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Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

Search Result

Search Results for " autoimmune "

Targets

EBI2/GPR183

278

Compounds

12

Natural Products

327

Recombinant Proteins

3

Libraries

Cat No. Product Name Synonyms Targets
T7156 NIBR189 EBI2/GPR183
NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively)
T8527 CPYPP Others
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 µM). CPY...
T9060 STM2457 Apoptosis , Others
STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies.
T8697 ZAP-180013 Tyrosine Kinases , Tyrosinase
ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
TP2315 Glatiramer Acetate Others
Glatiramer acetate (GA) is a synthetic amino acid copolymer that is approved for treatment of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS).
T10722 CD80-IN-3 Bombesin Receptor
CD80-IN-3 is a potent CD80 inhibitor and inhibits CD80/CD28 interaction (Kd: 125 nM; EC50: 630 nM).
T28169 NIBR-0213 NIBR 0213 LPL Receptor
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
T38332 Complement factor D-IN-2 Complement System
Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.
T2302 CNX-774 CNX 774 BTK
CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
T9921 Infliximab TNF
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.
T24984 5J-4 Calcium Channel
5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.
T7503 Upadacitinib ABT-494 JAK
Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.
T4316 ML365 Potassium Channel
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
T9192 BIIB068 BTK
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.
T7879 TASP0415914 Akt , PI3K
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
T13951 UCB-9260 TNF
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
T1814 ICILIN AG-3-5 TRP/TRPV Channel
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
T5310 TR-14035 MDK-1191 Integrin
TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
T12079 ML604440 Proteasome
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
T22102 ML-178 CYM50179 Others
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.
T22398 Phenidone 1-phenyl-3-pyrazolidinone Lipoxygenase , COX
Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg...
T8692 (Rac)-Benpyrine TNF
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
T6761 Ossirene AS101 IL Receptor , Caspase , Interleukin
Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
T15795 Luzindole N-0774 Melatonin Receptor , MT Receptor
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...
T4031 S1p receptor agonist 1 S1p-receptor-agonist-1 S1P Receptor , LPL Receptor
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
T7188 Piclidenoson CF-101,IB-MECA Apoptosis , Adenosine Receptor
Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.
T10549 Bisindolylmaleimide VIII acetate Ro 31-7549 acetate,Bis VIII acetate Apoptosis , PKC
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, resp...
T60012 HS-243 IRAK , MAPK , CDK
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
T0137 Mirtazapine 6-Azamianserin,Org3770 Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h...
T12311 Tirabrutinib hydrochloride ONO-4059 (hydrochloride),GS-4059 (hydrochloride) BTK
Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) is a selective and novelBTK with IC50 2.2 nm inhibitor.
T9137 SN-011 [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901 STING
SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
T6104 Cerdulatinib hydrochloride Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19...
T38078 TLR7/8-IN-1 TLR7/8-IN-1 TLR
TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].
T78607 JAK-STAT-IN-1 JAK , STAT
JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.
T62858 HGPR91 antagonist 3 GPR
hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be...
T26636 Antifolate C2 AGF 154,AGF154,AGF-154 Others
Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases.
T39654 Afimetoran BMS-986256 TLR
Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.
T30077L Anisperimus HCl LF 150195 HCl,Anisperimus HCl（170368-04-4 Free base） Others
Anisperimus HCl (LF 150195 HCl) is a small molecule immunizing agent for the study of autoimmune diseases.
T12422 PF-04957325 PDE
PF-04957325 is a potent and selective inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A and 0.3 nM for PDE8B.PF-04957325 can be used to study autoimmune encephalomyelitis.
T4644 Tapinarof GSK2894512,Benvitimod,WBI 1001 AhR , Aryl Hydrocarbon Receptor
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
T12753 RORγt Inverse agonist 6 ROR
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
T10715 CCR6 inhibitor 1 CCR
CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor ...
T60850 MIF-IN-2 Others
MIF-IN-2 is a heterocyclic macrophage migration inhibitory factor (MIF) inhibitor with anticancer activity for the study of cancer and autoimmune disorders.CAS 번호13460-73-86-5
T21694 (R)-Lisofylline (R)-Lisophylline STAT
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat...
T80678 (S)-AK-242 (-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242 Others
(S)-AK-242 ((S)-Resatorvid) is a cytokine inhibitor used in the treatment of heart disease, autoimmune disease, and inflammatory disease.
T6749 A-1331852 BCL
A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.
T60542 BTK-IN-16 BTK
BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.
T38723 β-Aminoarteether β-Aminoarteether,SM934 free base Others
β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.
T73695 Canakinumab ACZ 885,Ilaris IL Receptor
Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab...
T10009 JAK3-IN-7 JAK
JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...

