aromatic

Expression system: E. coli
Length: 35-282, Partial
Activity: Not Tested

Carboxypeptidase A2 (CPA) is a secreted pancreatic procarboxy-peptidase that cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group. The hydrolytic action of CPA2 was identified with a preference towards long substrates with aromatic amino acids in their C-terminal end, particularly tryptophan. CPA2 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. Three different forms of human pancreatic procarboxypeptidase A have been isolated, and the A1 and A2 forms are always secreted as monomeric proteins with different biochemical properties. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and or associated to one or two functionally different proteins, such as zymogen E, and is involved in zymogen inhibition.

Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme that belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

DOPA Decarboxylase DDC Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 55.2 kDa and the accession number is O88533.

Expression system: E. coli
Length: 208-507, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 2-355, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 106-379, Full Length of Mature protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-452, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-319, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-355, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-269, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 38-291, Full Length of Mature Protein
Activity: Not Tested

MDH1 Protein, Human, Recombinant (GST) is expressed in E. coli. The accession number is P40925.

Expression system: HEK293 Cells
Length: 17-420, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-345, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-252, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-263, Full Length
Activity: Not Tested

PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. PTS is involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. PTS also catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A), also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.

Matrix metalloproteinase-12(MMP12) is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. It can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Expression system: E. coli
Length: 1-347, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-480, Full Length
Activity: Enzyme activity

Carboxypeptidase A1 (CPA1) is secreted as a pancreatic peptidase that comes from the precursor form of inactive procarboxypeptidase. CPA1 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. It has a free C-terminal carboxyl group, with the preference of residues with aromatic or branched aliphatic side chains. CPA1 cleaves the C-terminal amide or ester bond of peptides and involves in zymogen inhibition. Three different forms of human pancreatic procarboxypeptidase A have been isolated. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and or associated to one or two functionally different proteins, such as zymogen E.

Expression system: HEK293 Cells
Length: 1-386, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-183, Full Length of Mature Protein
Activity: Not Tested