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Results for "

g0/g1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    119
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • PROTAC Products
    5
    TargetMol | PROTAC
  • Natural Products
    14
    TargetMol | Natural_Products
  • Recombinant Protein
    7
    TargetMol | Recombinant_Protein
  • Antibody Products
    10
    TargetMol | Antibody_Products
PR-619
PR 619, 2,6-Diamino-3,5-dithiocyanopyridine
T18622645-32-1
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor that inhibits USP2 4 5 7 8 (EC50=7.2 3.93 8.61 6.86 4.9 μM). PR-619 induces endoplasmic reticulum stress and activates autophagy.
  • $45
In Stock
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TargetMol | Inhibitor Sale
Mevastatin
ML236B, Compactin
T068373573-88-3
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
  • $51
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ZINC00784494
ZINC 00784494
T78149317328-17-9
ZINC00784494 is a selective inhibitor of LCN2 (lipocalin-2), which inhibits cancer cell proliferation and reduces AKT phosphorylation levels, prevents the transition of the cell cycle from the G0 G1 phase to the S phase, and promotes apoptosis. It can be used for the study of inflammatory breast cancer (IBC).
  • $70
In Stock
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Iberdomide
CC-220
T77911323403-33-3
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
  • $39
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Ailanthone
Δ13-Dehydrochaparrinone
TQ0209981-15-7
Ailanthone (AIL) is a natural compound derived from the tree Ailanthus altissima and has anti-hepatocellular carcinoma (HCC) properties. It can induce G0 G1 phase cell cycle arrest by downregulating the expression of cyclins and CDKs, while upregulating the expression of p21 and p27. Additionally, Ailanthone is a potent androgen receptor (AR) inhibitor, capable of inhibiting both the full-length androgen receptor (IC50: 69 nM) and constitutively active splice variants (IC50: 309 nM).
  • $36
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EGFR-IN-11
T111582463200-44-2
EGFR-IN-11 is a selective inhibitor of EGFR-tyrosine kinase and induces cell apoptosis. EGFR-IN-11 inhibits triple mutant EGFRL858R T790M C797S with an IC50 of 18 nM and arrests cell cycle at G0 G1.
  • $33
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TargetMol | Inhibitor Sale
σ1 Receptor antagonist-1
T92441204401-49-9
σ1 Receptor antagonist-1 is a selective σ1 receptor antagonist.
  • $35
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TargetMol | Inhibitor Sale
Meisoindigo
Natura-α, Dian III, Methylisoindigotin, N-Methylisoindigotin
T188297207-47-1
Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
  • $64
In Stock
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PROTAC FGFR2 degrader 1
T200117
PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0 G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.
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Sampangine
T200281116664-93-8
Sampangine, an alkaloid, induces apoptosis by causing cell cycle arrest at the G0 G1 phase and inhibits the biosynthesis of heme.
  • $1,520
6-8 weeks
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JND4135
T2002912366216-76-2
JND4135, a type II TRK inhibitor, exhibits IC50 values targeting TRKA, TRKB, and TRKC at 2.79, 3.19, and 3.01 nM, respectively. It can overcome resistance due to TRKxDFG and other mutations in the BaF3 stable model, inhibiting the phosphorylation of TRKs WT, xDFG mutations, and their downstream signaling molecules. Additionally, JND4135 induces G0 G1 phase arrest and cell apoptosis (apoptosis) in BaF3–CD74-TRKA-G667C cells. This compound also demonstrates antitumor activity in a BaF3-CD74-TRKA-G667C mouse xenograft model by suppressing tumor growth.
  • $2,270
3-6 months
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c-Met/HDAC-IN-4
T200367
c-Met HDAC-IN-4, a dual inhibitor of c-Met HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.
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FAK inhibitor 7
T2004442890814-94-3
FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0 G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.
  • $1,520
6-8 weeks
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SILA-123
T2004982911585-37-8
SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0 G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.
  • $2,120
10-14 weeks
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GP130-IN-1
T2006072955243-69-1
GP130-IN-1 (compound 49) is an effective inhibitor of GP130, demonstrating significant in vitro anti-tumor activity and higher selectivity compared to Bazedoxifene. It induces ultrastructural changes in cells, leading to a time-dependent arrest of the cell cycle at the G0 G1 phase, and triggers both apoptosis and autophagy. GP130-IN-1 is useful for research on triple-negative breast cancer.
  • $1,520
4-6 weeks
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PARP1/BRD4-IN-3
T200653
PARP1 BRD4-IN-3 (compound HF4) is an effective inhibitor of BRD4 and PARP1, with IC50 values of 1210 nM and 2019 nM respectively. The compound exhibits antiproliferative activity, induces apoptosis (apoptosis) and cell cycle arrest at the G0 G1 phase. Additionally, PARP1 BRD4-IN-3 causes DNA damage and reduces the expression of the Rad51 protein, demonstrating anti-tumor activity.
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PROTAC EZH2 Degrader-3
T200955
PROTAC EZH2 Degrader-3 (compound ZJ-20) is a potent EZH2 degrader that exhibits strong inhibitory effects not only on EZH2 protein expression but also on the levels of other PRC2 subunits and H3k27me3 protein. Additionally, PROTAC EZH2 Degrader-3 demonstrates antiproliferative activity by blocking the cell cycle at the G0-G1 phase and inducing apoptosis (cell death). At a concentration of 5 μM and over a period of 24 hours, it effectively suppresses the expression of these critical proteins involved in cell regulation and growth.
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DH-18
T200984
DH-18 is an inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting IC50 values of 139.45 nM for MMP-2, 518.11 nM for MMP-9, and 833.34 nM for MMP-8. The compound promotes cell apoptosis and causes cell cycle arrest in the G0 G1 phase. DH-18 also inhibits cell growth, making it potential for research in chronic myeloid leukemia.
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PROTAC c-Met degrader-1
T2010573056647-52-7
PROTACc-Met degrader-1 (Compound Met-DD4) is an orally effective PROTAC degrader targeting c-Met with a DC50 of 6.21 nM. It inhibits the proliferation of c-Met-addicted MKN-45 cells with an IC50 of 4.37 nM and causes cell cycle arrest in the G0 G1 phase. In a xenograft mouse model using MKN-45 cells, PROTACc-Met degrader-1 demonstrates antitumor activity.
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EGFR-IN-131
T201154
EGFR-IN-131 (compound 3a) is an efficacious EGFR inhibitor capable of crossing the blood-brain barrier, with an IC50 value of 272.9 nM. This compound exhibits anti-proliferative activity, induces cellular apoptosis (apoptosis), and causes cell cycle arrest in the G0 G1 phase. Additionally, EGFR-IN-131 reduces the protein expression of p-EGFR.
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HSP90-IN-33
T201275
HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0 G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.
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Apoptosis inducer 30
T201277
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0 G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.
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PAK4-IN-5
T201422
PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0 G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg kg (oral).
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10-14 weeks
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APOL1-IN-2
T2030302956781-84-1
APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1). It effectively reduces HEK293 cell death induced by APOL1 G2 G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2 G1 G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.
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10-14 weeks
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