purines

Olomoucine is an ATP-competitive inhibitor of Cdk2 cyclin A, Cdc2 CyclinB, CDK2 CyclinE, CDK5 p35, and ERK1 p44 MAP kinase with IC50s of 7, 7, 7, 3, and 25 µM, respectively. It regulates the cell cycle and exhibits anti-melanin tumor activities.

Zeatin is a cytokinin derived from adenine. Zeatin was discovered in immature corn kernels from the genus Zea. It promotes growth of lateral buds and when sprayed on meristems stimulates cell division to produce bushier plants.

trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.

Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.

Purine (7H-Imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines from food (or from tissue turnover) are metabolised by several enzymes, including xanthine oxidase, into uric acid. High levels of uric acid can predispose to gout when the acid crystalises in joints; this phenomenon only happens in humans and some animal species (e.g. dogs) that lack an intrinsic uricase enzyme that can further degrade uric acid.

Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1 2 (hSHMT1 2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causing detectable levels of DNA strand breaks. Lometrexol disodium exhibits anticancer effects by inhibiting the de novo synthesis of purines, causing abnormal cell proliferation, apoptosis and cell cycle arrest.

Heterocyclic compound –purines, intermediate and building block; Used for modified nucleosides and nucleic acids

Heterocyclic Compounds –Purines; Intermediates and Building Blocks - Nucleoside bases

Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Electrophiles

Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Nucleophiles

1,9-Dihydro-9-methyl-6H-purin-6-one belongs to Heterocyclic Compounds - Purines.

Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Nucleoside bases; Multi-functional; Scaffolds and Templates

1,7-Dibenzyl-3-methylxanthine belongs to Heterocyclic Compounds - Purines.

7-benzyl-3-methylxanthine belongs to Heterocyclic Compounds - Purines.

1H-Imidazo[4,5-d]pyridazin-7-amine belongs to Heterocyclic Compounds - Purines; Intermediates and Building Blocks - Nucleoside bases.