mglu3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13318	VU0650786		GluR
	VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.		GluR
T6022	LY404039	pomaglumetad	Glucocorticoid Receptor , GluR
	LY404039 (pomaglumetad) is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).		Glucocorticoid Receptor , GluR
T23003	ML337	ML 337	GluR
	ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.		GluR
T3010	Xanthurenic Acid	8-Hydroxykynurenic acid,4,8-Dihydroxyquinaldic acid,xanthurenate	Apoptosis , Endogenous Metabolite , GluR
	Xanthurenic Acid (8-Hydroxykynurenic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3).		Apoptosis , Endogenous Metabolite , GluR
T23000	ML289	VU0463597,ML 289	GluR
	ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), demonstrating over 15-fold selectivity compared to mGlu2 and showing no activity against mGlu5.		GluR
T22204	LY 2389575 hydrochloride		Beta Amyloid , GluR
	LY2389575 hydrochloride is an mGlu3 negative allosteric modulator (NAM) that is selective and non-competitive, with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1, which amplifi...		Beta Amyloid , GluR
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
T38990	MGS0274
	MGS0274, an ester-based lipophilic prodrug of the metabotropic glutamate (mGlu)2 and mGlu3 receptor agonist MGS0008, demonstrates enhanced oral bioavailability and holds promise for schizophrenia research applications.
T15807	LY2794193		SGLT
	LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927 nM,EC50=0.47 nM; hmGlu2 Ki=412 nM,EC50=47.5 nM).		SGLT
T15809	LY2812223		LIM Kinase
	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).		LIM Kinase
T15817	Eglumegad	Eglumetad,LY354740	Others
	Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).		Others
T61070	VU6010572
	VU6010572 is a highly potent and selective negative allosteric modulator of mGlu3, exhibiting an IC50 of 245 nM. Additionally, VU6010572 displays high central nervous system penetrance [1] [2].
T11906	LY 541850		GluR
	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expres...		GluR
T78094	Eglumegad hydrochloride	LY354740 hydrochloride,Eglumetad hydrochloride
	Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, exhibiting IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors when transfected into human cells. This compound ...
T62756	LY487379
	LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). lY487379 enhances glutamate-stimulated [35 S] GTPγS binding to mGlu2 receptors (EC50: 1.7 μM) and mGlu3 receptors (EC50>10 μM). lY487379 induces c...