hsv

This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.

Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects.

N-Lauroylsarcosine is an amphiphilic anionic surfactant derived from sarcosine , commonly used as a foaming agent and detergent for the preparation of ph-sensitive vesicles and micellar aggregates with antiviral activity against HSV.

Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity. It reduces recurrent lesions caused by HSV-2, alleviates radiation-induced oral mucositis, and inhibits the homodimerisation of STAT3 molecules in the cytoplasm.

FSL-1 TFA, a toll-like receptor 2/6 (TLR2/6) agonist derived from bacteria, bolsters resistance against experimental HSV-2 infection[1] and stimulates MMP-9 production via the TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2].

HHV-2 Envelope Glycoprotein G (552-574), an immunodominant region within glycoprotein G (gG-2), demonstrates reactivity with all herpes simplex (HSV-2) sera [1].

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescein isothiocyanate (FITC)-labeled segment of the HHV-2 Envelope Glycoprotein G encompassing amino acids 561 to 578. This immunodominant region of glycoprotein G (gG-2) exhibits reactivity with all herpes simplex virus type 2 (HSV-2) sera [1].

GLR-19 is an anti-HIV peptide with demonstrated antiviral activity against HSV-2 [1] [2].

HBA(111-142), a C-terminal 32-mer fragment of alpha-hemoglobin, exhibits antibacterial activity against the ESKAPE panel of pathogens, forms amyloid fibrils, and possesses antiviral activities, notably inhibiting the measles virus and herpes viruses (HSV-1, HSV-2, HCMV) [1].

Histone H4 (2-21) is a crucial core histone essential for the chromatinization of herpes simplex virus 1 (HSV-1) genomes.

ATV041, an orally active compound that combines features of Ibuprofen and nucleotide analogues, enhances the oral pharmacokinetic (PK) profile and tissue distribution, exhibiting anti-mouse hepatitis virus (MHV) activity. The compound demonstrates a dose-dependent reduction in viral load, tissue damage, and virus-induced inflammation [1].

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

Astodrimer (SPL7013 free base), a large (3-4 nm, ~16.5 kDa) and negatively charged dendrimer, possesses potent virucidal capabilities. Exhibiting antiviral and virucidal activities, it effectively targets a wide array of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, and HPV. Additionally, Astodrimer demonstrates antibacterial properties [1] [2] [3].

XQ2B is a cGAS inhibitor that impedes protein-DNA interactions and phase separation. It suppresses antiviral immune responses induced by herpes simplex virus 1 (HSV-1) and augments HSV-1 infection in both in vitro and in vivo settings [1].

Retrocyclin-3 is an antimicrobial peptide exhibiting activity against human immunodeficiency virus (HIV), influenza A, and herpes simplex virus (HSV) [1].

Retrocyclin-2 is an antimicrobial peptide effective against human immunodeficiency virus (HIV), influenza A, and herpes simplex virus (HSV) [1].

Bovine Myeloid Antimicrobial Peptide (BMAP) 28, a synthetic peptide derived from bovine cathelicidin-5 (amino acids 132-158), exhibits antimicrobial activity against E. coli, S. aureus, MRSA, S. epidermidis, and the fungus C. albicans, with minimum inhibitory concentrations (MICs) of 2, 2, 4, 1, and 8 µM respectively. At a concentration of 200 nM, BMAP 28 permeabilizes the inner membrane of E. coli, and at 5 µM, it inhibits herpes simplex virus 1 (HSV-1) replication in Vero 76 cells. Furthermore, at 30 µM, it causes hemolysis in human erythrocytes and cytotoxicity in human neutrophils. In vivo, a dose of 0.8 mg/kg enhances survival in mice infected with E. coli or MRSA, but not P. aeruginosa.

DX-236 is a macrocyclic peptide with a binding affinity of 1.9 µM for human serum albumin (HSA). DX-236 can merge with [HSV], thereby extending its circulation time in vivo.

Temporin-Sha is an antimicrobial peptide known for its broad-spectrum biological activity. It is effective against Gram-positive bacteria (such as Listeria, MIC= 6.25 μM), Gram-negative bacteria (such as Escherichia coli, MIC= 10 μM), and resistant strains like Methicillin-resistant Staphylococcus aureus. Additionally, Temporin-Sha inhibits Candida albicans (MIC= 25 μM), Saccharomyces cerevisiae (MIC= 12 μM), Leishmania promastigotes and amastigotes (IC50= 9-20 μM), and Trypanosomes (IC50= 17 μM). It also exhibits antiviral activity against HSV-1 and shows anticancer properties, displaying cytotoxicity towards breast cancer cells MCF-7 and lung cancer cells H460.