Compounds

NIBR189
T7156
Synonym:
Target: EBI2/GPR183
CPYPP
T8527
Synonym:
Target: Others
STM2457
T9060
Synonym:
Target: Apoptosis, Others
ZAP-180013
T8697
Synonym:
Target: Tyrosine Kinases, Tyrosinase
glatiramer Acetate
TP2315
Synonym:
Target: Others
CD80-IN-3
T10722
Synonym:
Target: Bombesin Receptor
NIBR-0213
T28169
Synonym: NIBR 0213
Target: LPL Receptor
Complement factor D-IN-2
T38332
Synonym:
Target: Complement System
CNX-774
T2302
Synonym: CNX 774
Target: BTK
Infliximab
T9921
Synonym:
Target: TNF
5J-4
T24984
Synonym:
Target: Calcium Channel
Upadacitinib
T7503
Synonym: ABT-494
Target: JAK
ML365
T4316
Synonym:
Target: Potassium Channel
BIIB068
T9192
Synonym:
Target: BTK
TASP0415914
T7879
Synonym:
Target: Akt, PI3K
UCB-9260
T13951
Synonym:
Target: TNF
ICILIN
T1814
Synonym: AG-3-5
Target: TRP/TRPV Channel
TR-14035
T5310
Synonym: MDK-1191
Target: Integrin
ML604440
T12079
Synonym:
Target: Proteasome
ML-178
T22102
Synonym: CYM50179
Target: Others
Phenidone
T22398
Synonym: 1-phenyl-3-pyrazolidinone
Target: Lipoxygenase, COX
(Rac)-Benpyrine
T8692
Synonym:
Target: TNF
Ossirene
T6761
Synonym: AS101
Target: IL Receptor, Caspase, Interleukin
Luzindole
T15795
Synonym: N-0774
Target: Melatonin Receptor, MT Receptor
S1p receptor agonist 1
T4031
Synonym: S1p-receptor-agonist-1
Target: S1P Receptor, LPL Receptor
Piclidenoson
T7188
Synonym: CF-101,IB-MECA
Target: Apoptosis, Adenosine Receptor
Bisindolylmaleimide VIII acetate
T10549
Synonym: Ro 31-7549 acetate,Bis VIII acetate
Target: Apoptosis, PKC
HS-243
T60012
Synonym:
Target: IRAK, MAPK, CDK
Mirtazapine
T0137
Synonym: 6-Azamianserin,Org3770
Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor
Tirabrutinib hydrochloride
T12311
Synonym: ONO-4059 (hydrochloride),GS-4059 (hydrochloride)
Target: BTK
SN-011
T9137
Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901
Target: STING
Cerdulatinib hydrochloride
T6104
Synonym: Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride
Target: MLK, c-Fms, Tyrosine Kinases, Hippo pathway, JAK, Syk
TLR7/8-IN-1
T38078
Synonym: TLR7/8-IN-1
Target: TLR
JAK-STAT-IN-1
T78607
Synonym:
Target: JAK, STAT
hGPR91 antagonist 3
T62858
Synonym:
Target: GPR
Antifolate C2
T26636
Synonym: AGF 154,AGF154,AGF-154
Target: Others
Afimetoran
T39654
Synonym: BMS-986256
Target: TLR
Anisperimus HCl
T30077L
Synonym: LF 150195 HCl,Anisperimus HCl（170368-04-4 Free base）
Target: Others
PF-04957325
T12422
Synonym:
Target: PDE
Tapinarof
T4644
Synonym: GSK2894512,Benvitimod,WBI 1001
Target: AhR, Aryl Hydrocarbon Receptor
