g 36

G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM, respectively). G36 has no detectable binding activity to either ERα or ERβ. G36 blocks the activation of PI3K or calcium mobilization triggered by estrogen through GPER and it suppresses ERK activation by estrogen or G-1 but not by EGF. G-36 can be used in combination with GPER-selective agonists, like G-1, to distinguish the roles of GPER from those of ERα and ERβ in complex biological systems.

N36Mut(e,g) is an HIV fusion peptide inhibitor targeting gp41. It functions by disrupting the formation of the homotrimeric coiled coil of the N-terminal helix in the pre-hairpin intermediate, leading to the creation of a heterotrimer.

JG 365 is an HIV protease inhibitor.

Exatecan analog 36, an analog of Exatecan (DX-8951), is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM) [1].

AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the onset of experimental autoimmune encephalomyelitis in rats. encephalomyelitis in rats.

Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).

Cremophor EL is a nonionic surfactant. cremophor EL inhibits cellular metabolism and suppresses UGT1A1-mediated rhodopsin glucuronidation.

PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).

Amino-PEG36-acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG36-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG36-Boc is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands to form PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG36-CH2-Boc is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules. It enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amino-PEG36-CONH-PEG36-acid is a polyethylene glycol (PEG)-based linker featuring amino and carboxylic acid functionalities, utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG36-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG36-alcohol, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Azido-PEG36-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG36-acid, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules. This linker promotes selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Biotin-PEG36-PFP ester is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-NH-PEG36-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1].

Cbz-NH-PEG36-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands vital for PROTAC molecule formation. It enables selective protein degradation by utilizing the cell's ubiquitin-proteasome system.

DSPE-PEG36-DBCO, a PEG-based linker for PROTACs, connects two essential ligands necessary for forming PROTAC molecules, thereby facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

DSPE-PEG36-mal is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-N-amido-PEG36-acid is a polyethylene glycol (PEG)-based linker used in PROTAC synthesis, designed to construct bifunctional molecules that recruit target proteins to an E3 ubiquitin ligase for degradation[1].

m-PEG36-alcohol is a PEG-based linker for PROTACs that joins two essential ligands, crucial for the formation of PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.