Search Result

Search Results for " aldose "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T14175	Aldose reductase-IN-1	AT-001,Caficrestat	Others , Reductase
	Aldose reductase-IN-1 (AT-001) is a aldose reductase inhibitor (IC50: 28.9 pM).		Others , Reductase
T75390	Aldose 1-epimerase
	Aldose 1-epimerase (mutarotases), an essential enzyme for carbohydrate metabolism, facilitates the interconversion between α- and β-anomers of hexose sugars, including glucose and galactose. This enzyme plays a vital rol...
T61555	Aldose reductase-IN-6
	Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells...
T60897	Aldose reductase-IN-5
	Aldose reductase-IN-5 is an inhibitor of aldose reductase (ALR2) that enhances the combination of inhibitory excitability and antioxidant capacity, thereby delaying the diabetes complications progress.
T62951	Aldose reductase-IN-2
	Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR) with antioxidant properties. aldose reductase-IN-2 is a promising anti-diabetic complication drug.
T61957	Aldose reductase-IN-3
	Aldose reductase-IN-3 (Compound 5) is an effective and moderately selective aldose reductase (AR) inhibitor (IC50=3.99 μ M). Aldose reductase is a molecular target involved in various inflammatory diseases (including sep...
T60601	Aldose reductase-IN-4
	Aldose reductase-IN-4 (compund IIc) is an inhibitor of aldose reductase with IC50s of 11.70 μM and 0.98 μM for ALR1 and ALR2, respectively [1].
T16910	Sorbinil		Reductase
	Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway.		Reductase
T22757	EBPC		Reductase
	EBPC is an inhibitor of aldose reductase.		Reductase
T23403	Sulindac sulfone		Reductase , COX
	Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac.		Reductase , COX
T10393	AT-007		Reductase
	AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.		Reductase
T35317	Zopolrestat	CP 73850,CP73850,CP-73850,Zopolrestatum	Reductase
	Zopolrestat (CP 73850) is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).		Reductase
T2013	Ponalrestat		Reductase
	Ponalrestat is an aldose reductase inhibitor.		Reductase
T17114	Tolrestat	AY-27773	Reductase
	Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).		Reductase
T5195	Alrestatin	AY-22284	Reductase
	Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.		Reductase
T1458	Epalrestat	ONO2235	Reductase
	Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particul...		Reductase
T15568	Imirestat	Alcon 1576,AL 1576,HOE 843	Reductase
	Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.		Reductase
T33389	Minalrestat	ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509	Reductase
	Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.		Reductase
T27583	IDD388	IDD-388,IDD 388	DNA/RNA Synthesis
	IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.		DNA/RNA Synthesis
T7478	2-Chloro-1-(4-fluorobenzyl)benzimidazole		Reductase
	2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2).		Reductase
T15756	Lidorestat	IDD-676	Reductase
	Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat...		Reductase
T67805	Oxepinac
	oxepinac is an effective and well-tolerated compound for the treatment of painful osteoarthritis. oxepinac has no teratogenic effect on mouse and rabbit fetuses in animal experiments.
T15281	Fidarestat	SNK 860	Reductase
	Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.		Reductase
T16723	Ranirestat	AS-3201	Others
	Ranirestat effective and orally active aldose reductase inhibitor ( IC50s: 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively and a Ki: 0.38 nM for recombinant human AR). Ranirestat has a neuroprotect...		Others
T25019	AL 4114	Al4114,AL-4114
	AL 4114 is used as an aldose reductase inhibitor.
T68630	M 79175
	M 79175 is an aldose reductase inhibitor.
T68651	ICI-105552
	ICI-105552 is an aldose reductase inhibitor.
T5195L	Alrestatin Sodium	AY 22284A,AY-22284A,Alrestatine sodium,AY22284A
	Alrestatin is a specific inhibitor of the aldose reductase enzyme.
T71868	Cemtirestat
	Cemtirestat is an aldose reductase inhibitor
T71052	M 16287
	M 16287 is a potent aldose reductase inhibitor.
T70968	ICI-222155
	ICI-222155 is an aldose reductase inhibitor.
T27362	FR 62765	FR62765,FR-62765
	FR 62765 is a derivative of WF-3681, an aldose reductase inhibitor.
T31075	CP-744809	UNII-U63F8E95J1,CP 744809,ARI-809
	CP-744809 is a highly selective oral small-molecule aldose reductase inhibitor.
T70579	SX 3202
	SX 3202 is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.
T35299	Zenarestat	CI1014,FR74366,FK-366,CI-1014,FR 74366,FR-74366
	Zenarestat (CI-1014, FK-366, FR-74366) is an aldose reductase inhibitor being studied as a treatment for diabetic neuropathy and cataracts.
T71057	WF 2421
	WF 2421 is an aldose reductase inhibitor produced by Humicola grisea.
T68929	Lidorestat monohydrate
	Lidorestat monohydrate is an aldose reductase inhibitor potentially for the treatment of diabetic neuropathy and diabetic complications.
T70679	Spr 210
	Spr 210 is an aldose reductase (AR) inhibitor with potential uses as a therapeutic agent for preventing and improving some diabetic complications.
T79005	6-Hydroxyluteolin
	6-Hydroxyluteolin (Compound 17), a flavonoid, exhibits inhibition of aldose reductase (AR) [1].
T16756	Risarestat	CT 112	Reductase
	Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia.		Reductase
T62456	ALR1/2-IN-1
	ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) (IC50: 3.26 μM) and aldose reductase (ALR2) (IC50: 3.06 μM) inhibitor with anticancer effects.
T73305	ALR2-IN-3
	ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, demonstrates IC50 values of 22 nM for rat ALR2 and 116 nM for ALR1, respectively. This compound is utilized in diabetic complications research.
T73304	ALR2-IN-2
	ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, exhibits IC50 values of 27 nM for rat ALR2 and 228 nM for ALR1, respectively. This compound is utilized in the research of diabetic complications.
T78612	APPA		Apoptosis
	APPA, an aldose reductase inhibitor, demonstrates efficacy in preventing apoptosis and symptoms of Streptozotocin-induced diabetes in rats through inhibition of the polyol pathway. This compound shows promise for researc...		Apoptosis
T13037	Sulindac sulfide	cis-Sulindac sulfide	Raf , Others , AChR
	Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibito...		Raf , Others , AChR
T78702	PTP1B/AKR1B1-IN-1		Phosphatase
	PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s of 0.06 μM for PTP1B and 4.3 μM for AKR1B1. Additionally, it...		Phosphatase

