carbapenem

Meropenem (SM 7338) is a broad-spectrum carbapenem antibiotic administered intravenously for severe bacterial infections caused by sensitive agents. It commonly causes mild, transient aminotransferase elevations and can rarely lead to clinically apparent cholestatic liver injury.

Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.

Ceftolozane sulfate (FR-264205) is a cephalosporin antibiotic with broad-spectrum antimicrobial activity, inhibits P. aeruginosa PAO1, inhibits Pseudomonas aeruginosa, and is used in the study of pneumonia.

Vaborbactam ammonium salt is a β-lactamase inhibitor that restores carbapenem activity against KPC-producing strains and is often used in conjunction with other drugs to study fungal infections.

Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity.

Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.

Imipenem (MK0787) is a thienomycin derivative that belongs to the class of antibiotics with antibacterial activity and partial inhibition against gram-positive and gram-negative bacteria. Imipenem can be used to study carbapenem non-susceptible infections and Pseudomonas aeruginosa biofilm infections.

Tebipenem is an orally available carbapenem antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria.

Meropenem (SM 7338) sodium is a broad-spectrum carbapenem antibiotic that exhibits activity against both susceptible and resistant strains of Neisseria gonorrhoeae (MIC values of 0.02-0.06 mg mL), Haemophilus influenzae (MIC values of 0.03-0.12 mg mL), and Moraxella catarrhalis (MIC values of 0.015-0.12 mg mL).

Ertapenem is a parenteral carbapenem. It has a broad spectrum of antimicrobial activity. It is highly resistant to inactivation by a wide variety of beta-lactamases.

Benapenem is a carbapenem (β-lactam) compound known for its broad-spectrum antibacterial activity. It is currently under clinical evaluation as an intravenous treatment option for urinary tract infections.

LYS228 (also known as Ancremonam) is a potent antibiotic effective against carbapenem-resistant Enterobacteriaceae bacteria (MIC90 = 2 uM mL). It demonstrates strong antibacterial activity against CRE isolates even in the presence of all classes of β-lactamases.

KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2, with an IC50 value of 8.3 nM. KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems, leading to significant bacterial resistance to carbapenem antibiotics.

Panipenem is a carbapenem antibiotic used in combination with betamipron.

Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

DA 1131 is a new carbapenem antibiotic. It undergoes renal metabolism by renal dehydropeptidase I.

LYS228 is a potent antibiotics against Carbapenem-Resistant Enterobacteriaceae (MIC90 = 2 uM mL). LYS228 is potent in the presence of all classes of beta-lactamases.

Cp-5484 is a new kind of Quaternary carbapenem with strong anti MRSA activity and low acute toxicity.

CS 834, a novel oral carbapenem antibiotic, is an ester prodrug of the active metabolite R-95867.

LK 157 is a tricyclic carbapenem with potent activity against class A and class C beta-lactamases.

Razupenem ( SMP-601, PTZ601) is a broad-spectrum injectable antibiotic derived from the carbapenem subgroup of β-lactam antibiotics. It has been developed as an alternative drug against bacteria that have developed antibiotic resistance to commonly used a

N-3-oxo-pentanoyl-L-Homoserine lactone is a chain-shortened derivative of the bacterial quorum sensing signaling molecule N-3-oxo-octanoyl-L-homoserine lactone .1It inhibits binding of the autoinducer N-3-oxo-hexanoyl homoserine lactone toE. colicontaining the transcription factor LuxR when used at a concentration of 230 nM.2It acts as an autoinducer to activate theV. fischeriluminescence system inE. coliwhen used at concentrations ranging from 20 to 200 nM. 1.Chhabra, S.R., Stead, P., Bainton, N.J., et al.Autoregulation of carbapenem biosynthesis in Erwinia carotovora by analogues of N-(3-oxohexanoyl)-L-homoserine lactoneJ. Antibiot. (Tokyo)46(3)441-454(1993) 2.Schaefer, A.L., Hanzelka, B.L., Eberhard, A., et al.Quorum sensing in Vibrio fischeri: Probing autoinducer-LuxR interactions with autoinducer analogsJ. Bacteriol.178(10)2897-2901(1996)

Acetyl-L-homoserine lactone belongs to the family of N-acylated homoserine lactones (HSLs) and has an acyl chain length of two carbons. HSLs perform a role in quorum sensing; however, unlike other HSLs, acetyl-L-homoserine lactone does not elicit a response in bacteria. In an assay of carbapenem antibiotic biosynthesis, acetyl-L-homoserine lactone does not induce a response in E. carotovora. In a fluorescence assay using E. coli containing a reporter plasmid of GFP expression in response to exogenous HSLs, acetyl-L-homoserine does not elicit GFP production.

TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks.