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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8767 | PfDHODH-IN-2 | Dehydrogenase , Parasite | |
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m... | |||
T12438 | PfDHODH-IN-1 | Dehydrogenase , Parasite | |
PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity. | |||
T5421 | KDU691 | Parasite , PI4K | |
KDU691 is a PI4K inhibitor. | |||
T9984 | Antimalarial agent 13 | N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine | Parasite |
Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent. | |||
T7167 | Purvalanol B | NG 95 | CDK , Parasite |
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) | |||
T22381 | Antimalarial agent 14 | 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone | Others |
Antimalarial agent 14 (NSC-102533) is a bioactive chemical. | |||
T16269 | Nanaomycin A | DNA Methyltransferase , Dehydrogenase , Parasite | |
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM). | |||
T16697 | Pyronaridine tetraphosphate | Topoisomerase | |
Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum an... | |||
T9591 | YCN47284 | Parasite | |
YCN47284 is an antimalarial compound with an IC50 of 1 μM for P. falciparum. | |||
T14324 | Artemisone | BAY 44-9585,Artemifone | Others , Parasite |
Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV. | |||
T16326 | Cipargamin | KAE609,NITD609 | Parasite |
Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum. | |||
T40417 | Ethylhydrocupreine hydrochloride | Optochin hydrochloride | Antibacterial , Parasite |
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of... | |||
T9858 | 5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole | Parasite | |
Antileishmanial agent-2 is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM. | |||
T10378 | Artelinic acid | Others | |
Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum. | |||
T11030 | DHODH-IN-8 | Dehydrogenase | |
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. | |||
T16125 | MMV390048 | Parasite , PI4K | |
MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal... | |||
T14766 | BPH-715 | Others , Parasite | |
BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells. | |||
T10356 | AQ-13 dihydrochloride | Parasite | |
AQ-13 dihydrochloride is an antimalarial drug. It is effective against drug-resistant strains of Plasmodium falciparum. | |||
T13246 | UCT943 | Parasite , PI4K | |
UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM). | |||
T21022 | Deacylketoconazole | Deacyl ketoconazole | Antifungal |
Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent. Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole. | |||
T11027 | DHODH-IN-4 | Dehydrogenase | |
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity. | |||
T10903 | CWHM-1552 | Parasite | |
CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM. | |||
T0860 | Mefloquine hydrochloride | Mefloquin hydrochloride,Mefloquine HCl | Potassium Channel , SARS-CoV , Reactive Oxygen Species , Parasite , Autophagy |
Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria. | |||
T12909 | SID 26681509 | Cysteine Protease , Parasite | |
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM). | |||
T67694 | ZY-19489 | Parasite | |
ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA. | |||
T74696 | SpdSyn binder-1 | Parasite | |
SpdSyn binder-1 is a weak binding agent that binds to the active site of Plasmodium falciparum spermidine synthase, which is partially inhibitory to malaria and can be used to study malaria. | |||
T5493 | Pyronaridine | Others | |
Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combin... | |||
T11558 | Hexyl gallate | Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate | Antibacterial |
Hexyl gallate (Gallic acid hexyl ester), an alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum (IC50: 0.11 mM). | |||
T9741 | INE963 | Others | |
INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P.... | |||
T17257L | WR99210 hydrochloride(47326-86-3 free base) | WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine | Others |
WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut... | |||
T27214 | DSM421 | DSM 421,DSM-421 | Dehydrogenase |
DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax... | |||
T1491 | Atovaquone | Atavaquone | Others , P450 , Dehydrogenase , Antibiotic , Parasite |
Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. | |||
T3266 | Lumefantrine | Benflumetol,dl-Benflumelol | Others , Parasite , Autophagy |
Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects again... | |||
T0049 | Azlocillin sodium salt | Sodium azlocillin,Azlocillin sodium | Antibacterial , Antibiotic , Parasite |
Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics | |||
T11039 | Didesethyl chloroquine | Bisdesethylchloroquine | Drug Metabolite |
Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine. | |||
Fr13587 | 7-Chloro-4-(piperazin-1-yl)quinoline | ||
7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacological profiles. 7-Chloro-4-(piperazin-1-yl)q... | |||
T4220 | BQR-695 | BQR695,NVP-BQR695 | PI3K , Parasite , PI4K |
BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively. | |||
T15173 | DSM265 | PfSPZ | Dehydrogenase , Parasite |
DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infectio... | |||
T14325 | Arterolane | OZ 277,RBx 11160 | Others |
Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM. | |||
T10902 | CWHM-1008 | Others | |
CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively. | |||
T11331 | FTI 276 TFA | Others | |
