Search Result

Search Results for " circadian "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T22891	KL001	KL 001,KL-001	Others
	KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced glu...		Others
T14004	1A-116		Rho
	1A-116 is a specific inhibitor of Rac1 .		Rho
T9608	KL201		Others
	KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1].		Others
TP1264	Prolylleucine	((Benzyloxy)carbonyl)-L-prolyl-D-leucine	Others
	Prolylleucine (((Benzyloxy)carbonyl)-L-prolyl-D-leucine) is a dipeptide containing branched-chain amino acids.		Others
T9356	(E/Z)-GO289		Casein Kinase
	(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function...		Casein Kinase
T3495	Tasimelteon	VEC-162,BMS-214778	Melatonin Receptor , MT Receptor
	Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.		Melatonin Receptor , MT Receptor
T73573	CLK8		Others
	CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-...		Others
T27931	LY2033298	LY 2033298,LY-2033298	AChR
	LY2033298, a positive allosteric modulator of muscarine M4 receptor, enhances the inhibitory effect of oximoline on light-induced phase shift in circadian activity in hamsters and can be used in neurosystem-related disea...		AChR
T32401	KL044	KL 044,KL-044	Others
	KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway.		Others
T3685	SR9009	Stenabolic,REV-ERB Agonist II	Autophagy
	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during...		Autophagy
T27430	GR 196429	GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429
	GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice.
T70812	PF-05236216 hydrochloride
	PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice.
T82587	Delta (Phospho) Sleep Inducing Peptide	DSIP-P
	Delta (Phospho) Sleep Inducing Peptide (DSIP-P), a peptide that promotes sustained sleep, elicits alterations in circadian locomotor activity in rats [1] [2] [3].
T63375	FT709
	FT709 is a selective and potent inhibitor of USP9X (IC50: 82 nM). Among others, USP9X is associated with centrosome function, EGF receptor degradation, chromosome alignment during mitosis, chemosensitization and circadia...
T17095	TIK-301	PD-6735,LY-156735	5-HT Receptor
	TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor an...		5-HT Receptor
T80849	VU661
	VU661, a redox-active phenazine carboxamide, modulates circadian rhythms by inducing period lengthening.
TP1980	Neuromedin S(rat)	Neuromedin S (rat)
	Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent en...
T38433	KS15
	KS15 is a chemical compound that acts as an inhibitor on the interactions between cryptochromes, specifically CRY1 and CRY2, and the CLOCK: BMAL1 heterodimer. This compound, with an EC50 value of 4.9 μM, hinders the feed...
TP2194	Neuropeptide Y (scrambled)		Others
	Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiologi...		Others
T35993	Epitalon (acetate)
	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.1 Epitalo...

Compounds

KL001

T22891

Synonym: KL 001,KL-001

Synonym: ((Benzyloxy)carbonyl)-L-prolyl-D-leucine

Target: Casein Kinase

Tasimelteon

T3495

Synonym: VEC-162,BMS-214778

Target: Melatonin Receptor, MT Receptor

Synonym: LY 2033298,LY-2033298

Target: AChR

KL044

T32401

Synonym: KL 044,KL-044

Target: Others

SR9009

T3685

Synonym: Stenabolic,REV-ERB Agonist II

Target: Autophagy

GR 196429

T27430

Synonym: GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429

Target:

PF-05236216 hydrochloride

T70812

Synonym:

Target:

Delta (Phospho) Sleep Inducing Peptide

Synonym: PD-6735,LY-156735

Target: 5-HT Receptor

Synonym: Neuromedin S (rat)

Neuropeptide Y (scrambled)

Cat No.	Product Name	Targets
T71896	Brevicompanine B
	Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various gen...
TN1812	Jujuboside B1	5-HT Receptor
	Jujubosides have hypnotic effect on normal rats, may be influenced by circadian rhythm and the serotonergic system may involve in the hypnotic effect of jujubosides, jujubosides may be good source of lead compounds for n...	5-HT Receptor

Natural Products

Target: 5-HT Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00009	OGT Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc...
TMPH-01054	CSNK1E Protein, Human, Recombinant (His)	Human	E. coli
	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL...
TMPH-00079	Beta-amylase 3, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	E. coli
	Beta-amylase activity. No alpha-amylase activity. Involved in cold resistance. Mediates the accumulation of maltose upon freezing stress, thus contributing to the protection of the photosynthetic electron transport chain...
TMPH-01241	TOP1 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via tran...
TMPH-03711	PPAR gamma Protein, Xenopus laevis, Recombinant (His)	Xenopus laevis	E. coli
	Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcript...
TMPH-01243	ID1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcription...
TMPY-01120	VPAC2 Protein, Human, Recombinant (mFc)	Human	HEK293
	VIP and PACAP receptor 2, or VIPR2 encodes the VPAC2 receptor, which binds both VIP and PACAP. VPAC2 is expressed throughout the central nervous system and the periphery. Mutations in the VIPR2 homolog in the mouse cause...
TMPH-01734	METTL3 Protein, Human, Recombinant (His)	Human	E. coli
	The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of emb...
TMPH-01900	DDX5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop r...
TMPY-00286	Neuropeptide Y Protein, Human, Recombinant (hFc)	Human	HEK293
	NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress ...
TMPH-02810	NAMPT Protein, Mouse, Recombinant (His)	Mouse	Yeast
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPH-03761	NAMPT Protein, Mouse, Recombinant (HA & His)	Mouse	E. coli
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPH-01791	RORA Protein, Human, Recombinant (His)	Human	E. coli
	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular d...
TMPJ-01112	PRKG1 Protein, Human, Recombinant (His)	Human	Human Cells
	cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro...
TMPH-02827	PPAR gamma Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the tra...
TMPH-03760	NAMPT Protein, Mouse, Recombinant	Mouse	E. coli
	The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low lev...
TMPH-01792	RORC Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunit...
TMPH-01794	NR2F6 Protein, Human, Recombinant (His & Myc)	Human	HEK293
	Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are a...
TMPH-01795	NR2F6 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are a...
TMPH-02179	TARDBP Protein, Human, Recombinant (His)	Human	Yeast
	RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized withi...
TMPH-02178	TARDBP Protein, Human, Recombinant	Human	E. coli
	RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized withi...
TMPH-03274	ATF-4 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, an...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02855	PML Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and vi...
TMPH-01255	DNM1L Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondri...
TMPH-01075	P53 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02286	USP7 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M...