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Search Results for " ngf "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T16766	Ro 08-2750
	Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2...
T6052	GW 441756		Apoptosis , Raf , Trk receptor , CDK
	GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.		Apoptosis , Raf , Trk receptor , CDK
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
TP2258	HNGF6A		Others
	increases glucose stimulated insulin secretion and glucose metabolism		Others
T75833	HNGF6A TFA
	HNGF6A TFA, a humanin analogue, enhances glucose-stimulated insulin secretion and glucose metabolism, offering potential for diabetes research. It also inhibits ROS (Reactive Oxygen Species) production under oxidative st...
T12384	PD 90780		Others
	PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC1...		Others
T67980	Coleneuramide	MCC-257	Others
	Coleneuramide (MCC-257) enhances the effect of nerve growth factor (NGF) on cell survival and can be used to study diabetic polyneuropathy.		Others
T9292	ALE-0540	ALE0540	Others , Trk receptor
	ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.		Others , Trk receptor
T4093	Fabomotizole hydrochloride	Afobazole hydrochloride,CM346 hydrochloride	MAO
	Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro...		MAO
T15602	ITX3		Others , Rho
	ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange on RhoG and Rac1, inhibits NGF-mediated neurite growth in P...		Others , Rho
T77147	Relfovetmab
	Relfovetmab is an anti- NGF monoclonal antibody (mAb) [1] .
T78280	Fasinumab
	Fasinumab (Anti-Human NGF), a human IgG1κ monoclonal antibody targeting nerve growth factor (NGF), has applications in clinical studies for acute sciatica and knee osteoarthritis (OA) [1].
T26050	RC-33 HCl	RC 33 Hydrochloride,RC-33 Hydrochloride,RC33 Hydrochloride
	RC-33 HCl is a selective and metabolically stable σ1 receptor agonist potentiating NGF-induced neurite outgrowth.
T31761	Fellutamide A
	Fellutamide A as a tripeptide derivative from Penicillium fellutanum can enhance nerve growth factor (NGF) synthesis and secretion in vitro.
T38947	Udonitrectag	REC 0559
	Udonitrectag (REC 0559) is a low molecular weight compound developed to emulate the behavior of NGF, with the objective of tackling the challenge of maintaining NGF stability.
T33858	PACA	N-Propargyl Caffeamide
	PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor...
T82367	Fulranumab
	Fulranumab, a human IgG2 monoclonal antibody targeting nerve growth factor (NGF), is utilized in pain research [1].
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841), a canine monoclonal antibody (mAb) designed to target nerve growth factor (NGF), prevents NGF from interacting with its receptors, tropomyosin receptor kinase A (trkA) and p75 neurotrophin rec...
T29543	ACAF4	ACAF-4,ACAF 4
	ACAF4 is a neurotrophic agent which significantly increases survival in PC12 neuronal cells and enhances the effect of nerve growth factor (NGF). ACAF4 induces neurite outgrowth, and modulates ERK1/2 and AKT signaling pa...
T78316	Frunevetmab	NV-02
	Frunevetmab (NV-02), a felinized monoclonal antibody targeting nerve growth factor (NGF), exhibits a high affinity with a dissociation constant (Kd) of 20 pM and has been demonstrated to effectively mitigate osteoarthrit...
T24272	KT5926	KT 5926,KT-5926
	KT5926 is an effective and selective inhibitor of myosin light chain kinase. KT5926 is an analogue of K-252a, which blocks all responses to NGF. KT5926 selectively inhibits nerve growth factor-dependent neurite elongatio...
T77142	Ranevetmab
	Ranevetmab (NV-01), a caninized anti-nerve growth factor (anti-NGF) monoclonal antibody (mAb), is utilized in research for alleviating pain associated with degenerative joint disease (DJD) in canines.
T78282	Tanezumab	RN-624,PF 4383119
	Tanezumab (RN-624) is a high-affinity, specific humanized anti-NGF monoclonal antibody (mAb) that inhibits nerve growth factor (NGF) from binding to its p75 and TrkA receptors in the peripheral nervous system. It is util...
T29598	Acetylcarnitine arginyl amide	ST-857,acetyl-L-carnitine arginine amide
	Acetylcarnitine arginyl amide is able to stimulate neurite outgrowth in a manner similar to that elicited by nerve growth factor (NGF). Neurite induction by this molecule requires de novo mRNA synthesis and is independen...
T63965	Bepotastine tosylate
	Bepotastine tosylate is a selective, orally active second-generation histamine H1 receptor antagonist that exhibits an inhibitory effect on histamine-mediated upregulation of nerve growth factor (NGF) expression. conjunc...
T76372	TRAF6 peptide
	TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS...
T78221	TRAF6 peptide TFA		E1/E2/E3 Enzyme
	TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde...		E1/E2/E3 Enzyme
T80173	BDS-I		Potassium Channel
	BDS-I, a marine toxin derived from Anemonia sulcata, functions as a selective inhibitor of the potassium channel, specifically targeting Kv3.4. It impedes the Aβ1-42-induced augmentation of Kv3.4 activity, caspase-3 acti...		Potassium Channel
T70073	Fabomotizole dihydrochloride
	Fabomotizole, also known as Afobazole, Obenoxazine and CM346, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant action...
T63346	TRK-IN-18
	TRK-IN-18 is a potent inhibitor of TRK. Among them are promyosin-related kinases (Trks), a family of receptor tyrosine kinases activated by neurotrophic factors, a group of soluble growth factors containing nerve growth ...
T62561	TRK-IN-17
	TRK-IN-17 is a potent inhibitor of TRK. Among them is promyosin-related kinase (Trks), a member of the receptor tyrosine kinase family, which is activated by neurotrophic factors. Neurotrophic factors are a group of solu...
T36903	Rasagiline-13C3 (mesylate)	Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is se...

