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Search Result

Search Results for " orthopoxvirus "

Targets

Others

25

Compounds

8

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7142 Cephalosporin C zinc salt Others
Cephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 µM), and this inhibition was largely attributable to the presence of zinc.
T6360 3-deazaneplanocin A HCl Others , Histone Methyltransferase
3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
T40686 Tiazofurin NSC 286193,Riboxamide Dehydrogenase
Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) in...
T7655 Fialuridine DRG-0098,FIAU DNA/RNA Synthesis
Fialuridine (DRG-0098) is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and in vivo.
T6446 Clevudine L-FMAU,Levovir HBV , DNA/RNA Synthesis
Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...
T4683 Alovudine 3'-Deoxy-3'-fluorothymidine Antiviral
Alovudine (3'-Deoxy-3'-fluorothymidine) is a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and is a better biomarker in pancreatic cancer.
TQ0095 Brincidofovir CMX001,HDP-CDV Others , Antiviral , HSV
Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses.
T6588 Mitoxantrone mitozantrone Topoisomerase , PKC
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome...
T1617 Enrofloxacin BAY-Vp2674,PD160788 DNA/RNA Synthesis , Antibacterial , Antibiotic
Enrofloxacin (BAY-Vp2674) is a veterinary antibacterial agent, used in poultry.
T6136 Canertinib PD-183805,CI-1033 EGFR
Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp...
T0992 Carbenoxolone disodium Biogastrone,Duogastrone,Bioral Gap Junction Protein
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ...
T0902 Ofloxacin DL8280,Hoe-280,Floxin,Tarivid,Oxaldin Topoisomerase , Antibacterial , Antibiotic
Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting i...
T6244 Cidofovir HPMPC,GS 0504,(S)-HPMPC Others , DNA/RNA Synthesis
Cidofovir ((S)-HPMPC) inhibits virus replication by specific inhibition of viral DNA synthesis.
T0684 Ribavirin Tribavirin,ICN-1229,NSC-163039,RTCA Dehydrogenase , HCV Protease , DNA/RNA Synthesis , Antibiotic , AChR , RSV
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T0863 Idoxuridine IDU,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid Antifection , HSV
Idoxuridine (Dendrid) is an analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.
T8736 Cidofovir dihydrate HPMPC,(S)-HPMPC,GS 0504 Others
Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ...
T1428 Trifluridine NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,Viroptic,Trifluridina Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , HSV
Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibi...
T6292 3-Deazaneplanocin A Histone Methyltransferase
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
T0158 Mitoxantrone dihydrochloride Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride Topoisomerase , PKC
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
T2501 Canertinib dihydrochloride CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib EGFR
Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities.
T1406 Amantadine hydrochloride 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride Dopamine Receptor , Influenza Virus
Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.
T61824 NIOCH 14
NIOCH 14 is an antiviral agent and pro-drug with demonstrated potency against orthopoxviruses. It exhibits significant efficacy in reducing infection rates and lung viral load in mice. NIOCH 14 is particularly useful for...
T60876 HOE961
HOE961 is the diacetate ester prodrug of S2242 with anti-orthopoxvirus activity. HOE961 is orally active in infection models. HOE961 is active against respiratory cowpox virus infections [1].
T60970 Caprochlorone
Caprochlorone exhibits antiviral activity against orthopoxvirus that decreases the influenza virus titers in infected-mice lungs. Caprochlorone can inhibit cell penetration by virus as well as delays newly formed virus r...
T63997 Mitoxantrone diacetate
Mitoxantrone diacetate is a potent inhibitor of topoisomerase II. Mitoxantrone diacetate also inhibits protein kinase C (PKC) (IC50: 8.5 μM). Mitoxantrone diacetate exhibits antitumour effects and also has an antiorthopo...

