gena

GNE-203 is a Met inhibitor.

Higenamine hydrochloride (norcoclaurine HCl) has been demonstrated to be a β2 adrenoreceptor agonist. Adrenergic receptors, or adrenoceptors, belong to the class of G protein–coupled receptors, and are the most prominent receptors in the adipose membrane, besides also being expressed in skeletal muscle tissue.

Ethoxylated hydrogenated castor oil is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o w) emulsions.

5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile is a compound used as a molecular structural unit and is considered to be an inhibitor of enzymes such as COX-2, 5-LOX, etc., and possesses a wide range of biochemical and physiological effects including antitumor activity, anti-inflammatory effects and antioxidant activity.

Butylchlorogenate is a natural compound isolated from Lonicera japonica, Urceola rosea.

5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.

Heme Oxygenase-1-IN-1 (HO-1-IN-1) is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).

HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).

Chingchengenamide A is a useful organic compound for research related to life sciences and the catalog number is T125929.

12α-Hydroxysteroid dehydrogenase, an NAD-dependent enzyme expressed in Bacillus sphaericus, actively processes both free and conjugated bile salts. It is utilized to determine the levels of 12α-hydroxy bile acids in serum.

Sorbitol-6-phosphate 2-dehydrogenase, a dehydrogenase enzyme produced by Escherichia coli, catalyzes the interconversion of D-sorbitol 6-phosphate and D-fructose 6-phosphate. The enzyme oxidizes D-sorbitol 6-phosphate at a rate ten times faster than it reduces D-fructose 6-phosphate, playing a role in various cellular processes.

Galactose 1-dehydrogenase, pseudomonas fluorescens, a dehydrogenase found in Pseudomonas fluorescens, facilitates the oxidation of L-arabinose and D-galactose, utilizing NADP+ NAD+ as a cofactor. This enzyme is employed in diagnostic assays to quantify total galactose levels and serves as a biocatalyst in the production of galacturonic acid salts.

Collagenase Type II, an endopeptidic matrix metalloproteinase MMP-8 derived from the bacterium Clostridium histolyticum, preferentially degrades type I collagen and is commonly used in tissues requiring high digestive efficiency such as pancreas and liver.

Collagenase Type IV is an endopeptidic matrix metalloproteinase MMP-18 derived from the bacterium Clostridium histolyticum that primarily degrades collagen type IV and VII and is commonly used to break down basement membranes (e.g., neural tissue, renal tissue) because of its mild activity.

Collagenase Type III, an endopeptide matrix metalloproteinase MMP-13 derived from the bacterium Clostridium histolyticum, preferentially degrades type III collagen and is commonly used in sensitive tissues such as breast, tumor, and uterus due to its mild activity.

Collagenase Type V, an endopeptidic matrix metalloproteinase MMP from the bacterium Clostridium histolyticum, can be used for islet tissue isolation.

Collagenase, Type VI (EC 3.4.24.3) is an enzyme specialized in degrading Type VI collagen, a component found in various tissues including skin, heart, blood vessels, cartilage, and the cell membranes in synovia. Excessive activity of this enzyme can lead to extracellular matrix disorders. Additionally, Collagenase, Type VI serves as a biomarker for tumor invasion and metastasis. It acts specifically on peptide bonds between proline and glycine. Exploiting this specificity, modified electrodes can be used to rapidly and sensitively detect its concentration levels in experiments.

Collagenase, Type VII (EC 3.4.24.3), is an enzyme capable of inducing thalamic hemorrhage.

Collagenase, Type VIII, has the capability to hydrolyze Type VIII collagen, and may be utilized in the study of atherosclerosis development. Type VIII collagen serves as a regulator of endothelial cell differentiation and angiogenesis, acts as a substrate for the adhesion and migration of cells such as smooth muscle cells, and may accumulate in atherosclerosis. Following the activation by endotoxins, the expression of Collagenase, Type VIII can reduce the production of Type VIII collagen, potentially inhibiting the progression of atherosclerosis.

Succinate dehydrogenase-IN-4 (Compound 4b) is an inhibitor of succinate dehydrogenase with an IC50 value of 3.38 μM. It exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare, with EC50 values of 16.33 μM and 18.06 μM, respectively.

Succinate dehydrogenase-IN-5 (Compound M8) acts as an inhibitor of succinate dehydrogenase. It disrupts energy metabolism and growth in fungi and is effective against Rhizoctonia solani, Sclerotinia sclerotiorum, Botrytis cinerea, and Fusarium graminearum, with an EC50 of less than 0.3 μg mL.

Collagenase (Type B, animal free) is devoid of animal-derived components and exhibits enhanced collagenase and caseinase activities.

Succinate dehydrogenase-IN-7 (Compound 2f) is a succinate dehydrogenase inhibitor with an IC50 value of 2.51 μM and exhibits bactericidal properties.

Collagenase (Type D, animal free) lacks animal-derived components and exhibits collagenase and secondary protease activities similar to that of Type 1 and Type 2 collagenase. The enzymatic activity of Collagenase (Type D, animal free) surpasses that of Collagenase (Type A, animal free).