dopamine

Dopamine receptor agonist

Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor.

Dopamine-PEG-N3 (MW 1000) (Dopamine-PEG-Azide (MW 1000)) is a compound made from dopamine, a PEG segment, and an azide group (-N3). It serves as a crosslinker to connect different materials in the creation of new composite materials, enhancing their properties. This compound is used in click chemistry, containing an azide group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules bearing alkyne groups.

Dopamine-PEG-N3 (MW 400) (Dopamine-PEG-Azide (MW 400)) is a compound composed of dopamine, a PEG segment, and an azide group (-N3). It serves as a crosslinking agent to connect different materials for constructing novel composites, enhancing their properties. As a click chemistry reagent, Dopamine-PEG-N3 (MW 400) contains an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups.

Dopamine-PEG-N3 (MW 3400) (Dopamine-PEG-Azide (MW 3400)) is a compound composed of dopamine, a PEG segment, and an azide group (-N3). This compound serves as a crosslinking agent to connect various materials, facilitating the construction of innovative composite materials and enhancing their properties. Additionally, Dopamine-PEG-N3 (MW 3400) functions as a reagent in click chemistry, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups.

Dopamine-PEG-N3 (MW 5000) (Dopamine-PEG-Azide (MW 5000)) is a compound comprised of dopamine, a PEG segment, and an azide group (-N3). It serves as a crosslinker to connect various materials, forming innovative composites and enhancing material properties. As a click chemistry reagent, it contains an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing alkyne groups.

Dopamine-PEG-N3 (MW 10000) (Dopamine-PEG-Azide (MW 10000)) is a compound comprising dopamine, a PEG segment, and an azide group (-N3). This compound serves as a crosslinking agent to connect various materials for the creation of novel composites, enhancing their properties. It functions as a click chemistry reagent, containing an azide group that participates in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that have alkyne groups.

Dopamine-PEG-N3 (MW 2000) (Dopamine-PEG-Azide (MW 2000)) is a compound consisting of dopamine, a PEG segment, and an azide group (-N3). It serves as a crosslinker to connect various materials, aiding in the creation of novel composites and enhancing material properties. As a click chemistry reagent, it contains an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing an alkyne group.

Dopamine-PEG-N3 (MW 600) (Dopamine-PEG-Azide (MW 600)) is a compound combining dopamine, a PEG (polyethylene glycol) segment, and an azide group (-N3). It serves as a crosslinker to connect diverse materials, facilitating the construction of innovative composites and enhancing material properties. As a click chemistry reagent, Dopamine-PEG-N3 (MW 600) contains an azide group capable of undergoing a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) with molecules containing alkyne groups.

Oxidopamine hydrobromide (6-OHDA hydrobromide) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the pro-inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).

Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is a widely used neurotoxin and an antagonist of the neurotransmitter dopamine. It selectively destroys dopaminergic neurons, promotes COX-2 activation, induces PGE2 synthesis, and stimulates the secretion of the inflammatory cytokine IL-1β. It is commonly used to establish animal models of Parkinson’s disease (PD).

Dopamine D2 Receptor Antagonist-1 functions as a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R), demonstrating sub-millimolar affinity.

3-Methoxy Dopamine-d4 Hydrochloride (3-O-methyl Dopamine-d4 hydrochloride) is a deuterated methoxytyramine hydrochloride.

Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.

ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity.

MPTP hydrochloride is a dopamine neurotoxin and the precursor of MPP⁺. It can induce apoptosis and has the ability to cross the blood-brain barrier. MPTP hydrochloride is toxic to dopaminergic neurons and is commonly used for the construction of Parkinson's disease animal models.

Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.

Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depression and anxiety.

Benzamide Derivative 1 Benzamide derivative with gastrokinetic activity.Benzamide Derivative 1 can be used in the study of gastrointestinal diseases.

SPD-473 citrate (BTS 74398 citrate) is a dopamine reuptake inhibitor, a norepinephrine transporter protein (NET) inhibitor, and a 5-hydroxytryptamine reuptake inhibitor, and is used in the study of neurological disorders and endocrine and metabolic diseases.

6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.

Roxindole (EMD 49980) is a selective dopamine autoreceptor and 5-HT1A dual agonist and inhibitor of 5-hydroxytryptamine (5-HT) uptake with antipsychotic and antidepressant activity.Roxindole can be used to study Parkinson's and neurodivergence.

PF-184298 is a serotonin and norepinephrine monoamine reuptake inhibitor (SNRI) that inhibits dopamine reuptake.