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Search Result

Search Results for " autophagosome "

Targets

P2X Receptor 5-HT Receptor Autophagy

13

Compounds

2

Natural Products

4

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T8946 Indophagolin P2X Receptor , 5-HT Receptor , Autophagy
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
T8081 LC3-mHTT-IN-AN1 Others , Autophagy , ATTECs
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner...
T11142 EACC Autophagy
EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a...
T4079 LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286 PI3K
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...
T27084 Crisdesalazine AAD2004,AAD 2004,AAD-2004 Prostaglandin Receptor
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre...
T5181 CA-5f Apoptosis , Autophagy
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
T16104 ML-9 Myosin , Akt
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction ...
T22034 ARP 101
ARP101, a potent and selective matrix metalloproteinase-2 (MMP-2) inhibitor, effectively promotes autophagy-associated cell death in cancer cells by inducing autophagosome formation and converting LC3I into LC3II [1].
T73550 CUR5g
CUR5g, a potent autophagy inhibitor, selectively prevents autophagosome degradation in cancer cells by hindering the fusion of autophagosomes with lysosomes. It disrupts the recruitment of STX17 to autophagosomes through...
T16103 ML-9 Free Base Others
ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal ...
T83945 XIE62-1004
XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagoso...
T76506 Coibamide A
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, exhibits potent antiproliferative activity alongside inducing autophagosome accumulation through an mTOR-independent mechanism and triggering apoptosis. Additio...
T35807 C18 dihydro Ceramide (d18:0/18:0) C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycer...
Cat No. Product Name Synonyms Targets
T5070 LC3-mHTT-IN-AN2 5,7-Dihydroxy-4-phenylcoumarin Antibacterial , Autophagy , ATTECs
LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.
T4S1102 Liensinine diperchlorate Liensinine-Perchlorate Mitophagy , Others , Autophagy
Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...

Natural Products

LC3-mHTT-IN-AN2
T5070
Synonym: 5,7-Dihydroxy-4-phenylcoumarin
Target: Antibacterial, Autophagy, ATTECs
Liensinine diperchlorate
T4S1102
Synonym: Liensinine-Perchlorate
Target: Mitophagy, Others, Autophagy

Recombinant Proteins

Species：
Human (4)
Expression System：
E. coli (4)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
C-6His,N-T7 tag (1)
None (1)
Cat No. Product Name Species Expression System
TMPH-01003 ATG14 Protein, Human, Recombinant (His & Myc) Human E. coli
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidyletha...
TMPJ-01329 ATG5 Protein, Human, Recombinant Human E. coli
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic ce...
TMPJ-01354 ATG3 Protein, Human, Recombinant Human E. coli
Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its ...
TMPH-02282 Ubiquilin-1 Protein, Human, Recombinant (His & Myc) Human E. coli
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
Cat No. Product Name
L3200 Autophagy Compound Library

1248 compounds
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs;

Libraries

Autophagy Compound Library
L3200
Compounds: 1248
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