Search Result

Search Results for " chondrocytes "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1748	Kartogenin	KGN	TGF-beta/Smad
	Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.		TGF-beta/Smad
T9138	Indirubin-3′-oxime	Indirubin-3'-monoxime	GSK-3 , CDK , JNK
	Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.		GSK-3 , CDK , JNK
TQ0228	Derazantinib	ARQ-087	FGFR
	Derazantinib (ARQ-087) (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/4.5 nM).		FGFR
T40795	BNTA		Reactive Oxygen Species
	BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxid...		Reactive Oxygen Species
T76277L	Vosoritide acetate
	Vosoritide acetate (BMN 111) is a natriuretic peptide receptor 2 (NPR2) agonist that promotes bone growth by influencing the proliferation and differentiation of chondrocytes [1].
T39531	RAD16-I hydrochloride	RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes....
T71525	AB05831
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis...
T10997	Derazantinib Racemate	ARQ-087 Racemate	Others
	Derazantinib Racemate (ARQ-087 Racemate) is the racemate of Derazantinib. Derazantinib is an orally bioavailable, ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocy...		Others
T83733	TIP39 (human, bovine) TFA	Tuberoinfundibular Peptide of 39 Residues
	TIP39, a neuropeptide and an agonist for the parathyroid hormone receptor type 2 (PTH2R), effectively increases cAMP levels in COS-7 cells featuring recombinant PTH2R from humans or rats (EC50s = 0.5 and 0.8 nM, respecti...

Compounds

Kartogenin

T1748

Synonym: KGN

Target: TGF-beta/Smad

Indirubin-3′-oxime

T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

Target: Reactive Oxygen Species

RAD16-I hydrochloride

T39531

Synonym: RAD16-I hydrochloride

Derazantinib Racemate

T10997

Synonym: ARQ-087 Racemate

Target: Others

TIP39 (human, bovine) TFA

T83733

Synonym: Tuberoinfundibular Peptide of 39 Residues

Target:

Cat No.	Product Name	Synonyms	Targets
T2795	Amygdalin	Laetrile	Others
	Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce...		Others
T6S1579	Monotropein	Monotropeine	Others
	1. Monotropein (Monotropeine) has antinociceptive action. 2. Monotropein has anti-apoptosis and anti-catabolic activity in chondrocytes. 3. Monotropein has anti-inflammatory action by inhibition of the expressions of inf...		Others
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2

Natural Products

Synonym: Monotropeine

Target: Apoptosis, Others, Nrf2

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00249	TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated	Human	Human Cells
	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-...
TMPY-00203	LOXL2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 ...
TMPY-01384	Endoglin/CD105 Protein, Human, Recombinant (His)	Human	HEK293
	Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD...
TMPY-01357	S100A9 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPH-02568	CTGF/CCN2 Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types ...
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His)	Human	HEK293
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, follo...
TMPH-01069	CTGF/CCN2 Protein, Human, Recombinant (His)	Human	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types ...
TMPJ-01245	UCMA Protein, Human, Recombinant	Human	E. coli
	C10orf49 is a secreted protein which encoded by the UCMA gene. It is a member of the UCMA family. C10orf49 is predominantly expressed in resting chondrocytes. It may be involved in the negative control of osteogenic diff...
TMPK-00685	CYTL1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Cytokine-like protein 1 (Cytl1), also named Protein C17 or C4orf4 is located on human chromosome 4p15-p16 and encodes a polypeptide of 126 amino acid residues that displays characteristics of a secretory protein. Cytl1 i...
TMPY-00044	CYTL1 Protein, Human, Recombinant (mFc)	Human	HEK293
	Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known protein. Cytokine-like 1 (CYTL1) is a novel potential cytokine that was first ...
TMPK-00019	B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc)	Human	HEK293
	To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly high...
TMPK-00848	BSPII Protein, Human, Recombinant (His)	Human	HEK293
	IBSP (Integrin Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include Fibrous Dysplasia and Chondromalacia. Among its related pathways are Degradation of the extracellular matrix and Cytosk...
TMPK-00498	BSPII Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	IBSP (Integrin Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include Fibrous Dysplasia and Chondromalacia. Among its related pathways are Degradation of the extracellular matrix and Cytosk...
TMPY-01860	Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)	Human	HEK293
	COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early o...
TMPY-03384	CALM2 Protein, Human, Recombinant (His)	Human	E. coli
	Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centro...
TMPJ-01119	GPNMB Protein, Human, Recombinant (His)	Human	Human Cells
	Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one...
TMPY-00572	PRELP Protein, Human, Recombinant	Human	HEK293
	PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N...
TMPY-00571	PRELP Protein, Human, Recombinant (mFc)	Human	HEK293
	PRELP (proline/arginine-rich end leucine-rich repeat protein) is a member of the leucine-rich repeat (LRR) family of extracellular matrix proteins in connective tissue. In contrast with other members of the family, the N...
TMPY-00564	MCP-4 Protein, Human, Recombinant (His)	Human	Yeast
	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family ...
TMPJ-01200	IMPA3 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	IMPAD1 protein (IMPA3, gPAPP or IMPase 3) belongs to the inositol monophosphatase family. It is found in Purkinje cells, brain stem, lung and chondrocytes. Mouse IMPAD1 gene encodes a type II transmembrane Golgi-embedded...
TMPJ-00141	4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	Human Cells
	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I ...
TMPY-01339	S100A6 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-00912	S100A6 Protein, Human, Recombinant	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPJ-00142	4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Human Cells
	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I ...
TMPY-01094	S100A6 Protein, Mouse, Recombinant	Mouse	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01911	PLA2G1B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	phospholipase A2, also known as Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2, PLA2 and PLA2G1B, is a secreted protein that belongs to the phospholipase A2 family. Phospholipase A2 / PLA2G1B catalyzes...
TMPY-01689	PLA2G1B Protein, Human, Recombinant (His)	Human	HEK293
	phospholipase A2, also known as Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2, PLA2 and PLA2G1B, is a secreted protein that belongs to the phospholipase A2 family. Phospholipase A2 / PLA2G1B catalyzes...
TMPJ-01137	MIA Protein, Human, Recombinant (His)	Human	E. coli
	Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed...
TMPY-01879	S100A14 Protein, Human, Recombinant (His)	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-00783	Endoglin/CD105 Protein, Human, Recombinant (hFc)	Human	HEK293
	Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD...
TMPY-01931	S100A5 Protein, Human, Recombinant (His)	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-02463	S100A5 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01615	Endoglin/CD105 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD...
TMPY-02387	NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST)	Human	E. coli
	RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it fac...
TMPY-01476	S100A13 Protein, Human, Recombinant	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01466	S100A12 Protein, Human, Recombinant	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-03699	S100A13 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-00433	CXCL1 Protein, Mouse, Recombinant	Mouse	E. coli
	The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimu...
TMPY-00008	CXCL1 Protein, Rat, Recombinant	Rat	E. coli
	The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimu...
TMPY-02868	CXCL1 Protein, Human, Recombinant	Human	E. coli
	The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimu...
TMPY-02180	CXCL1 Protein, Human, Recombinant (His & NusA)	Human	E. coli
	The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimu...
TMPY-02026	CXCL1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimu...
TMPY-02821	S100A9 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01330	S100A9 Protein, Human, Recombinant	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-01926	S100A10 Protein, Human, Recombinant (His)	Human	E. coli
	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...