RORγt Inverse agonist 6
T12753
Synonym:
Target: ROR
CCR6 inhibitor 1
T10715
Synonym:
Target: CCR
MIF-IN-2
T60850
Synonym:
Target: Others
(R)-Lisofylline
T21694
Synonym: (R)-Lisophylline
Target: STAT
(S)-AK-242
T80678
Synonym: (-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242
Target: Others
A-1331852
T6749
Synonym:
Target: BCL
BTK-IN-16
T60542
Synonym:
Target: BTK
β-Aminoarteether
T38723
Synonym: β-Aminoarteether,SM934 free base
Target: Others
Canakinumab
T73695
Synonym: ACZ 885,Ilaris
Target: IL Receptor
JAK3-IN-7
T10009
Synonym:
Target: JAK
1 2 3 4 5 6
Cat No. Product Name Synonyms Targets
T13808 P-Coumaric Acid Ethyl Ester Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate Others , Drug Metabolite
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) is the ethyl ester of p-Coumaric acid. p-Coumaric Acid is a common dietary polyphenol and also a potent immunosuppressive agent in treating autoimmune inflammato...
TQ0295 Coumestrol Estrogen Receptor/ERR
Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.
T14854 Caerulomycin A Cerulomycin,Caerulomycin Antifungal
Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound. Which induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antif...
T10835 Cletoquine Desethylhydroxychloroquine Parasite , Antifection
Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatme...
T5S1285 (+)-(3R,8S)-Falcarindiol Falcarindiol Others
1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov...
T5S1058 Triptonide PG 492,NSC 165677 Apoptosis , Wnt/beta-catenin , Autophagy
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, an...
T3877 Esculentoside A NF-κB , COX
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun...
T3426 Bacoside A MMP , Others , TNF , Dopamine Receptor , NOS , ROS
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat...
T3775 Armepavine R-Armepavine,(-)-Armepavine IκB/IKK , NF-κB
Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.
T78492 D-Mannuronic acid sodium
Sodium D-mannuronate, derived from the seaweed Macrocystis pyrifera, shows promise as a therapeutic agent in studies of autoimmune encephalomyelitis (EAE), adjuvant-induced arthritis (AIA), nephrotic syndrome, and acute ...
T36845 Isogarcinol
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppres...
T72208 1-Dehydro-[10]-gingerdione
1-Dehydro-[10]-gingerdione inhibits IKKβ activity by targeting its activation loop, thereby preventing IKKβ-mediated phosphorylation of IκBα in macrophages stimulated by agonists. Furthermore, this compound suppresses LP...

Natural Products

p-Coumaric Acid Ethyl Ester
T13808
Synonym: Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate
Target: Others, Drug Metabolite
Coumestrol
TQ0295
Synonym:
Target: Estrogen Receptor/ERR
Caerulomycin A
T14854
Synonym: Cerulomycin,Caerulomycin
Target: Antifungal
Cletoquine
T10835
Synonym: Desethylhydroxychloroquine
Target: Parasite, Antifection
(+)-(3R,8S)-Falcarindiol
T5S1285
Synonym: Falcarindiol
Target: Others
Triptonide
T5S1058
Synonym: PG 492,NSC 165677
Target: Apoptosis, Wnt/beta-catenin, Autophagy
Esculentoside A
T3877
Synonym:
Target: NF-κB, COX
Bacoside A
T3426
Synonym:
Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS
Armepavine
T3775
Synonym: R-Armepavine,(-)-Armepavine
Target: IκB/IKK, NF-κB
D-Mannuronic acid sodium
T78492
Synonym:
Target:
Isogarcinol
T36845
Synonym:
Target:
1-Dehydro-[10]-gingerdione
T72208
Synonym:
Target:

Recombinant Proteins

Species：
Human (154)
Mouse (68)
Rat (35)
Cynomolgus (22)
Rhesus (21)
Canine (11)
Cynomolgus,Rhesus (7)
Rabbit (2)
Ferret (1)
Guinea pig (1)
Expression System：
HEK293 (244)
E. coli (40)
Human Cells (23)
Baculovirus-Insect Cells (14)
CHO (3)
Yeast (2)
Baculovirus (1)
Tag：
His (104)
hFc (72)
Tag Free (43)
His,AVI (14)
mFc (13)
hFc,AVI (11)
C-6His (9)
C-His (7)
His,hFc (7)
C-Fc (6)
Cat No. Product Name Species Expression System
TMPY-02970 CXCL10 Protein, Human, Recombinant Human E. coli
(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor couple...
TMPY-04874 IL-23 P19/IL23A Protein, Human, Recombinant (hFc) Human HEK293
IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, t...
TMPY-04493 BCMA/TNFRSF17 Protein, Human, Recombinant (rFc) Human HEK293
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in...
TMPY-05319 BCMA/TNFRSF17 Protein, Human, Recombinant (His) Human HEK293
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in...
TMPY-05568 BCMA/TNFRSF17 Protein, Human (His & hFc), PE conjugated Human HEK293
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in...
TMPY-03213 BCMA/TNFRSF17 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in...
TMPY-02279 Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His) Human E. coli
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key en...
TMPY-05480 IL-21R Protein, Human, Recombinant (hFc) Human HEK293
Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil...
TMPY-05446 CD200 Protein, Human, Recombinant (hFc) Human HEK293
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through ...
TMPY-00072 GITR/TNFRSF18 Protein, Human, Recombinant (His) Human HEK293
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)...
TMPY-00418 IL-21R Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil...
TMPY-01934 IL-21R Protein, Human, Recombinant (His) Human HEK293
Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R, and NILR, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 4 subfamil...
TMPY-03855 DNase I Protein, Human, Recombinant (His) Human HEK293
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phos...
TMPY-01214 IL-6R Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-01621 TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) Human HEK293
Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not ...
TMPY-05227 TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated Human HEK293
Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not ...
TMPY-01066 MICB Protein, Human, Recombinant (His) Human HEK293
MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related prote...
TMPY-00864 IL-6R Protein, Human, Recombinant (His) Human HEK293
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-05278 IL-6R Protein, Human, Recombinant (hFc) Human HEK293
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In...
TMPY-00033 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc) Human HEK293
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as de...
TMPY-04832 OX40L/TNFSF4 Protein, Human, Recombinant (hFc) Human HEK293
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-med...
TMPY-04845 IL-3 Protein, Mouse, Recombinant Mouse HEK293
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cell...
TMPY-05274 IL-23R Protein, Human, Recombinant (His) Human HEK293
IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK, and dendritic cells. Isofo...
TMPY-00297 IL-3 Protein, Human, Recombinant(aa 20-152) Human E. coli
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cell...
