quinazoline-dione is a specialized biomedical research reagent extensively utilized in chemical constituent synthesis, medicinal chemistry optimization, and experimental biological pathway research,the unique molecular structure supports structure–activity relationship studies, molecular interaction analysis, and the development of bioactive compounds with potential pharmacological and translational research applications.

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5

2,4-Dihydroxyl-6-fluoroquinazoline ,with CAS No. 88145-90-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,4-Dihydroxyl-6-fluoroquinazoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Bromo-4-hydroxyquinazoline, with CAS No. 32084-59-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Bromo-4-hydroxyquinazoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-Fluoro-4-hydroxyquinazoline ,with CAS No. 436-72-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-Fluoro-4-hydroxyquinazoline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.

7-Chloroquinazoline-2,4(1H,3H)-dione ,with CAS No. 13165-35-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-Chloroquinazoline-2,4(1H,3H)-dione provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.