protein disulfide isomerase (pdi)

PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.

PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.

ML359 is a protein disulfide isomerase inhibitor.

(E Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E Z)-E64FC26 can be used for myeloma research.

AS15 is a novel covalent nanomolar inhibitor of protein disulfide isomerase (PDI).

BAP2 is a novel inhibitor of protein disulfide isomerase (PDI).

KSC-34 is a covalent modifier of protein disulfide isomerase A1 (PDIA1).KSC-34 is a selective inhibitor targeting the a-site of PDIA1.It inhibits PDIA1 reductase activity in a time-dependent manner and is used to study diseases caused by abnormalities in amyloid.128-63-63-5

16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices. 1.Hoffstrom, B.G., Kaplan, A., Letso, R., et al.Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsNat. Chem. Biol.6(12)900-906(2010)

PDI-IN-P1 is an inhibitor of protein disulfide isomerase.

Bacitracin F is a major Bacitracin analog -- a peptide antibiotic used as an inhibitor of protein disulfide isomerase (PDI).

3-Methyltoxoflavin (3-methyl toxoflavin) is an effective inhibitor of protein disulfide isomerase (PDI) and its IC50 value is 170 nM.

Juniferdin, a Protein disulfide isomerase (PDI) inhibitor with an IC50 of 3.5 μM, is designed to prevent HIV transmission. It exhibits cytotoxic properties and inhibits platelet aggregation [1].

E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer.