erso

ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.

(S)-ErSO is an inactive dextrorotatory enantiomer of ErSO.

(±)-ErSO is the racemic form of ErSO. ErSO is a selective anticipatory activator of the unfolded protein response (a-UPR).

ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.

(Rac)-ErSO-DFP, a derivative of ErSO-DFP, is a selective small molecule that overactivates ERα+-dependent anticipatory unfolded protein responses. It functions as an Erα biomodulator and demonstrates efficacy against anti-estrogen receptor alpha-positive breast cancer, including resistant tumors.

ErSO-DFP is an expected activator of the unfolded protein response (a-UPR). erSO-DFP improves selectivity for oestrogen receptor alpha+ (ERα+) cancer cells with higher selectivity than ErSO. erSO-DFP has anti-tumour effects and significantly eliminates MCF-7 tumours in a mouse model.

Tocofersolan (TPGS) is a polyethylene glycol derivative of α-tocopherol and synthetic water-soluble version of Tocopherol. Tocofersolan is an oral treatment of vitamin E deficiency due to digestive malabsorption in pediatric patients with congenital chronic cholestasis or hereditary chronic cholestasis.

Tocophersolan, a synthetic polymer and form of vitamin E, can independently form micelles because of its amphiphilic nature, allowing for easy absorption by intestinal epithelial cells even in the absence of bile salts.

Tabersonine (Tabersonin)is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus.

TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

Altersolanol A (Stemphylin; NSC 173943) demonstrates effective antimicrobial properties, inhibiting the growth of Bacillus subtilis and Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) ranging from 25-100 μg/mL. Additionally, it shows no phytotoxic effects on Taxus at a concentration of 4 μg/μL.

Ersodetug is a monoclonal antibody of the Human IgG2κ type that acts against the INSR (insulin receptor). The isotype control product for Ersodetug is Human IgG2kappa, Isotype Control.

Rogersonin E is isolated from Clonostachys rogersoniana, a fungus associated with Ophiocordyceps. This compound can downregulate the expression of the PD-L1 protein in MDA-MB-231 and A549 cells.

11-Hydroxytabersonine has antitumor activety.

Diversoside is a natural product from Aster subspicatus.

The compound retro-inverso TAT-Beclin 1 D-amino acid demonstrates superior activity and resistance to proteolytic degradation compared to the L-amino acid peptide when used in vivo. TAT-Beclin 1 is capable of inducing autophagy in peripheral tissues of adult mice and in the central nervous system of newborn mice.