glycolipid

Glycolipids are lipids with a carbohydrate attached by a glycosidic (covalent) bond. Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response and in the connections that allow cells to connect to one another to form tissues.

Gingerglycolipid B is a useful organic compound for research related to life sciences. The catalog number is T124005 and the CAS number is 88168-90-5.

Gingerglycolipid A is a monoacyldigalactosyl glycerol.

α-Galactosylceramide (KRN7000) is a synthetic glycolipid with antitumorial and immunostimulatory and is a very potent NKT cell agonist and binds effectively to CD1d. The complex of α-Galactosylceramide and CD1d can bind to the T cell antigen receptor of NKT cells.

6,6′-Trehalose dioleate (6,6′-TDO) is a glycolipid extensively used for in vivo and in vitro mRNA delivery. This compound effectively encapsulates mRNA encoding hemagglutinin A (HA) from influenza A virus for use within lipid nanoparticles (LNPs), enhancing the secretion of Ifn-γ, Il-2, and Tnf-α from isolated murine spleen cells. When administered via intramuscular injection in mice, LNPs containing 6,6′-TDO predominantly accumulate in the liver and spleen. Unlike LNP formulations without 6,6′-TDO, those containing 6,6′-TDO do not reduce serum levels of blood urea nitrogen (BUN) or elevate levels of lactate dehydrogenase (LDH), troponin I, alanine aminotransferase (ALT), or aspartate aminotransferase (AST). Additionally, these LNPs enhance the serum titers of IgG1 and IgG2a antibodies in mice.

L 681217 is a glycolipid-type antibiotic related to the efrotomycin class. L-681217 inhibits bacterial protein synthesis at the elongation stage. L 681217 shows broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria.

L 644257 is a synthetic glycolipid for study liposomes in vivo.

Woodrosin I is a glycolipid.

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.

Tetracosanoyl-sulfatide is an endogenous sulfated glycolipid, which are also known as sulfatides . Tetracosanoyl-sulfatide is the major sulfatide in mature myelin in the central and peripheral nervous systems. Levels of Tetracosanoyl-sulfatide are elevated in plasma derived from patients with metachromatic leukodystrophy, a disorder characterized by arylsulfatase A deficiency, leading to sulfatide accumulation. Unlike C24:1 3'-sulfo galactosylceramide, it does not induce an immune response in mouse splenocytes in vitro.

SQDG, a membrane glycolipid characterized by sugar moieties in its head groups, is instrumental in studying the influence of structural lipids in LNP formulations [1].

Lacto-N-fucopentaose II (LNFP II), a sialyl-Lewis hapten of the human Lewis blood group determinant, acts as a monosialo-ganglioside glycolipid and sialyl derivative, CA 19-9, and is recognized as a molecular tumor marker (TM) for biliopancreatic malignancy [1].

BAY-R 1005, a synthetic glycolipid analogue (GLA) with immunoenhancing properties, is designed to modulate antibody synthesis [1].

10-Methyl palmitic acid methyl ester is a methylated derivative of fatty acid methyl ester, identified in glycolipid analogs with cyclitol from P. crassa. [Matreya, LLC. Catalog No. 1792]

AGI-134, a fully synthetic alpha-Gal glycolipid, invokes CD8+ T cell-mediated immunity and induces tumor cell destruction and phagocytosis [1].

Trehalose 6,6'-dimycolate (Cord Factor) is a cell wall glycolipid from Mycobacterium tuberculosis. It can simulate the inflammation and granuloma typical of Mycobacterium tuberculosis (MTB) infection. Additionally, Trehalose 6,6'-dimycolate shields Mycobacterium tuberculosis against macrophage-mediated eradication, inhibits effective antigen presentation, and diminishes the development of protective T cell responses [1] [2].

Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].

GCS-12, a Th1 2-balanced sulfonamide glycolipid, enhances its interaction with CD1d. It acts as an agonist for Natural Killer T cells (NKT cells), inducing the secretion of cytokines IFN-γ and IL-4. In mice, it has demonstrated immunoregulatory and antitumor activities.

Octadecylthioethyl 4-O-α-D-galactopyranosyl-β-D-galactopyranoside is a glycolipid receptor used to study lipid regulation mechanisms.