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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38766L | Histone H3 (1-35) acetate | Others | |
Histone H3 (1-35) acetate is a 35-residue peptide of histone H3. Histone H3 is an important protein that plays a role in the dynamic and long term regulation of genes. | |||
T11563 | Histone Acetyltransferase Inhibitor II | Epigenetic Reader Domain , Histone Acetyltransferase | |
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. | |||
T2157 | M344 | MS 344,Histone Deacetylase Inhibitor III | HDAC |
M344 (Histone Deacetylase Inhibitor III) is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. | |||
T40407 | Histone H3 (5-23) | Histone H3 (5-23) | |
Histone H3 (5-23), a derivative of histone H3 consisting of amino acids 5-23, serves as a substrate for histone acetyltransferase (HAT) assays. | |||
T40993 | Histone H3 (1-21) | Histone H3 (1-21) | |
Histone H3 (1-21) is a truncated form of the Histone H3 protein consisting of amino acids 1 to 21. It serves as a common substrate for methyltransferase assays targeting Histone 3 at lysine 4 and lysine 9, as well as for... | |||
T38766 | Histone H3 (1-35) | Histone H3 (1-35) | |
Histone H3 (1-35) is a 35-residue peptide derived from histone H3, which is a key member of the five main histones participating in the formation of chromatin within eukaryotic cells. | |||
T39580 | Histone H3 (23-34) | Histone H3 (23-34) | |
Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylati... | |||
T38785 | Histone H3 (21-44) | Histone H3 (21-44) | |
Histone H3 (21-44), derived from a sequence of 21-44 amino acids of histone H3, is commonly employed as a substrate, particularly for protein arginine methyltransferase assays, where methylation activity is being examine... | |||
T41019 | Histone H1-derived Peptide | Histone H1-derived Peptide | |
Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs). | |||
T38784 | Histone H3 (1-25), amide | Histone H3 (1-25), amide | |
Histone H3 (1-25), amide is a N-terminal peptide fragment of histone H3 that serves as a substrate for histone methyltransferases (HMTs). It can be utilized to identify the substrate for HMTs. Compared to histone H3 (15-... | |||
T36980 | Histone H3K27Me1 (23-34) (trifluoroacetate salt) | Histone H3K27Me1 (23-34) (trifluoroacetate salt) | |
Histone H3K27Me1 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Monomethylation of histone H3 at lysine 27 is associated with activ... | |||
T77560 | Histone acetyltransferase p300 Inhibitor 4c | Carbonic Anhydrase , AChE | |
Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.03... | |||
T41061 | Histone H3 (116-136), C116-136 | Histone H3 (116-136), C116-136 | |
Histone H3 (116-136), C116-136 is a peptide consisting of amino acids 116 to 136, which spans the C-terminus of histone H3. | |||
T36576 | Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) | Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) | |
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44... | |||
T3206 | NKL 22 | Histone Deacetylase Inhibitor IV,PAOA | HDAC |
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. | |||
T36979 | Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) | Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) | |
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3... | |||
T36095 | Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) | Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) | |
Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) can be used in related research in the field of life sciences, and its product number is T36095. | |||
T36577 | K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) | K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) | |
Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker.... | |||
TP1536 | Histone H4 (2-21) | ||
Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1). | |||
TP2257 | Histone-H2A-(107-122)-Ac-OH | Others | |
Histone-H2A-(107-122)-Ac-OH is a peptide with the sequence Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH, MW= 1762.1. Histone H2A is one of the five main histone proteins involved in the structure... | |||
T3193 | Pimelic diphenylamide 106 | Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 | HDAC |
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs. | |||
T64592 | Histone H3 Antibody #9715R | ||
Histone H3 Antibody #9715R is a useful organic compound for research related to life sciences and the catalog number is T64592. | |||
T64611 | Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R | ||
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R is a useful organic compound for research related to life sciences and the catalog number is T64611. | |||
T76381 | H1-7 (histone H1 phosphorylation site), PKA Substrate | ||
H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2]. | |||
T16435 | PBIT | Histone Demethylase , Histone Methyltransferase | |
