protac linker 5

NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that can be used for the synthesis of PROTAC molecules.

MS 39 is a potent Proteolysis Targeting Chimera (PROTAC) designed to degrade the Epidermal Growth Factor Receptor (EGFR). The molecule is composed of three structural motifs: an EGFR target ligand (red part), a VHL E3 ligase ligand (S,R,S)-AHPC (blue part), and an undecanedioic acid linker (black part). By facilitating the formation of a ternary complex between EGFR and the VHL E3 ubiquitin ligase, MS 39 triggers the polyubiquitination and subsequent proteasomal degradation of the receptor. MS 39 effectively reduces EGFR protein levels and inhibits downstream oncogenic signaling in HCC-827 and H3255 cell lines, leading to significant suppression of H3255 cancer cell proliferation.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.

Hydroxy-PEG6-Boc, a PEG-based PROTAC linker, is utilized in PROTAC synthesis [1].

N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl/ether.

Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Boc-NH-PEG4-CH2CH2NH2 is a cleavable 5-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker used in PROTAC synthesis.

Mal-PEG5-Boc (Mal-PEG5-COOtBu) is a PEG-based PROTAC linker. Mal-PEG5-Boc can be used in the synthesis of PROTACs.

Propargyl-PEG5-Ms (Propargyl-PEG6-Ms) is a PEG-based PROTAC linker. Propargyl-PEG5-Ms can be used in the synthesis of PROTACs.

Amino-PEG5-amine, a PEG-based linker containing 5 units, is utilized in PROTAC synthesis.

Azido-PEG5-alcohol, a non-cleavable 5 unit polyethylene glycol (PEG) ADC linker, finds application in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

Bis-PEG5-acid (PROTAC Linker 36) is a polyethylene glycol (PEG) linker used in the synthesis of CP5V, a PROTAC that selectively degrades Cdc20[1].

Bis-propargyl-PEG6 is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during the synthesis of PROTACs. Its application includes the generation of polymer-linked multimers of guanosine-3', 5'-cyclic monophosphates[1].

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.

HOOCCH2O-PEG4-CH2COOH (compound 5), is a symmetric polyethylene glycol (PEG) linker. It is primarily utilized in the synthesis of the initial Homo-PROTAC[1] compound.

Methyltetrazine-PEG5-NHS ester is a PROTAC linker belonging to the group of PEGs and is used for the synthesis of PROTAC molecules.

NH2-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized for the synthesis of PROTACs[1]. It is a 5-unit PEG ADC linker that is non-cleavable, and employed in the synthesis of antibody-drug conjugates (ADCs)[2].

Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].

5-endo-BCN-pentanoic acid, an alkyl chain-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Azido-PEG5-azide, a PEG-based PROTAC linker, is used in PROTAC synthesis.

Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide based cereblon ligand and 3-unit PEG linker.

cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].