FTI 276 TFA is effective against plasmodium falciparum and humans.It is a protein-based nikyltransferase (PFT) inhibitor with an IC50s of 0.9 nM and 0.5 nM, respectively. | |||
T71841 | MMV085203 | ||
MMV08520 is a novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites. | |||
T20910 | Dibemethine | Dibemetina,DBMA,AI3-26795,Dibemethinum | |
Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT). | |||
T71061 | DSM267 | ||
DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor. | |||
T68421 | MMV019662 | ||
MMV019662 is a novel inhibitor of Plasmodium falciparum. | |||
T12084 | MMV008138 | Others | |
MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM). | |||
T36649 | AN3661 | ||
AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains... | |||
T25524 | IDI-3783 | ||
IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). | |||
T25448 | Genz-669178 | ||
Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). | |||
T25815 | Mirincamycin HCl | U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride | |
Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN7103 | 13,21-Dihydroeurycomanone | Pasakbumin C | Anti-infection , Parasite |
13,21-Dihydroeurycomanone (Pasakbumin C) is a natural product isolated from the root of Eurycoma longifolia with antiparasitic activity such as Plasmodium falciparum and Toxoplasma gondii. | |||
T6S0084 | Tuberostemonine | Tuberstemonine | Parasite |
1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction. | |||
TN2027 | Oxysanguinarine | 8-Oxosanguinarine,Hydroxysanguinarine | Parasite |
Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus. | |||
T3933 | Jatrorrhizine | Yatrorizine,neprotin | MAO , 5-HT Receptor , Antibacterial , AChE |
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
T3327 | Artemotil | SM-227,β-Arteether,Beta-Arteether,Arteether,(+)-Arteether | CXCR , CCR , Parasite |
Artemotil (SM-227) is a new, fast-acting antimalarial drug. | |||
T3682 | (-)-Catechin gallate | (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate | Others , COX |
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat... | |||
TN3790 | Dehydroabietinol | Pomiferin A,Dehydroabietyl alcohol | Antifection |
Dehydroabietinol (Pomiferin A) inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). | |||
T0392 | Artemisinin | Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine | HCV Protease , Ferroptosis , Akt , Parasite |
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ... | |||
TN1905 | Magnolioside | Antifection | |
Magnolioside has anti-plasmodial activity, shows notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum. It also shows a moderate antibacterial activity against Staphylococcus aureus CI... | |||
TN1019 | Beta-mangostin | β-Mangostin | Apoptosis , Antibacterial , Parasite |
Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo... | |||
TCS2070 | Homogentisic acid | 2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid | Antioxidant , Endogenous Metabolite |
1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidant... | |||
T35749 | Thymohydroquinone | Thymoquinol | Antioxidant , Reactive Oxygen Species |
Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulate... | |||
T2S2362 | Dehydrocorydaline nitrate | BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy | |
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... | |||
TN4883 | Quinine sulfate dihydrate | Others | |
Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassiu... | |||
TN3466 | Atherosperminine | cAMP , Calcium Channel , AChR , Parasite | |
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t... | |||
T11802 | L-Canaline | Others | |
L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50... | |||
TN4314 | Isonardoperoxide | Antifection | |
Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M). | |||
T11681 | Isochondrodendrine | Isochondrodendrin | Others |
Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. | |||
TN4933 | Sahandol | Antifection | |
Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense. | |||
TN2485 | 1,2-Dihydrotanshinone | 1,2-Dihydrotanshinquinone | Antifection |
1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. | |||
TN4717 | Oplopanone | Antifection | |
Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain. | |||
TN3583 | Canophyllal | Antifection | |
Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs. | |||
TN3563 | Caesalmin B | Antifection | |
Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. | |||
T11509 | Guanfu base H | Atisinium chloride | Others |
Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM). | |||
TN2747 | 2-Acetoxy-3-deacetoxycaesaldekarin E | Antifection | |
2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. | |||
TN1930 | Methylenetanshinquinone | Antifection | |
Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. | |||
TN4202 | (-)-Heraclenol | Antifection | |
(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities. | |||
TN5657 | Goniotriol | ||
Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity a... | |||
TN1442 | Betulinic acid methyl ester | Antifection | |
Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis. | |||
TN4666 | Norcaesalpinin E | Antifection | |
Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM. | |||
TN3987 | Eriodictyol chalcone | Anti-infection , Aromatase | |
Eriodictyol chalcone has anti-plasmodial effects on P. falciparum growth. | |||
T16719 | Radicicol | Monorden | HSP |
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and pr... | |||
T79984 | Chaparrinone | Parasite | |