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (J... | |||
T9243 | PFI-90 | Histone Demethylase , Others | |
PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death. | |||
T3499 | Remodelin | Histone Acetyltransferase | |
Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10. | |||
T11807 | L002 | Others , Histone Acetyltransferase , STAT | |
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ... | |||
T8344 | CPTH2 | Apoptosis , Histone Acetyltransferase | |
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network. | |||
T1819 | Nexturastat A | HDAC | |
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs. | |||
T6327 | Tubacin | Virus Protease , HDAC | |
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1. | |||
T5347 | CXD101 | CXD-101 | HDAC |
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II | |||
T7664 | Pyroxamide | Apoptosis , HDAC | |
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM). | |||
T8778 | TTK21 | Epigenetic Reader Domain | |
TTK21 is an activator of CBP/p300 histone acetyltransferase activity. | |||
T9745 | Elevenostat | HDAC | |
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM. | |||
T16129 | MPI_5a | HDAC | |
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM). | |||
T6055 | Quisinostat | JNJ-26481585 | Apoptosis , HDAC , Autophagy |
Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against... | |||
T5830 | SKLB-23bb | HDAC | |
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability. | |||
T12098 | MOZ-IN-2 | Histone Acetyltransferase | |
MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM). | |||
T1905 | EPZ005687 | Histone Methyltransferase | |
EPZ005687 is a potent and selective inhibitor of EZH2. | |||
T6900 | MS023 | Histone Methyltransferase | |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. | |||
T3084 | SGC707 | Histone Methyltransferase | |
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3. | |||
T7089 | SGC2085 | Histone Methyltransferase | |
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM). | |||
T7403 | BAY-598 | Histone Methyltransferase | |
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM. | |||
T1775 | GSK503 | Histone Methyltransferase | |
GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. | |||
T2435 | EPZ011989 | Histone Methyltransferase | |
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase. | |||
TQ0100 | AZ505 | Histone Methyltransferase | |
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM). | |||
T15194 | EBI-2511 | Histone Methyltransferase | |
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines). | |||
T4021 | UNC3866 | Histone Methyltransferase | |
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen. | |||
T15201 | MAK683 | Histone Methyltransferase | |
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8201 | Gambogenic acid | Histone Methyltransferase | |
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity. | |||
T6803 | Chaetocin | Histone Methyltransferase , Antibacterial , Antibiotic | |
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. | |||
T3719 | Daminozide | Succinic Acid,DMASA,Aminozide | Histone Demethylase |
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. | |||
TQ0207 | Sulforaphane | Apoptosis , Nrf2 , HDAC | |
Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities. | |||
T7052 | Gnetol | Tyrosinase , COX , HDAC , AChR | |
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ... | |||
T2266 | SantacruzaMate A | CAY-10683 | HDAC |
SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor. | |||
T11366 | Garcinol | Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE | |
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone... | |||
T6270 | Trichostatin A | TSA | HDAC |
Trichostatin A (TSA) is a natural derivative of diene isohydroxamic acids. Trichostatin A is a histone deacetylase inhibitor (IC50=1.8 nM) that is reversible and specific. Trichostatin A leads to the hyperacetylation of ... | |||
TN1150 | Procyanidin B3 | Histone Acetyltransferase | |
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. | |||
TN1911 | Marein | transporter , Akt , HDAC , AMPK | |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ... | |||
T5368 | Eicosapentaenoic Acid | Histone Demethylase , Others , Endogenous Metabolite | |
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms. | |||
T3753 | Sinapinic Acid | Sinapic acid,Synapoic acid | Apoptosis , RAAS , Reactive Oxygen Species , HDAC |
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap... | |||
T6389 | Anacardic Acid | 6-pentadecylsalicylic Acid,Hydroginkgolic acid | Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial |
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland... | |||
T6S0033 | Crotonoside | Isoguanosine,2-HYDROXYADENOSINE | Others , FLT , HDAC |
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stim... | |||
T0065 | Acetaminophen | 4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol | COX , Endogenous Metabolite , Histone Acetyltransferase |
Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity. | |||
T1516 | Curcumin | Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow | Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy |
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant... | |||
T7064 | Valproic Acid | Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy |
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research. | |||
T64353 | 4-tert-Octylphenol | Endogenous Metabolite | |
4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), m... | |||
T3878 | Raddeanin A | NSC382873,Anemodeanin A,Raddeanin R3 | Apoptosis , HDAC |
Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity. | |||
T14305 | Apicidin | OSI 2040 | Apoptosis , HDAC , Autophagy |
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis ... | |||
T37067 | 9-hydroxy Stearic Acid | HDAC | |
9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (... | |||
TN1567 | Delphinidin chloride | Estrogen Receptor/ERR , VEGFR | |
Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va... | |||
T13749 | L-2-Hydroxyglutaric acid | (S)-2-Hydroxyglutaric acid | Others |
L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Ad... | |||
T36797 | 1-Alaninechlamydocin | ||
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a conc... | |||
T70778 | Depudecin | ||
Depudecin is a polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone de... | |||
T75767 | Parasin I TFA | ||
Parasin I (TFA), a peptide derived from the 19 amino acids of histone H2A and isolated from catfish skin, exhibits antimicrobial activity [1]. | |||
TN2646 | 16-Hydroxycleroda-3,13-dien-15,16-olide | Autophagy | |
16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or alternative medicine for cancer therapy. 16-Hydroxycleroda-3,13-d... | |||
T5066 | Nε,Nε,Nε-Trimethyllysine chloride | Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride | Others , Endogenous Metabolite |
Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) is a methylated derivative of the amino acid lysine. It is a component of histone proteins, a precursor of carnitine and a coenzyme of fatty acid oxidation. Nε,Nε,... | |||
TN3070 | 4beta-Hydroxywithanolide E | PARP , HSP , NF-κB , COX | |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02580 | Histone H1 Protein, Human, Recombinant (His) | Human | E. coli |
H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "... | |||
TMPY-02521 | HIST3H2A Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident ... | |||
TMPY-04092 | Histone H4 Protein, Human, Recombinant | Human | E. coli |
Histone H4 Protein, Human, Recombinant is expressed in E. coli. The predicted molecular weight is 11.4 kDa. Accession number: B2R4R0 | |||
TMPY-02317 | HDAC8 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzym... | |||
TMPY-01332 | HIST1H3A Protein, Human, Mouse, Recombinant | Human,Mouse | E. coli |
Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expresse... | |||
TMPY-03341 | ASF1B Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the ... | |||
TMPY-01708 | DOT1L Protein, Human, Recombinant | Human | E. coli |
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil... | |||
TMPH-03487 | DNA-binding protein H-NS Protein, SerRatia marcescens, Recombinant (His) | Serratia marcescens | E. coli |
A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensi... | |||
TMPY-01333 | HDAC8 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzym... | |||
TMPH-02105 | ASH2L Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 ... | |||
TMPY-03431 | HDAC4 Protein, Human, Recombinant (aa 612-1084) | Human | Baculovirus-Insect Cells |
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups ... | |||
TMPJ-01399 | ASF1A Protein, Human, Recombinant (His, T7) | Human | E. coli |
Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chrom... | |||
TMPY-02510 | HIST2H2BE Protein, Human, Recombinant | Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and... | |||
TMPH-00616 | DNA-binding protein H-NS Protein, E. coli, Recombinant (His) | E. coli | E. coli |
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstrea... | |||
TMPH-00009 | OGT Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc... | |||
TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... | |||
TMPY-00021 | PADI4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase f... | |||
TMPY-02590 | HMGB1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas... | |||
TMPY-01848 | HMGB1 Protein, Human, Recombinant (aa 1-215, His) | Human | HEK293 |
High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas... | |||
TMPH-01622 | KDM3B Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activ... | |||
TMPH-03748 | KAT14 Protein, Human, Recombinant (His) | Human | E. coli |
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltrans... | |||
TMPH-02311 | WDR5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histon... | |||
TMPH-01698 | MORC4 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2... | |||