Compounds

Cephalosporin C zinc salt
T7142
Synonym:
Target: Others
3-deazaneplanocin A HCl
T6360
Synonym:
Target: Others, Histone Methyltransferase
Tiazofurin
T40686
Synonym: NSC 286193,Riboxamide
Target: Dehydrogenase
Fialuridine
T7655
Synonym: DRG-0098,FIAU
Target: DNA/RNA Synthesis
Clevudine
T6446
Synonym: L-FMAU,Levovir
Target: HBV, DNA/RNA Synthesis
Alovudine
T4683
Synonym: 3'-Deoxy-3'-fluorothymidine
Target: Antiviral
Brincidofovir
TQ0095
Synonym: CMX001,HDP-CDV
Target: Others, Antiviral, HSV
Mitoxantrone
T6588
Synonym: mitozantrone
Target: Topoisomerase, PKC
Enrofloxacin
T1617
Synonym: BAY-Vp2674,PD160788
Target: DNA/RNA Synthesis, Antibacterial, Antibiotic
Canertinib
T6136
Synonym: PD-183805,CI-1033
Target: EGFR
Carbenoxolone disodium
T0992
Synonym: Biogastrone,Duogastrone,Bioral
Target: Gap Junction Protein
Ofloxacin
T0902
Synonym: DL8280,Hoe-280,Floxin,Tarivid,Oxaldin
Target: Topoisomerase, Antibacterial, Antibiotic
Cidofovir
T6244
Synonym: HPMPC,GS 0504,(S)-HPMPC
Target: Others, DNA/RNA Synthesis
Ribavirin
T0684
Synonym: Tribavirin,ICN-1229,NSC-163039,RTCA
Target: Dehydrogenase, HCV Protease, DNA/RNA Synthesis, Antibiotic, AChR, RSV
Idoxuridine
T0863
Synonym: IDU,SKF 14287,5-Iodo-2′-deoxyuridine,NSC 39661,5-IUdR,Dendrid
Target: Antifection, HSV
Cidofovir dihydrate
T8736
Synonym: HPMPC,(S)-HPMPC,GS 0504
Target: Others
Trifluridine
T1428
Synonym: NSC 529182,Trifluorothymidine,5-Trifluorothymidine,NSC 75520,Viroptic,Trifluridina
Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, HSV
3-Deazaneplanocin A
T6292
Synonym:
Target: Histone Methyltransferase
Mitoxantrone dihydrochloride
T0158
Synonym: Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride
Target: Topoisomerase, PKC
Canertinib dihydrochloride
T2501
Synonym: CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib
Target: EGFR
Amantadine hydrochloride
T1406
Synonym: 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride
Target: Dopamine Receptor, Influenza Virus
NIOCH 14
T61824
Synonym:
Target:
HOE961
T60876
Synonym:
Target:
Caprochlorone
T60970
Synonym:
Target:
Mitoxantrone diacetate
T63997
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T4729 Phosphonoacetic acid Endogenous Metabolite
Phosphonoacetate, also known as fosfonet or phosphonacetic acid, belongs to the class of organic compounds known as organic phosphonic acids.Within the cell, phosphonoacetate is primarily located in the cytoplasm. Phosph...
T0974 Novobiocin Sodium Albamycinsodium,Cathomycin,Albamycin Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T0681 Rifampicin Rifamycin AMP,Rimactane,Rifampin Influenza Virus , DNA/RNA Synthesis , Antibacterial , Antibiotic , Antifection
Rifampicin (Rifamycin AMP) is an antibacterial drug of the class of rifamycin.
T4971 5'-DEOXYADENOSINE 5′-dAdo Endogenous Metabolite
5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long be...
T6567 Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin Topoisomerase , Antibacterial , Antibiotic
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
T1272 Cytarabine Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , HSV
Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
T1506 Vidarabine Adenine Arabinoside,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A Nucleoside Antimetabolite/Analog , Tyrosine Kinases , DNA/RNA Synthesis , Antibiotic , HSV
Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and signific...
T7060 Amantadine 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine Others
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.

Natural Products

Phosphonoacetic acid
T4729
Synonym:
Target: Endogenous Metabolite
Novobiocin Sodium
T0974
Synonym: Albamycinsodium,Cathomycin,Albamycin
Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy
Rifampicin
T0681
Synonym: Rifamycin AMP,Rimactane,Rifampin
Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic, Antifection
5'-DEOXYADENOSINE
T4971
Synonym: 5′-dAdo
Target: Endogenous Metabolite
Levofloxacin
T6567
Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin
Target: Topoisomerase, Antibacterial, Antibiotic
Cytarabine
T1272
Synonym: Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine
Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV
Vidarabine
T1506
Synonym: Adenine Arabinoside,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A
Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV
Amantadine
T7060
Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine
Target: Others

Recombinant Proteins

Species：
Monkeypox virus (4)
Expression System：
HEK293 (3)
E. coli (1)
Tag：
C-His (2)
N-His (2)
Cat No. Product Name Species Expression System
TMPK-01253 A35R Protein, Monkeypox virus, Recombinant (His) Monkeypox virus HEK293
Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans.
TMPK-01250 M1R Protein, Monkeypox virus, Recombinant (His) Monkeypox virus HEK293
Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans.
TMPK-01123 A29 Protein, Monkeypox virus, Recombinant (His) Monkeypox virus E. coli
Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans.
TMPK-01116 A30 Protein, Monkeypox virus, Recombinant (His) Monkeypox virus HEK293
Monkeypox virus (MPXV) is double-stranded DNA virus belonging to the genus orthopoxvirus that causes a smallpox-like disease in humans. A30L is an envelope protein required for the fusion of virus and host cell to form s...
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