hydrolases — TargetMol Chemicals

Cat No.	Product Name	Targets
T9753	LEI110	Phospholipase
	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).	Phospholipase
T15802	LY2183240	FAAH , Autophagy
	LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).	FAAH , Autophagy
T10623	BSH-IN-1	Potassium Channel
	BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B. longum BSH and B. theta BSH).	Potassium Channel
T8997	WWL229	Others
	WWL229 is a selective inhibitor of Ces3 . WWL229 acts by inhibiting recombinant Ces3 but not Ces1f, ABHD6 or other tested serine hydrolases, and recapitulating the effects of WWL113 in adipocytes.	Others
T68626	JCP678
	JCP678 is an irreversible serine hydrolases inhibitor.
T37227	(±)8(9)-DiHET
	Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy f...
T76110	β-Glucosidase
	β-Glucosidase, a pivotal enzyme in cellulose degradation, belongs to the extensive family of glycoside hydrolases. It plays a crucial role in breaking down cellulose in soils and holds promise for assessing biological so...
T74878	Enzyme-IN-1
	Enzyme-IN-1 (compound 1), a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases, specifically targets and inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. This compound may possess pot...
T71525	AB05831
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis...
T76100	Maltose phosphorylase
	Maltose phosphorylase, a dimerase belonging to family 65 of the glycoside hydrolases [1], catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.
T37242	(±)5(6)-DiHETE
	Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils. EPA is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vici...
T37243	(±)5(6)-DiHETE lactone
	Eicosapentaenoic acid is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE is a possible metabolite produced from EPA fo...
T73317	JZP-MA-13
	JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor, demonstrating impressive specificity with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty ac...
T36838	(R)-Bromoenol lactone
	The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily...
T76123	Carboxylesterase
	Carboxylesterases (CESs), carboxylate hydrolases broadly distributed in nature and prevalent in mammalian liver, play a significant role in biochemical research. These enzymes facilitate the hydrolysis of diverse substra...
T37333	(±)11(12)-DiHET MaxSpec® Standard
	(±)-11(12)-DiHET is an oxylipin. 11(S),12(S)-DiHET and 11(R),12(R)-DiHET are vicinal diols formedviaenzymatic hydration of 11(12)-EET by cytosolic or soluble epoxide hydrolases in a non-stereoselective manner.1,2,3(±)11(...
T38143	Elaidamide
	Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu...