autoimmune

Infliximab is a monoclonal antibody, a human-mouse chimeric monoclonal antibody that inhibits TNF-α and prevents TNF-α from interacting with TNFR1 and TNFR2. Infliximab can be used to treat Crohn's disease and rheumatoid arthritis.

Rituximab is an anti-CD20 chimeric monoclonal antibody used to study certain autoimmune diseases and cancers.

Angiogenin (108-122) is an angiogenin peptide that serves as a therapeutic agent for the prophylaxis and or treatment of cancer, infectious diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, autoimmune diseases, and heart and vascular diseases.

Myosin H Chain Fragment, mouse acetate salt, a segment of the α-Myosin heavy chain peptide, is crucial for developing the experimental autoimmune myocarditis (EAM) mouse model [1] [2].

AChRα(97-116), a peptide implicated in the induction of experimental autoimmune myasthenia gravis (EAMG), serves as a targeted agent in this autoimmune disorder [1].

J5 peptide, an MBP inhibitor, competitively inhibits the binding of MBP 85-99 to HLA-DR2, and mitigates PLP 139-151 MBP 85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. It is utilized in research pertaining to inflammatory and immune diseases [1].

Forigerimod TFA (IPP-201101 TFA), a CD4 T-cell modulator, is a phosphorylated 21-amino-acid fragment derived from U1 small nuclear ribonucleoprotein 70 kDa, specifically at Ser140. It notably inhibits autophagy and is utilized in researching autoimmune disorders, including systemic lupus erythematosus (SLE) [1] [2] [3] [4].

MOG (92–106), mouse, rat, is a biologically active peptide corresponding to the fragment of amino acids 92 to 106 in myelin oligodendrocyte glycoprotein (MOG) from mice and rats. Mice subjected to MOG (92–106)-induced experimental autoimmune encephalomyelitis show substantial B cell reactivity to secondary myelin antigens. Although this MOG fragment elicits only modest T cell responses, the resultant autoimmunity is profoundly severe. The peptide demonstrates encephalitogenic properties in various species, including SJL mice, DA rats, and rhesus monkeys.

R16, an interphotoreceptor retinoid binding protein (IRBP)-derived peptide, exhibits biological activity with the capability to induce experimental autoimmune uveitis (EAU) in susceptible animal strains as a photoreceptor cell protein.

GMA-161 is a humanized IgG1 antibody targeting Fcγ receptor III (CD16). It holds potential for researching autoimmune diseases. For an isotype control, refer to Human IgG1 kappa, Isotype Control.

MOG (35-55), human, a constituent of central nervous system myelin, is distinguishable from mMOG (35-55) due to a proline-to-serine substitution at position 42. It possesses immunogenic properties and is partially cross-reactive with mMOG35–55. However, MOG (35-55), human does not induce encephalitogenic effects, and only elicits minimal clinical signs of EAE (experimental autoimmune encephalomyelitis) in comparison to the rodent peptide.

Angiogenin (108-122) TFA is an angiogenin peptide.Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurodegenerative disease, an autoimmu

Myosin H Chain Fragment, mouse, is a segment of the α-Myosin heavy chain peptide and serves as an inducer of experimental autoimmune myocarditis (EAM) in mouse models [1] [2].

LCKLSL hydrochloride is a hexapeptide compound and competitive inhibitor of membrane-bound protein A2 (AnxA2) with potential anti-angiogenic activity that inhibits the development of autoimmune encephalomyelitis (EAE) in mice.

BDC2.5 Mimotope 1040-63 is a biologically active peptide used in the investigation of type 1 diabetes (T1D), an autoimmune disease where T cells induce destruction of pancreatic islet β cells. This mimotope, originating from the TCR transgenic model (BDC2.5), facilitates the examination of antigen presentation mechanisms to islet autoantigen-specific T cells, contributing to the understanding of T cell-mediated beta-cell damage due to autoreactive T cell responses.

Ac-D-DGla-LI-Cha-C is a potent peptide inhibitor of the HCV protease, useful in research targeting various diseases, including cancer, autoimmune, fibrotic, inflammatory, neurodegenerative, infectious, lung, heart and vascular, and metabolic diseases [1].

Lib2-1, a macrocyclic peptide, inhibits the interaction between IL-17C and IL-17RE and is applicable in studying autoimmune and inflammatory diseases [1].

Peptide P60 acts as a FOXP3 inhibitor. This compound can penetrate cells to hinder FOXP3's nuclear translocation and diminish its ability to suppress transcription factors NF-κB and NFAT. Peptide P60 also suppresses the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, while enhancing effector T cell stimulation in vitro. Moreover, Peptide P60 can induce a lymphoproliferative autoimmune syndrome, displaying pathological characteristics similar to those observed in scurfy mice lacking functional Foxp3. Additionally, Peptide P60 has the potential to boost the immunogenicity of cancer and viral vaccines.

MGD010 is a bispecific antibody targeting CD32B (FcγRIIb) and CD79B. By simultaneously co-engaging CD32B (FcγRIIb) and the BCR component CD79B, MGD010 delivers an inhibitory signal, thereby suppressing activated B cells. MGD010 shows potential for research in autoimmune diseases.

Bovine Peripheral Myelin Protein P2 (53-78) is a derivative composed of amino acid residues 53 to 78 from the peripheral myelin P2 protein of bovine origin. It acts as a T cell epitope and is used to induce experimental autoimmune neuritis (EAN) in Lewis rats.

Abatacept (CTLA4Ig) is a soluble fusion protein composed of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains), functioning as a selective T-cell co-stimulation modulator and a protein drug for autoimmune diseases.

Interphotoreceptor retinoid-binding protein (651-670) (IRBP651-670), a peptide fragment of retinoid-binding protein 3 (also known as IRBP), plays a crucial role in the visual cycle by facilitating the transport of retinol and retinal between photoreceptor cells and the retinal pigment epithelium. This transport is essential for the regeneration of pigments necessary for vision. When administered at a dose of 300 µg/animal, IRBP651-670 induces autoimmune uveoretinitis in C57BL/6 mice, a model possessing the H-2b haplotype. This immunization leads to increased levels of ocular cytokines including IL-1β, IL-6, IL-17, TNF-α, and IFN-γ, promotes immune cell infiltration into the eye, and results in photoreceptor cell damage.

MOG peptide (35-55) amide, a myelin oligodendrocyte glycoprotein (MOG) fragment spanning amino acids 35 to 55, selectively stimulates CD4+ T cell expansion and induces experimental autoimmune encephalomyelitis (EAE) in animal models [1] [2] [3].

Spinoxin, a 34-residue peptide neurotoxin extracted from the venom of Heterometrus spinifer, is characterized by four disulfide bridges. It acts as a potent inhibitor of the Kv1.3 potassium channel with an IC 50 value of 63 nM. This compound is regarded as a promising molecular target for the diagnosis and treatment of a range of autoimmune disorders and cancers [1].