antibacterial agent 50

Antibacterial agent 50 (example 47) is a compound exhibiting antibacterial activity with minimum inhibitory concentration (MIC) values of 32, 64, and 128 mcg/mL against E. coli strains NCTC 13351, M 50, and 7 MP, respectively [WO2013030733A1].

Arcopilin A (compound Arcopilin A(1)) functions as an antibacterial agent with moderate inhibitory capabilities against fungal pathogens and Gram-positive bacteria, exhibiting IC 50 values of 8.9 μg/mL for KB-3-1 cells and 14 μg/mL for L929 cells. Notably, it can effectively eradicate preformed biofilms of Staphylococcus aureus. Additionally, Arcopilin A significantly boosts the efficacy of gentamicin (GM) and vancomycin (Vac), enhancing their activities by 115 and 31 times, respectively.

Antibacterial agent 32 exhibits potent antimicrobial activity against E. coli strains NCTC 13351, M 50, and 7 MP, with minimum inhibitory concentration (MIC) values of 1 mcg/mL, 2 mcg/mL, and 8 mcg/mL, respectively (WO2013030733A1, example 43).

Antibacterial agent 51 (example 45) is a potent antibacterial compound effective against E. coli strains NCTC 13351, M 50, and 7 MP, with MIC values of 4, 8, and 8 mcg/mL, respectively [WO2013030733A1].

Antibacterial agent 117 is an antibacterial agent with potent inhibitory activity against Gram-positive bacteria, used for developing new antibiotics against resistant strains.

Antibacterial agent 73 (compound 7a) exhibits antitubercular, antibacterial, and antifungal activities, with promising antitubercular activity (MIC of 0.65 μg/mL) against Mtb H37Rv, and also demonstrates cytotoxicity in MCF-7 breast cancer cell lines (IC 50 of 8.20 μM) [1].

Antibacterial Agent 125 exhibits potent antimicrobial activity against clinically relevant Gram-positive pathogens, displaying Minimum Inhibitory Concentration (MIC) 50 values ranging from 0.25 to 8 μM. It is suitable for researching antimicrobial resistance.

Antibacterial Agent 136 (Compound 3), an oxadiazolone antibiotic, exhibits high antibacterial potency against Methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) 50 value of 0.8 μM [1].

Antibacterial agent 143 is a potent LpxC inhibitor (IC50 = 33 nM). It blocks the rate-limiting step of LPS biosynthesis, exhibiting strong activity against Gram-negative pathogens like P. aeruginosa.

Antibacterial agent 169 (Compound 28), a pyrrolamide-type GyrB/ParE inhibitor, exhibits antibacterial properties by inhibiting Gyrase and Topo IV in Staphylococcus aureus. It has IC 50 values of 49 nmol/L and 1.513 μmol/L, respectively [1].