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Results for "

craf-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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RAF1 Protein, Human, Recombinant (His)
Raf-1, RAF1, RAF proto-oncogene serine threonine-protein kinase, RAF, Proto-oncogene c-RAF (cRaf)
TMPH-01995
Expression system: E. coli
Length: 1-648, Full Length
Activity: Not Tested
  • Inquiry Price
20 days
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Buffer-exchangeable
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RAF1 Protein, Human, Recombinant (His & GST)
Raf-1 proto-oncogene, serine threonine kinase, Raf-1, NS5, c-Raf, CRAF, CMD1NN
TMPY-05095
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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7-10 days
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