Compounds

Aldose reductase-IN-1

T14175

Synonym: AT-001,Caficrestat

Target: Others, Reductase

Aldose reductase-IN-6

T61555

Synonym:

Target:

Aldose reductase-IN-5

T60897

Synonym:

Target:

Aldose reductase-IN-2

T62951

Synonym:

Target:

Aldose reductase-IN-3

T61957

Synonym:

Target:

Aldose reductase-IN-4

Target: Reductase, COX

Synonym: CP 73850,CP73850,CP-73850,Zopolrestatum

Synonym: Alcon 1576,AL 1576,HOE 843

Target: Reductase

Minalrestat

T33389

Synonym: ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509

Target: Reductase

IDD388

T27583

Synonym: IDD-388,IDD 388

Target: DNA/RNA Synthesis

2-Chloro-1-(4-fluorobenzyl)benzimidazole

Synonym: Al4114,AL-4114

Synonym: AY 22284A,AY-22284A,Alrestatine sodium,AY22284A

Synonym: FR62765,FR-62765

Target:

CP-744809

T31075

Synonym: UNII-U63F8E95J1,CP 744809,ARI-809

Synonym: CI1014,FR74366,FK-366,CI-1014,FR 74366,FR-74366

Lidorestat monohydrate

Synonym: cis-Sulindac sulfide

Target: Raf, Others, AChR

Cat No.	Product Name	Synonyms	Targets
T6S2384	Poliumoside		Reductase
	Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase w...		Reductase
T5S1131	Ganoderic acid C6		Others
	1. Ganoderic acid C6 has antinociceptive activity.		Others
T0725	Isoliquiritigenin	ISL,Isoliquiritigen,GU17	Apoptosis , Influenza Virus , Reductase , Autophagy
	Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM).		Apoptosis , Influenza Virus , Reductase , Autophagy
T3801	(Rac)-Byakangelicin	Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin	Others
	(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.		Others
TN5276	(Z)-Aldosecologanin (Centauroside)		Others
	(Z)-Aldosecologanin is a natural product from Lonicera japonica.		Others
TN3908	(E)-Aldosecologanin		Others
	(E)-Aldosecologanin is a natural product from Lonicera japonica.		Others
TN1661	Ganoderic acid C2		Reductase , Histamine Receptor , Immunology/Inflammation related
	Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.
TN1975	Neosmitilbin	Neoastilbin	Others
	Neosmitilbin (Neoastilbin) may have antioxidant and anti-inflammatory activities, it shows potent inhibition of lens aldose reductase.		Others
TN1656	Ganoderenic acid A		Others
	Ganoderenic acid A has a potent hepatoprotective, and cytotoxic effects, it shows inhibitory activity on human aldose reductase in vitro.		Others
T5S1026	Apigenin-7-glucuronide	Apigenin 7-O-glucuronide	MMP
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 1...		MMP
T6S0840	Engeletin	Dihydrokaempferol 3-rhamnoside	NF-κB , Reductase
	1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant ...		NF-κB , Reductase
T3665	Tectoridin	Shekanin	Estrogen Receptor/ERR , Reductase
	Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an...		Estrogen Receptor/ERR , Reductase
TN2122	Quercetin 3-gentiobioside	Quercetin-3-gentiobioside	Reductase
	Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) is an inhibitor of AR and AGE formation and can be extracted from A. iwayomogi.Quercetin 3-gentiobioside inhibits the biological activity of aldose reductase (AR) and...		Reductase
TN1037	Groenlandicine		Topoisomerase
	Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Groenlandicine selectively ...		Topoisomerase
T4704	L-Anserine nitrate	L-Anserine nitrate salt	Others , Endogenous Metabolite
	L-Anserine nitrate (L-Anserine nitrate salt) is a dipeptide found in most animal tissues. In model systems it is a potent Antioxidant and scavener of hydroxyl radicals. The compound inhibits nonenzymatic protein glycatio...		Others , Endogenous Metabolite
T5S1988	Isorhamnetin-3-O-glucoside	Isorhamnetin-3-O-beta-D-Glucoside	Others
	Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1....		Others
T5813	BYAKANGELICIN		Reductase
	BYAKANGELICIN,a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor,and is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lea...		Reductase
