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Results for "

protein–protein interaction (ppi)

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    34
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    2
    TargetMol | Compound_Libraries
  • Dye Reagents
    1
    TargetMol | Dye_Reagents
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    TargetMol | PROTAC
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ZW4864 free base
T96422632259-92-6In house
ZW4864 (free base) is an orally active and selective β-catenin B-Cell lymphoma 9 protein-protein interaction (β-catenin BCL9 PPI) inhibitor, with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM [1]. ZW4864 (free base) also demonstrates good pharmacokinetic properties.
  • Inquiry Price
6-8 weeks
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M2I-1
M2I 1
T4647312271-03-7
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cd
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TargetMol | Inhibitor Sale
DDO-5936
T92022355377-13-6
DDO-5936 is a potent and specific inhibitor of the protein-protein interaction (PPI) between HSP90 and Cdc37.
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TargetMol | Inhibitor Sale
BRCA1-IN-2
T106011622262-55-8
BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins.
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8-10 weeks
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DRI-C21045
T110962101765-81-3
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L synergistic stimulator protein-pro
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IPR-803
T11666892243-35-5
IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.
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6-8 weeks
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S1g-10
S1g10
T2013963032432-71-3
S1g-10 is an Hsp70 Bim inhibitor that exhibits significant antitumor activity, particularly in chronic myeloid leukemia (CML) cells. It inhibits the protein-protein interaction between Hsp70 and Bim, blocking cancer cell survival signals and inducing apoptosis. S1g-10 is an optimized derivative of S1g-2, with a 10-fold increase in anticancer potency.
    Inquiry
    MDK-3298
    MDK3298, Mcl-1 Inhibitor-5, Mcl-1 Inhibitor5, Mcl-1 Inhibitor 5
    T279962012563-29-8
    MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    ISIR-005
    ISIR 005
    T32200
    ISIR-005 is a natural stabilizer of the 14-3-3/Gab2 protein-protein interaction (PPI) interface.
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    Size
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    RAS inhibitor Abd-7
    T366412351843-48-4
    RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].
    • Inquiry Price
    6-8 weeks
    Size
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    β-catenin-IN-37
    T392001783856-40-5
    β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
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    PCSK9-IN-2
    PCSK9-IN-2
    T395282099167-44-7
    PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
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    ZW4864
    T402562632259-93-7
    ZW4864 is a selective inhibitor of the β-catenin B-Cell Lymphoma 9 protein (β-catenin BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.
      7-10 days
      Inquiry
      TAS1553
      T602172166023-31-8
      TAS1553 is a highly effective, orally bioavailable protein-protein interaction (PPI) inhibitor with an IC50 value of 0.0396 μM. It effectively hinders DNA replication and diminishes the intracellular dATP pool. Moreover, TAS1553 induces apoptosis, making it a valuable compound in cancer research [1].
      • Inquiry Price
      7-10 days
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      (R)-STU104
      T606572767124-77-4
      (R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1 MKK3 p38 MnK1 MK2 elF4E signalling pathway by binding to MKK3 and disrupting TAK1 phosphorylation of MKK3. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.
      • Inquiry Price
      6-8 weeks
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      RAD51-IN-8
      T61469
      RAD51-IN-8, a new RAD51 binder, is a RAD51-BRCA2 inhibitor that disrupts the RAD51 BRCA2 protein-protein interaction in the micromolar range. This protein-protein interaction (PPI) inhibitor also demonstrates inhibitory activity for H4A4 with an EC50 value of 19 μM [1].
      • Inquiry Price
      10-14 weeks
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      Keap1-Nrf2-IN-5
      T632942696272-70-3
      Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).
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      10-14 weeks
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      rel-MDM2/4-p53-IN-3
      T63438
      rel-MDM2 4-p53-IN-3 is an MDM2 4-p53 protein-protein interaction (PPI) inhibitor that acts on MDM2-p53 and MDM4-p53 with IC50 values of 18.5 nM and 14.8 nM, respectively. rel-MDM2 4-p53-IN-3 can be used to study cancers, such as colon cancer.
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      10-14 weeks
      Size
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      MI-773
      T639741303607-07-9
      MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.
        7-10 days
        Inquiry
        NXPZ-2
        T642142254492-08-3
        NXPZ-2 is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and function, and improves pathological alterations in the brain of Alzheimer's disease (AD) mice. NXPZ-2 has potential for studies of Keap1-Nrf2 PPI inhibitors and AD-related disorders.
        • Inquiry Price
        6-8 weeks
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        UU-T01
        T707211417162-83-4
        UU-T01 is a selective inhibitor of the β-Catenin T-cell factor 4 (β-catenin Tcf) protein-protein interaction (PPI), exhibiting a Ki value of 3.14 µM, and directly binds to β-catenin with a KD value of 0.531 µM.
        • Inquiry Price
        8-10 weeks
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        Keap1-Nrf2-IN-13
        T727062456294-92-9
        Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with an IC50 value of 0.15 μM, indicating high efficacy. It binds strongly to Keap1 by forming hydrogen bonds with critical polar residues (Asn414, Arg415, Arg483, Gln530), showcasing specificity. This compound has implications for research into diseases associated with oxidative stress and inflammation, such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and cancers, due to its mechanism of action.
        • Inquiry Price
        6-8 weeks
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        Keap1-Nrf2-IN-6
        T72760
        Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 proteinprotein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM and a dissociation constant (Kd) of 68 nM.
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        8-10 weeks
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        PRMT5:MEP50 PPI
        T72785
        PRMT5:MEP50 PPI, a pioneering inhibitor of the PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI), demonstrates anti-tumor and anti-proliferative effects in lung and prostate cancer cells.
        • Inquiry Price
        6-8 weeks
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