control

Necrostatin-1 (Nec-1) (inactive control), an inactive analog of Necrostatin-1, functions as a potent inhibitor of necroptosis [1].

Human IgG1 lambda2, Isotype Control is a human monoclonal antibody serving as an isotype control for human IgG1κ antibodies, used to eliminate nonspecific signals in experiments.

Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins.In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin

SLLK, Control Peptide for TSP1 Inhibitor acetate is a control peptide for LSKL.

The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.

MPSDcontrol peptide (MARCKS-ED control peptide) TFA serves as the control peptide for MPSD. MPSD (MARCKS-ED) is a 25-amino acid peptide derived from the effector domain sequence of MARCKS, a myristoylated alanine-rich C kinase substrate, which is an intracellular membrane protein.

MPSDcontrol peptide (MARCKS-ED control peptide) serves as the counterpart for the MPSD peptide. MPSD (MARCKS-ED) is a 25-amino acid residue peptide derived from the effector domain sequence of the endoplasmic reticulum protein MARCKS. It can detect membrane curvature and identify phosphatidylserine, functioning as a biological probe for examining membrane morphology and lipid composition.

Fibronectin Active Fragment Control acetate is an active fragment of fibronectin which is a glycoprotein.

SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β/MKK7 (growth arrest and DNA damage-inducible β/mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 μM, respectively.

ERK Inhibitor II (Negative control) effectively blocks extracellular signal-regulated kinase (ERK) activity and interferes with insulin receptor activation, serving as a valuable tool in diabetes research.

SLLK is a control peptide for LSKL.

Compstatin control peptide acetate is a negative control of Compstatin. Compstatin is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.

Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.

Trometamol hydrochloride (TRIS hydrochloride) (Tromethamine hydrochloride) is a biologically inert amino alcohol with low toxicity. Trometamol hydrochloride buffers carbon dioxide and acids in vitro and in vivo. Trometamol hydrochloride is an effective amine compound for pH control in the physiological range.

TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.

inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503

PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.

BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705, a GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM, used in acute myeloid leukemia [AML] studies.

KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.

GAL-021 an intravenous BKCa-channel blocker.

Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspecified site on tubulin and suppresses microtubule assembly dynamic. This results in cell cycle arrest at the G2/M phase and an induction of apoptosis.

GSK8573 is an inactive control compound for GSK2801, with binding activity to BRD9 (Kd of 1.04 μM).

ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.