bilayer

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid utilized in liposomes for the study of lipid monolayers and bilayers.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.

C8 PEG-Ceramide, a lipid product, possesses the capability to synthesize lipid bilayer carriers, making it applicable for drug delivery [1] [2].

DSPE-MAL, a thiol-reactive phospholipid compound, comprises two saturated fatty acids and possesses the ability to self-assemble in water, forming a lipid bilayer. It is utilized in the preparation of liposomes as a nanocarrier agent [1].

Ionizable Lipid-1 (compound II-10), with a pKa of 6.16, is an ionizable lipid capable of forming lipid nanoparticles (LNP) with a bilayer structure [1].

1O14 is an ionizable lipid. Its ability to form unstable non-bilayer structures at acidic pH is crucial for endosomal escape and RNA cytosolic delivery. 1O14 is applicable in the preparation of liposomes.

IAJD93 is an ionizable lipid. Its ability to form unstable non-bilayer structures at acidic pH is crucial for endosomal escape and RNA delivery into the cytosol. IAJD93 can be utilized in the preparation of liposomes.

IAJD249 is an ionizable lipid. This type of lipid is crucial for endosomal escape and the delivery of RNA into the cytosol, due to its ability to form unstable non-bilayer structures at acidic pH. IAJD249 is also utilized in the preparation of liposomes.

Al-28 is an ionizable lipid that plays a crucial role in endosomal escape and RNA cytosol delivery by forming unstable non-bilayer structures at acidic pH. This compound is utilized in the preparation of liposomes.

L16 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is crucial for endosomal escape and RNA cytosolic delivery. L16 can be utilized in liposome preparation.

306Oi9-cis2 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is crucial for endosomal escape and RNA cytosolic delivery. 306Oi9-cis2 is utilized in the preparation of liposomes.

RM 137-15 is an ionizable lipid. Its ability to form unstable non-bilayer structures under acidic pH is crucial for endosomal escape and RNA cytosol delivery. RM 137-15 is utilized in the preparation of liposomes.

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid known for stabilizing membrane bilayer structures and enhancing the activity of compound delivery mediated by liposomes. This compound is extensively utilized in biomedical applications to improve the efficiency of compound delivery. Additionally, 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can optimize intracellular release and distribution of compounds.

16:0-12 Doxyl PC (1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine) functions as a fluorescence quencher, with the nitroxide group situated downstream on the sn-2 chain. It exhibits enhanced fluorescence quenching for fluorophores embedded within the bilayer hydrocarbons.

DL-α-Phosphatidylcholine, distearoyl is a synthetic form of phosphatidylcholine, that spontaneously forms bilayer membranes in aqueous environments. It is a vital component of biological membranes and supports cellular structural integrity. Additionally, DL-α-Phosphatidylcholine, distearoyl plays a crucial role in preparing compound delivery systems, enhancing solubility and biocompatibility of compounds.

C8 PEG5000 Ceramide is a lipid product utilized in the synthesis of lipid bilayer carriers for drug delivery.

Ionizable lipid-1 (compound II-10) is a lipid with an ionizable characteristic (pKa=6.16) that is utilized in the creation of lipid nanoparticles (LNP) with a bilayer structure.

DSPE-PEG-SH (MW 1000) is an amphiphilic PEG polymer that forms a lipid bilayer in aqueous solutions. This polymer can encapsulate active molecules and is applicable in drug delivery systems, such as mRNA vaccines.

DSPE-PEG-SPDP, MW 5000, is an amphiphilic polymer (PEG) capable of forming lipid bilayers in aqueous solutions. It is suitable for encapsulating therapeutic agents. The core can encapsulate hydrophilic substances like proteins peptides and mRNA DNA siRNA, while the lipid bilayer can dissolve hydrophobic drugs such as doxorubicin and curcumin. The SPDP moiety can react with thiol molecules to form disulfide bonds. Reagent grade, for research use only.

18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound utilized in forming stable microcapsule responsive layers, which can be further assembled into bilayer microcapsules. For instance, a responsive layer can be prepared using 18-Crown-6-ether and coated with a K+ stabilized G-quadruplex crosslinked hydrogel layer. In the presence of Mg2+ ions, 18-Crown-6-ether and K+ ions can respectively dissociate and lock with the G-quadruplex crosslinked layer, achieving switchable controlled release of the payload.

Benzo-18-crown-6-ether (B18C6) is an organic compound used to create stable microcapsule responsive layers, which can be assembled into bilayer microcapsules. For instance, 18-Crown-6-ether is employed to prepare a responsive layer and then coated with a K+-stabilized G-quadruplex cross-linked hydrogel layer. When Mg2+ ions are present, 18-Crown-6-ether and K+ ions enable dissociation and locking with the G-quadruplex cross-linked layer, allowing for switchable controlled release of the load.