Chaparrinone, a quassinoid derived from the root of Eurycoma harmandiana, exhibits antimalarial and cytotoxic properties, with IC50 values of 0.037 μg/mL against Plasmodium falciparum and 0.34 μg/mL against P-388 cells [... | |||
T71896 | Brevicompanine B | ||
Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various gen... | |||
TN3124 | 5-Hydroxysophoranone | Antibacterial , Parasite , Antifection | |
5-Hydroxysophoranone is extracted from Erythrina subumbrans stems and exhibits high antiplasmodial activity against Plasmodium falciparum (IC50 = 2.5 μg/mL). | |||
TN2738 | 2,6-Dimethoxy-1-acetonylquinol | Antifection | |
2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line. | |||
TN4716 | Oplodiol | Influenza Virus | |
Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows mode... | |||
T75450 | P-orlandin | ||
P-orlandin, a fungal metabolite, effectively impedes Plasmodium falciparum infection in mosquitoes by preventing FREP1 from binding to gametocytes or ookinetes [1]. | |||
T75568 | Z-Antiepilepsirine | ||
Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1]. | |||
T75676 | Orotidine 5′-monophosphate trisodium | ||
Orotidine 5'-monophosphate trisodium, a pyrimidine nucleotide, is synthesized through the de novo DNA synthesis pathway by various microorganisms, including M. tuberculosis, S. cerevisiae, S. typhimurium, and P. falcipar... | |||
T75447 | Asperaculane B | ||
Asperaculane B, a fungal metabolite, exhibits anti-malarial activity by inhibiting Plasmodium falciparum transmission and its asexual development, with IC50 values of 7.89 µM and 3 µM, respectively. Additionally, it is n... | |||
TN4113 | Garcinone E | Antifection | |
Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent... | |||
T35483 | 19,20-Epoxycytochalasin D | ||
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for... | |||
T35754 | Aszonapyrone A | ||
Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, ... | |||
TN4449 | Longistylin C | Antifection | |
Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vit... | |||
T35758 | Butyrolactone V | ||
Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amaz... | |||
TN5474 | Bonducellin | ||
Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon... | |||
TN4683 | Nyasol | ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt , Antifection | |
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antif... | |||
TN2120 | Quassin | Others , Antifection | |
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. | |||
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Cat No. | Product Name | Species | Expression System |
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TMPY-04180 | PfLDH Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli |
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as... | |||
TMPH-03143 | PFD0110w Protein, Plasmodium falciparum, Recombinant | Plasmodium falciparum | E. coli |
During the asexual blood stage, binds to a sialic acid containing receptor on the surface of the host erythrocyte and thus is involved in merozoite invasion. Binds erythrocytes via a neuraminidase sensitive and trypsin-,... | |||
TMPH-03137 | PFS230 Protein, Plasmodium falciparum, Recombinant | Plasmodium falciparum | E. coli |
Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with erythrocytes. | |||
TMPH-03140 | Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His) | Plasmodium falciparum | E. coli |
During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an ess... | |||
TMPY-04181 | PfHPRT Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli |
pfHPRT Protein, P. falciparum, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 28.6 kDa. Accession number: Q76NM3 | |||
TMPH-03138 | GST Protein, Plasmodium falciparum, Recombinant (His) | Plasmodium falciparum | Yeast |
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin). | |||
TMPH-03141 | Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc) | Plasmodium falciparum | Baculovirus |
During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host... | |||
TMPH-03139 | MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) | Plasmodium falciparum | E. coli |
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. | |||
TMPH-03142 | Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc) | Plasmodium falciparum | E. coli |
During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host... | |||
TMPY-00981 | ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) | Human | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-01142 | ICAM-1/CD54 Protein, Human, Recombinant (His) | Human | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-01349 | ICAM-1/CD54 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-05017 | ICAM-1/CD54 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-06778 | ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480, LEVLFQ) | Human | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-01320 | ICAM-1/CD54 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-00825 | ICAM-1/CD54 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-00239 | ICAM-1/CD54 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-05393 | ICAM-1/CD54 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-06777 | ICAM-1/CD54 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-02017 | ICAM-1/CD54 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPY-06753 | ICAM-1/CD54 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 |
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC... | |||
TMPH-01073 | CD81 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalizati... |