isodon

Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. Effusanin A shows inhibitory effects on DU145 cells with IC50 value of 3.16 micro

Isodonal shows abilities to inhibit K562 cells camparable to that of cisplatin.

D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.

Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

Lumichrome is an endogenous compound in humans, produced by photodegradation of riboflavin. It utilizes a p53-dependent mechanism to inhibit growth and induce apoptosis in human lung cancer cells.

Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.

Longikaurin E ((-)-Longikaurin E) is a therapeutic agent for pancreatic cancer. It is isolated from Isodon adenolomus.

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens that exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma cells, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on the protein levels of JAK2 and STAT3.

Macrocalyxin C is extracted from the stems and leaves of Isodon albopilosus.

(-)-vibo-Quercitol ((-)-Viburnitol) is a carbaglycosylamine glycosidase inhibitor.

1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

Maoecrystal A is a natural compound isolated from the leaves of I. eriocalyx with anti-inflammatory, antioxidant and antibacterial activity.

During hypoxia in rats, levels of α-tocopherylquinon have been found to rise. alpha-Tocopherolquinone (Metarene) is reported to downregulate the respiratory activity of mitochondria. alpha-Tocopherolquinone has also displayed antioxidant activities after it is reduced to tocopherylhydroquinone.

Xerophilusin B, isolated from Isodon xerophilus as an anticancer agent, demonstrates antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines. It induces G2/M cell cycle arrest and mediates apoptosis [1].

Inflexuside B, an abietane diterpenoid derived from the aerial parts of Isodon inflexus, effectively inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages [1].

Inflexuside A, an abietane diterpenoid isolated from the aerial parts of Isodon inflexus, and Inflexuside B significantly inhibit lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages [1].

Xerophilusin A, an ent-kaurane diterpenoid, is extractable from the aerial parts of Isodon enanderianus [1].

Xerophilusin G is a natural product of Isodon, Lamiaceae. The catalog number is TMA1742 and the CAS number is 304642-94-2. Xerophilusin G can be used as a reference standard.

Ergosterol peroxide (NSC 31324) is a derivative from mushrooms with anti-tumor, pro-apoptotic anti-mycobacterial and anti-proliferative activities.Ergosterol peroxide has anti-inflammatory and antioxidant activities and is toxic to parasites.

Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl rosmarinate and Pedalitin are mixed-type inhibitors.

Siegesbeckiol (Compound 5) is a sesquiterpene compound that can be extracted from Isodon flavidus.

Enmein shows significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml

DL-alpha-Tocopherylacetate ((±)-Vitamin E acetate) is an oral tocopherol supplement with antioxidant activity.

Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inhibitor of STAT3, it directly target