circadian rhythms

(E Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.

1A-116 is a specific inhibitor of Rac1 .

GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice.

KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP PKA CREB pathway.

FT709 is a selective and potent inhibitor of USP9X (IC50: 82 nM), a protein associated with centrosome function, EGF receptor degradation, chromosome alignment during mitosis, chemosensitization, and circadian rhythms.

PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta epsilon (CK1δ ε) that modulates circadian rhythms in mice.

VU661, a redox-active phenazine carboxamide, modulates circadian rhythms by inducing period lengthening.

KL201, a circadian clock modulator, is an isoform-selective cryptochrome 1 (CRY1) stabilizer that lengthens the period of circadian rhythms in cells and tissues [1].