TMPY-01657 | SUV420H2 Protein, Human, Recombinant (His & GST) | Human | E. coli |
Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-ly... | |||
TMPH-01803 | NAP1L4 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Acts as histone chaperone in nucleosome assembly. | |||
TMPY-01229 | SETD7 Protein, Human, Recombinant (His) | Human | E. coli |
Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine ... | |||
TMPY-03498 | ING4 Protein, Human, Recombinant (His) | Human | E. coli |
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling... | |||
TMPY-02981 | ING5 Protein, Human, Recombinant (GST) | Human | E. coli |
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is re... | |||
TMPY-05251 | RbAp48 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling fac... | |||
TMPY-01713 | RbAp48 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling fac... | |||
TMPH-00668 | DNA-binding protein HU-alpha Protein, E. coli O157:H7, Recombinant (His & SUMO) | E. coli | E. coli |
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | |||
TMPH-03040 | HupB Protein, MenB, Recombinant (His) | MenB | E. coli |
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | |||
TMPH-01319 | EYA2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes... | |||
TMPH-02227 | ERG Protein, Human, Recombinant (His) | Human | Yeast |
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. | |||
TMPH-01088 | CBX5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphor... | |||
TMPH-03471 | HupB Protein, Salmonella typhi, Recombinant (His & Myc & SUMO) | Salmonella typhi | E. coli |
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | |||
TMPH-01697 | MORC3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in ... | |||
TMPH-01886 | BMI-1 Protein, Human, Recombinant (GST) | Human | E. coli |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex... | |||
TMPH-01089 | CBX7 Protein, Human, Recombinant (His) | Human | E. coli |
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex... | |||
TMPH-01776 | HMGN2 Protein, Human, Recombinant (GST) | Human | E. coli |
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. | |||
TMPH-00089 | SPT16 Protein, Arabidopsis thaliana, Recombinant (His & SUMO) | Arabidopsis thaliana | E. coli |
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication an... | |||
TMPH-01742 | SIRT6 Protein, Human, Recombinant (GST) | Human | E. coli |
NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis. Has very weak deacetylas... | |||
TMPH-02221 | TRIM24 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high... | |||
TMPY-00398 | Cardiotrophin 1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CTF1 is the first HOX11 protein partner identified that plays an important role in hematopoietic precursor cell immortalization. CTF1 was found to protect a gene from silencing when its DNA-binding sites were interposed ... | |||
TMPY-03917 | Cardiotrophin 1 Protein, Human, Recombinant | Human | HEK293 |
CTF1 is the first HOX11 protein partner identified that plays an important role in hematopoietic precursor cell immortalization. CTF1 was found to protect a gene from silencing when its DNA-binding sites were interposed ... | |||
TMPH-00095 | HDT2 Protein, Arabidopsis thaliana, Recombinant (His) | Arabidopsis thaliana | Yeast |
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcr... | |||
TMPH-01352 | FOXP3 Protein, Human, Recombinant (His) | Human | E. coli |
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of ... | |||
TMPY-02379 | EED Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. EED depletion significantly impeded erythroid maturation. EED depletion imp... | |||
TMPH-01654 | MAGEA1 Protein, Human, Recombinant (His) | Human | Yeast |
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal developmen... | |||
TMPY-03283 | HBP1 Protein, Human, Recombinant (GST) | Human | E. coli |
HBP1 is a sequence-specific DNA-binding transcription factor. It is involved in many biological processes. It was reported that HBP1 binds to p16(INK4A) promoter and activates p16(INK4A) expression. We found that trichos... | |||
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Cat No. | Product Name | ||
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L3500 | Histone Modification Compound Library | 480 compounds | |
A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L3510 | Methylation Compound Library | 131 compounds | |
131 methylation-related compounds that can be used for high-throughput and high-content screening. | |||
L8300 | Chromatin Modification Compound Library | 256 compounds | |
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS); | |||
L1200 | Epigenetics Compound Library | 960 compounds | |
Well-chosen 960 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L8000 | Stem Cell Differentiation Compound Library | 1213 compounds | |
A unique collection of 1213 stem cell differentiation signaling targeted compounds for high throughput and high content screening; |