fx1

FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).

DFX117 is an orally effective selective inhibitor of PI3Kα and c-Met tyrosine kinase (c-Met). This compound inhibits the PI3K Akt mTOR pathway and suppresses the proliferation of NCI-H1975, NCI-H1993, and HCC827 cells, with IC50 values ranging from 0.02 to 0.08 µM. Additionally, DFX117 induces cell cycle arrest in the G0 G1 phase and triggers apoptosis (apoptosis) in A549 and NCI-H1975 cells. It also exhibits antitumor activity in mice.

cMCoFx1 is an effective and selective FXIIa cyclic peptide inhibitor. It exhibits high binding affinity for FXIIa (KD: 900 pM) and potent inhibitory activity (Ki: 370 pM). cMCoFx1 effectively suppresses the intrinsic coagulation pathway, demonstrates high stability in serum, and shows no cytotoxicity.