TMPY-01963 IL-21 Protein, Human, Recombinant Human E. coli
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellul...
TMPY-00095 IL-3 Protein, Human, Recombinant (His) Human HEK293
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cell...
TMPY-01371 IL-17RA Protein, Human, Recombinant (His) Human HEK293
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secret...
TMPY-00674 B7-1 Protein, Human, Recombinant Human HEK293
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B c...
TMPY-02779 Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His) Human Baculovirus-Insect Cells
Thyroid peroxidase is a membrane-bound glycoprotein which belongs to the peroxidase family, XPO subfamily. It contains 1 EGF-like domain and 1 Sushi (CCP/SCR) domain. Thyroid Peroxidase represents one of the main autoant...
TMPY-01423 OX40/TNFRSF4 Protein, Human, Recombinant (His) Human HEK293
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a rea...
TMPY-00705 CD30L Protein, Human, Recombinant (hFc) Human HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPY-02900 IL-17A Protein, Mouse, Recombinant Mouse E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-02886 IL-17A Protein, Human, Recombinant Human E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions i...
TMPY-04289 CD30L Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell s...
TMPY-00981 ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK) Human HEK293
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-03356 IFN gamma Protein, Mouse, Recombinant Mouse HEK293
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-00854 IL-1 alpha/IL-1A Protein, Human, Recombinant Human HEK293
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPY-01714 IFN gamma Protein, Human, Recombinant Human CHO
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-06983 IFN gamma Protein, Human, Recombinant (E. coli) Human E. coli
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-01142 ICAM-1/CD54 Protein, Human, Recombinant (His) Human HEK293
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-02827 IFN gamma Protein, Rat, Recombinant (hFc) Rat HEK293
IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, ...
TMPY-06981 IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) Human E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPY-01738 IL-1 alpha/IL-1A Protein, Mouse, Recombinant Mouse E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPY-01349 ICAM-1/CD54 Protein, Mouse, Recombinant (His) Mouse HEK293
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-05017 ICAM-1/CD54 Protein, Rhesus, Recombinant (His) Rhesus HEK293
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-05260 PD-1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-04342 PD-1 Protein, Canine, Recombinant (His) Canine HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-00897 PD-1 Protein, Human, Recombinant (His) Human HEK293
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyr...
TMPY-03670 PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune res...
TMPY-04345 PD-L1 Protein, Rat, Recombinant (His) Rat HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune res...
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CXCL10 Protein, Human, Recombinant
TMPY-02970
Species: Human
Expression System: E. coli
IL-23 P19/IL23A Protein, Human, Recombinant (hFc)
TMPY-04874
Species: Human
Expression System: HEK293
BCMA/TNFRSF17 Protein, Human, Recombinant (rFc)
TMPY-04493
Species: Human
Expression System: HEK293
BCMA/TNFRSF17 Protein, Human, Recombinant (His)
TMPY-05319
Species: Human
Expression System: HEK293
BCMA/TNFRSF17 Protein, Human (His & hFc), PE conjugated
TMPY-05568
Species: Human
Expression System: HEK293
BCMA/TNFRSF17 Protein, Rhesus, Recombinant (hFc)
TMPY-03213
Species: Rhesus
Expression System: HEK293
Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)
TMPY-02279
Species: Human
Expression System: E. coli
IL-21R Protein, Human, Recombinant (hFc)
TMPY-05480
Species: Human
Expression System: HEK293
CD200 Protein, Human, Recombinant (hFc)
TMPY-05446
Species: Human
Expression System: HEK293
GITR/TNFRSF18 Protein, Human, Recombinant (His)
TMPY-00072
Species: Human
Expression System: HEK293
IL-21R Protein, Mouse, Recombinant (His)
TMPY-00418
Species: Mouse
Expression System: HEK293
IL-21R Protein, Human, Recombinant (His)
TMPY-01934
