Penicillinase

Penicillinase, a beta-lactamase enzyme, inactivates beta-lactam antibiotics by hydrolyzing the peptide bond of the characteristic four-membered beta-lactam ring, rendering the antibiotic ineffective [1].

Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

Cephalosporin C exhibits relatively weak resistance to Gram-positive and Gram-negative bacteria. It is stable against penicillinase, but can be decomposed by cephalosporinase. When hydrolyzed to remove its side chain, it yields 7-amino-cefenoic acid (7-ACA), which is an essential raw material for the production of semisynthetic cephalosporins.

Bharangin is a inhibitor of penicillinase enzyme in E coli.

Pipacycline is a tetracycline antibiotic derivative. It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.

Nafcillin sodium monohydrate (Standard) is the standard substance of Nafcillin sodium monohydrate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nafcillin sodium monohydrate (CL 8491) is the sodium salt form of nafcillin, a semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci.

Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a penicillin that resists Penicillinase and exhibits antibacterial activity. It shows effective activity against Gram-positive cocci. Diphenicillin is promising for research on infectious diseases caused by Gram-positive bacteria such as staphylococci, pneumococci, and group A streptococci.

Dotriacolide is a β-lactamase inhibitor with notable inhibitory activity against penicillinase and cephalosporinase, displaying ID50 values of 0.61 μg/mL and 0.15 μg/mL respectively. It holds potential for research in infectious diseases.