T2S1635	3-Isomangostin		MTH1
	3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial ac...		MTH1
T6102	2'-acetylacteoside		Antioxidant , Reductase
	2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smoo...		Antioxidant , Reductase
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
T4918	DL-Glyceraldehyde	Glyceric aldehyde	Reductase
	DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ...		Reductase
TN5183	Triptocalline A		Others
	Triptocalline A shows an inhibitory effect on rat lens aldose reductase.		Others
T39435	Myrciacetin
	Myrciacetin, a flavonoid derived from Rhododendron dauricum, exhibits inhibitory activity against rat lens aldose reductase, as demonstrated by an IC50 value of 13 μM.
TN3287	8-Lavandulylkaempferol		Reductase , AChR
	8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows inhibitory activities against aldose re...		Reductase , AChR
TN5672	Puerol A
	Puerol A exhibits potent inhibitory effects on aldose reductase with IC50 values of 6.4 uM. dl-Puerol A has antioxdiant activity, it shows inhibitory effects on copper ion-induced protein oxidative modification of mouse ...
T75627	Ganoderic acid Df
	Ganoderic acid Df, a lanostane-type triterpenoid isolated from the fruiting body of Ganoderma lucidum, potently inhibits aldose reductase with an IC 50 of 22.8 ± 0.6 μM [1].
T10183	6-Methoxytricin		Others
	6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ...		Others
TN6645	Lucidumol A
	Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependen...
TMA0291	Dehydroglyasperin D		GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit...
TN3760	Danshenol A		Reductase
	Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and B...		Reductase
TN3692	Conduritol A		TNF
	Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly preve...		TNF

Natural Products

Synonym: ISL,Isoliquiritigen,GU17

Target: Apoptosis, Influenza Virus, Reductase, Autophagy

(Rac)-Byakangelicin

T3801

Synonym: Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin

Target: Others

(Z)-Aldosecologanin (Centauroside)

TN5276

Synonym:

Target: Others

(E)-Aldosecologanin

Target: Reductase, Histamine Receptor, Immunology/Inflammation related

Apigenin-7-glucuronide

T5S1026

Synonym: Apigenin 7-O-glucuronide

Target: MMP

Engeletin

T6S0840

Synonym: Dihydrokaempferol 3-rhamnoside

Target: NF-κB, Reductase

Tectoridin

T3665

Synonym: Shekanin

Target: Estrogen Receptor/ERR, Reductase

Quercetin 3-gentiobioside

TN2122

Synonym: Quercetin-3-gentiobioside

Target: Topoisomerase

L-Anserine nitrate

T4704

Synonym: L-Anserine nitrate salt

Target: Others, Endogenous Metabolite

Isorhamnetin-3-O-glucoside

T5S1988

Synonym: Isorhamnetin-3-O-beta-D-Glucoside

Target: Antioxidant, Reductase

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

DL-Glyceraldehyde

T4918

Synonym: Glyceric aldehyde

8-Lavandulylkaempferol

TN3287

Synonym:

Target: Reductase, AChR

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01264	GALM Protein, Human, Recombinant (His)	Human	E. coli
	Galactose Mutarotase (GALM) is a cytoplasmic enzyme that belongs to the Aldose Epimerase family. GALM is a Mutarotase that converts α-Aldose to the β-Anomer. GALM is active on D-Glucose, L-Arabinose, D-Xylose, D-Galactos...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest...
TMPJ-00524	SORD Protein, Human, Recombinant (His)	Human	Human Cells
	Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expresse...

GALM Protein, Human, Recombinant (His)

TMPJ-01264

Species: Human

Expression System: E. coli

AKR1B1 Protein, Human, Recombinant (His)

TMPY-02438

Species: Human

Expression System: E. coli

SORD Protein, Human, Recombinant (His)

TMPJ-00524

Species: Human

Expression System: Human Cells