Species: Human
Expression System: HEK293
DNase I Protein, Human, Recombinant (His)
TMPY-03855
Species: Human
Expression System: HEK293
IL-6R Protein, Mouse, Recombinant (His)
TMPY-01214
Species: Mouse
Expression System: HEK293
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His)
TMPY-01621
Species: Human
Expression System: HEK293
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated
TMPY-05227
Species: Human
Expression System: HEK293
MICB Protein, Human, Recombinant (His)
TMPY-01066
Species: Human
Expression System: HEK293
IL-6R Protein, Human, Recombinant (His)
TMPY-00864
Species: Human
Expression System: HEK293
IL-6R Protein, Human, Recombinant (hFc)
TMPY-05278
Species: Human
Expression System: HEK293
4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc)
TMPY-00033
Species: Human
Expression System: HEK293
OX40L/TNFSF4 Protein, Human, Recombinant (hFc)
TMPY-04832
Species: Human
Expression System: HEK293
IL-3 Protein, Mouse, Recombinant
TMPY-04845
Species: Mouse
Expression System: HEK293
IL-23R Protein, Human, Recombinant (His)
TMPY-05274
Species: Human
Expression System: HEK293
IL-3 Protein, Human, Recombinant(aa 20-152)
TMPY-00297
Species: Human
Expression System: E. coli
IL-21 Protein, Human, Recombinant
TMPY-01963
Species: Human
Expression System: E. coli
IL-3 Protein, Human, Recombinant (His)
TMPY-00095
Species: Human
Expression System: HEK293
IL-17RA Protein, Human, Recombinant (His)
TMPY-01371
Species: Human
Expression System: HEK293
B7-1 Protein, Human, Recombinant
TMPY-00674
Species: Human
Expression System: HEK293
Thyroid peroxidase Protein, Human, Recombinant (S257A & P725T, His)
TMPY-02779
Species: Human
Expression System: Baculovirus-Insect Cells
OX40/TNFRSF4 Protein, Human, Recombinant (His)
TMPY-01423
Species: Human
Expression System: HEK293
CD30L Protein, Human, Recombinant (hFc)
TMPY-00705
Species: Human
Expression System: HEK293
IL-17A Protein, Mouse, Recombinant
TMPY-02900
Species: Mouse
Expression System: E. coli
IL-17A Protein, Human, Recombinant
TMPY-02886
Species: Human
Expression System: E. coli
CD30L Protein, Cynomolgus, Recombinant (His)
TMPY-04289
Species: Cynomolgus
Expression System: HEK293
ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK)
TMPY-00981
Species: Human
Expression System: HEK293
IFN gamma Protein, Mouse, Recombinant
TMPY-03356
Species: Mouse
Expression System: HEK293
IL-1 alpha/IL-1A Protein, Human, Recombinant
TMPY-00854
Species: Human
Expression System: HEK293
IFN gamma Protein, Human, Recombinant
TMPY-01714
Species: Human
Expression System: CHO
IFN gamma Protein, Human, Recombinant (E. coli)
TMPY-06983
Species: Human
Expression System: E. coli
ICAM-1/CD54 Protein, Human, Recombinant (His)
TMPY-01142
Species: Human
Expression System: HEK293
IFN gamma Protein, Rat, Recombinant (hFc)
TMPY-02827
Species: Rat
Expression System: HEK293
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
TMPY-06981
Species: Human
Expression System: E. coli
IL-1 alpha/IL-1A Protein, Mouse, Recombinant
TMPY-01738
Species: Mouse
Expression System: E. coli
ICAM-1/CD54 Protein, Mouse, Recombinant (His)
TMPY-01349
Species: Mouse
Expression System: HEK293
ICAM-1/CD54 Protein, Rhesus, Recombinant (His)
TMPY-05017
Species: Rhesus
Expression System: HEK293
PD-1 Protein, Cynomolgus, Recombinant (His)
TMPY-05260
Species: Cynomolgus
Expression System: HEK293
PD-1 Protein, Canine, Recombinant (His)
TMPY-04342
Species: Canine
Expression System: HEK293
PD-1 Protein, Human, Recombinant (His)
TMPY-00897
Species: Human
Expression System: HEK293
PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His)
TMPY-03670
Species: Cynomolgus,Rhesus
Expression System: HEK293
PD-L1 Protein, Rat, Recombinant (His)
TMPY-04345
Species: Rat
Expression System: HEK293
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Cat No. Product Name
L4700 Immunology/Inflammation Compound Library

3483 compounds
A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.
L9000 Apoptosis Compound Library

1796 compounds
A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
L3600 Cytokine Inhibitor Library

613 compounds
A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;

Libraries

Immunology/Inflammation Compound Library
L4700
Compounds: 3483
Apoptosis Compound Library
L9000
Compounds: 1796
Cytokine Inhibitor Library
L3600
Compounds: 613
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