hemorrhage — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14865	Carboprost tromethamine		Prostaglandin Receptor
	Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.		Prostaglandin Receptor
T21902	ML351		Lipoxygenase
	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).		Lipoxygenase
T4552	Fursultiamine	Diteftin,Judolor,Alinamin F	Others
	Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.		Others
T7601L	Carbetocin acetate	Carbetocin acetate(37025-55-1 free base)	Oxytocin Receptor
	Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.		Oxytocin Receptor
T15247	ESI-05	NSC 116966	cAMP
	ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.		cAMP
T11571	HLY78	4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.		Wnt/beta-catenin
T22285	Carboprost	15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α	Prostaglandin Receptor
	Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone.		Prostaglandin Receptor
T7601	Carbetocin		Oxytocin Receptor
	Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.		Oxytocin Receptor
T70470	CM-352		MMP
	CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.		MMP
T8857	LJP-1586 HCl	LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586	Others
	LJP-1586 HCl, a highly selective inhibitor of vascular adhesion protein-1 (VAP-1), exhibits antiinflammation effect by reducing adhesion molecule expression and immune cell infiltration after intracerebral hemorrhage (IC...		Others
T11662L	INT-777	S-EMCA	GPCR19
	INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats...		GPCR19
T66582	6-Methylnicotinamide		Endogenous Metabolite
	6-Methylnicotinamide is a derivative of nicotinamide, an endogenous metabolite. 6-Methylnicotinamide is used to make co-crystals/salts. In the acute phase of cerebral hemorrhage (ICH), a sudden increase in 6-Methylnicoti...		Endogenous Metabolite
T3976	Cytosporone B	Csn-B,Dothiorelone G	Others
	Cytosporone B (Dothiorelone G) is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene...		Others
T50100	3-hydroxy-3-phenylpentanamide		Others
	3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In p...		Others
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T61677	PiCRAC-1
	piCRAC-1 is a powerful inhibitor of the photoinducible Ca2+ release-activated Ca2+ (CRAC) channel. It effectively alleviates thrombocytopenia and hemorrhage [1].
T11152	Edaravone-d5	MCI-186 D5	Others
	Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the origin...		Others
T38058	Cimetidine sulfoxide
	Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorr...
TP1953	PG-931	PG 931
	Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory ...
TN4937	Sambutoxin		Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, ...		Others