anti-parkinson's research

L-DOPA (Levodopa) is an orally active metabolic precursor of the neurotransmitter dopamine. It can cross the blood-brain barrier and be converted into dopamine in the brain. L-DOPA exhibits anti-hyperalgesic effects and holds potential in Parkinson’s disease research, and it can also be used to induce Parkinson’s disease models.

Safranal is the special volatile aroma compound of saffron

tau Protein/α-synuclein-IN-2 (Compound 14T) is a tau and α-synuclein inhibitor capable of crossing the blood-brain barrier. It reduces α-synuclein oligomerization in a dose-dependent manner through a thiourea linker structure. In biosensor cells, tau Protein/α-synuclein-IN-2 prevents tau aggregation seed effects. In the M17D neuroblastoma model, this compound exhibits anti-inclusion effects and reduces Aβ plaque formation. tau Protein/α-synuclein-IN-2 shows potential for Alzheimer's and Parkinson's disease research.

MAO-B-IN-39 (compound11) is a potent inhibitor of monoamine oxidase B (MAO-B), with an IC50 of 3.61 μM. It demonstrates strong NRF2 induction capabilities and exhibits significant anti-inflammatory and neuroprotective effects in oxidative stress-related in vitro models. Additionally, MAO-B-IN-39 shows high liver microsomal stability and favorable pharmacokinetic properties in mice, making it a valuable compound for Parkinson's disease research.

Evernic acid is a natural metabolite discovered in Evernia prunastri. It can cross the blood-brain barrier, inhibit TrxR1 enzyme activity and the NF-κB pathway, and exhibits neuroprotective and anti-inflammatory effects in Parkinson's disease models. It also possesses anticancer, antifungal, and antibacterial properties.

LZWL02003, an anti-neuroinflammatory agent, demonstrates a protective effect on MPP+-induced neuronal damage and reduces ROS expression. Additionally, it enhances cognition, memory, learning, and athleticism in Rotenone-induced Parkinson's disease (PD) rat models, suggesting its potential for neurodegenerative disease research [1].

Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1].

Anti-Mouse CD28 Antibody (D665) is a mouse-derived agonistic antibody targeting CD28 that can effectively induce T cell activation and has broad research value in fields such as neurological diseases, inflammation, immunology, and oncology. It can be applied to studies on the mechanisms and interventions of Parkinson's disease (PD), arthritis, and graft-versus-host disease (GVHD).

L-DOPA-d6 is the deuterium-labeled analog of L-DOPA. L-DOPA (Levodopa) serves as an orally active metabolic precursor to the neurotransmitter dopamine. It is capable of crossing the blood-brain barrier and is subsequently converted into dopamine within the brain. L-DOPA exhibits anti-hyperalgesic properties and holds potential for Parkinson's disease research.

L-DOPA-13C is the 13C labeled version of L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of the neurotransmitter dopamine. It can cross the blood-brain barrier and is transformed into dopamine within the brain. L-DOPA exhibits anti-nociceptive properties and holds potential for Parkinson's disease research.

L-DOPA-13C6 is L-DOPA labeled with 13C. L-DOPA (Levodopa) serves as an orally active metabolic precursor to the neurotransmitter dopamine. It can cross the blood-brain barrier and is converted to dopamine in the brain. L-DOPA exhibits anti-nociceptive effects and shows potential in Parkinson's disease research.

L-DOPA-2,5,6-d3 is a deuterated isotope of L-Dopa for isotope tracing. L-DOPA is an orally active metabolic precursor of the neurotransmitter dopamine, capable of crossing the blood-brain barrier and converting to dopamine within the brain. It exhibits anti-hyperalgesic effects and is utilised in Parkinson's disease research.

Isoquercetin (Standard) is a reference standard for research and analysis in studies involving Isoquercetin. 1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt/β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .

Ginkgetin (Standard) is a reference standard for research and analysis in studies involving Ginkgetin. 1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. 4. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. 5. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.

L-Dopa-D6 (Standard) is a reference standard of L-Dopa-D6 intended for quantitative analysis, quality control, and related biochemical research applications. L-DOPA-d6 is the deuterium-labeled analog of L-DOPA. L-DOPA (Levodopa) serves as an orally active metabolic precursor to the neurotransmitter dopamine. It is capable of crossing the blood-brain barrier and is subsequently converted into dopamine within the brain. L-DOPA exhibits anti-hyperalgesic properties and holds potential for Parkinson's disease research.

Curcumin monoglucoside is a flavonoid derivative with antioxidant, anti-apoptotic (Apoptosis), neuroprotective, and antibacterial properties. It can be utilized in research related to Parkinson's disease.