Compounds

Target: Apoptosis, Raf, Trk receptor, CDK

Target: Others, Trk receptor

Fabomotizole hydrochloride

T4093

Synonym: Afobazole hydrochloride,CM346 hydrochloride

Synonym: RC 33 Hydrochloride,RC-33 Hydrochloride,RC33 Hydrochloride

Synonym: N-Propargyl Caffeamide

Synonym: ACAF-4,ACAF 4

Synonym: KT 5926,KT-5926

Synonym: RN-624,PF 4383119

Target:

Acetylcarnitine arginyl amide

T29598

Synonym: ST-857,acetyl-L-carnitine arginine amide

Target: E1/E2/E3 Enzyme

BDS-I

T80173

Synonym:

Target: Potassium Channel

Fabomotizole dihydrochloride

Rasagiline-13C3 (mesylate)

T36903

Synonym: Rasagiline-13C3 (mesylate)

Target:

Cat No.	Product Name	Synonyms	Targets
T82396	Fissitungfine B
	Fissitungfine B, a chemical compound isolated from the tropical medicinal plant Fissistigma tungfangense, exhibits potent anticancer activity [1].
TQ0218	Deoxyandrographolide	14-deoxyandrographolide	IL Receptor , TNF
	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.		IL Receptor , TNF
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
TN4379	Kansuinine A		IL Receptor , STAT , Interleukin
	Kansuinine A possesses analgesic props, it also shows NGF inducing activity.		IL Receptor , STAT , Interleukin
T81213	Sarbronine M
	Scabronine M, a novel inhibitor, impedes NGF-induced neurite outgrowth from PC12 cells.
T82446	Erinacine C
	Erinacine C, a potent stimulator, promotes the synthesis of nerve-growth factor (NGF) [1].
TN5286	3β,5α,9α-Trihydroxyergosta-7,22-dien-6-one
	3β,5α,9α-Trihydroxy-ergosta-7,22-dien-6-one in the presence of NGF (20 ng/mL) exerts a significant increase in neurite-bearing cells.
T81676	NG-012
	NG-012, a nerve growth factor (NGF) potentiator, was isolated from the culture broth of Penicillium verruculosum F-4542. It enhances neurite outgrowth as induced by NGF in the rat pheochromocytoma cell line (PC12) [1].
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol		MAPK , PKC
	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.		MAPK , PKC
T81980	Kissoone C
	Kissoone C (compound 3), a sesquiterpene with a three-membered ring structure, has been isolated from valerian root. This compound has been found to promote nerve growth factor (NGF)-mediated neurite outgrowth in PC12D c...
TN4126	Gentiside B		Others
	Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) conc...		Others
TMA0984	Cerevisterol		DNA/RNA Synthesis
	Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.		DNA/RNA Synthesis
T81814	Methyl Ganoderic acid B
	Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].
TN4291	Isofuranodiene		IL Receptor , NOS
	Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting...		IL Receptor , NOS

Natural Products

Synonym: 14-deoxyandrographolide

Target: IL Receptor, TNF

Target: AMPK, mTOR, Autophagy

Eudesmin

T3836

Synonym:

Target: MAPK, S6 Kinase

Kansuinine A

TN4379

Synonym:

Target: IL Receptor, STAT, Interleukin

3β,5α,9α-Trihydroxyergosta-7,22-dien-6-one

(2R,3S)-Dihydrodehydroconiferyl alcohol

Target: DNA/RNA Synthesis

Methyl Ganoderic acid B

Target: IL Receptor, NOS

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01010	NGF Protein, Human, Recombinant	Human	CHO Cells
	NGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.2 kDa and the accession number is P01138.
TMPJ-01469	NGF Protein, Human, Recombinant (E. colli)	Mouse	E. coli
	NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family ...
TMPJ-01468	Pro-Beta NGF Protein, Human, Recombinant	Human	E. coli
	The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite...
TMPY-06985	NGF Protein, Human, Recombinant (HEK293)	Human	HEK293 Cells
	NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138.
TMPY-04069	Neurotrophin 3 Protein, Human, Recombinant	Human	E. coli
	NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate...
TMPY-01402	NGF Protein, Mouse, Recombinant	Mouse	CHO Cells
	NGF Protein, Mouse, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P01139.
TMPH-03102	NGF Protein, Pig, Recombinant (His & SUMO)	Sus scrofa (Pig)	E. coli
	NGF Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.4 kDa and the accession number is Q29074.
TMPY-02614	NGFR/p75NTR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is P08138.
TMPY-04831	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is XP_008269543.1.
TMPY-06973	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	NGFR/p75NTR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.03 kDa and the accession number is XP_005583674.1.
TMPY-04646	NGFR/p75NTR Protein, Rabbit, Recombinant (His)	Rabbit	HEK293 Cells
	NGFR/p75NTR Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is XP_008269543.1.
TMPY-02588	NGFR/p75NTR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.6 kDa and the accession number is Q9Z0W1.
TMPY-06959	NGFR/p75NTR Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	NGFR/p75NTR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.34 kDa and the accession number is P07174.
TMPY-02541	NGFR/p75NTR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	NGFR/p75NTR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Z0W1.
TMPY-02615	NGFR/p75NTR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	NGFR/p75NTR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is P08138.
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I...
TMPK-00774	TrkA Protein, Human, Recombinant (aa 33-417, His)	Human	HEK293 Cells
	TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signa...
TMPY-02579	NRN1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervo...
TMPH-01282	ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th...