malt1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2350	MALT1 inhibitor MI-2	MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)	MALT
	MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.		MALT
T73266	NVS-MALT1
	NVS-MALT1 is an allosteric inhibitor of MALT1 [1].
T63053	MALT1-IN-3
	MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.
T62322	(S)-MALT1-IN-5
	(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits MALT1 activity and has the potential to improve the enhancement of MALT1 activity caused by abnormal T-cell receptor signalling or B-cell re...
T63051	(R)-MALT1-IN-3
	(R)-MALT1-IN-3 (compound 121) is a potent inhibitor of MALT1 protease (IC50: 20 nM) with IC50 values of 60 nM and 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively.
T61867	MALT1-IN-9
	MALT1-IN-9 (WO2021000855A1, Compound 5), a highly potent inhibitor of MALT1 protease, demonstrates an IC50 value of <500 nM when tested in Raji MALT1-GloSensor cells. MALT1-IN-9 exhibits significant anticancer properties...
T62323	MALT1-IN-5
	MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.
T63372	MALT1-IN-6
	MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.
T63134	MALT1-IN-7
	MALT1-IN-7 (compound 142b) is a potent inhibitor of MALT1 protease with potential for cancer research.
T62533	MALT1-IN-8
	MALT1-IN-8 is a potent inhibitor of MALT1 protease (IC50: 2 nM). MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells (IC50: 1.16 μM) and exhibits anticancer activity.
T73019	MALT1-IN-11
	MALT1-IN-11, a potent MALT1 protease inhibitor (IC 50 < 10 nM), effectively reduces IL10 secretion, exhibiting an IC 50 between 10-100 nM. This compound is primarily utilized in the study of cancer, autoimmune, and infla...
T63133	(R)-MALT1-IN-7
	(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.
T9216	MLT-943	MLT943	MALT
	MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].		MALT
T16040	Mepazine	Pecazine	Apoptosis , MALT
	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.		Apoptosis , MALT
T36670	JNJ-67856633		MALT
	JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.		MALT
T16119	MLT-747		Others
	MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).		Others
T16120	MLT-748		Others
	MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).		Others
T68994	Mepazine hydrochloride monohydrate
	Mepazine hydrochloride monohydrate is a MALT1 inhibitor.
T39271	MLT-985
	MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC 50 value of 3 nM.
T69634	Mepazine acetate
	Mepazine acetate is a MALT1 inhibitor.
T62680	(R)-MLT-985
	(R)-MLT-985 (compound 11) is a potent inhibitor of MALT1 protease (IC50: 3 nM). (R)-MLT-985 has an IC50 value of 20 nM for MALT1-dependent IL-2 in Jurkat cells.(R)-MLT-985 inhibits growth and aberrant CARD11/BCL10/MALT1 ...
T73389	RGT-068A
	RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .
TP2101	Z-VRPR-FMK trifluoroacetate salt
	Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.
T73093	Z-VRPR-FMK
	Z-VRPR-FMK, an irreversible inhibitor of the MALT1 protein, effectively suppresses the proliferation and invasion of diffuse large B-cell lymphoma. This is achieved through the inhibition of MALT1-induced NF-κB activatio...
TP1014	Z-VRPR-FMK (TFA)	VRPR
	Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible inhibitor of lymphoma translocation protein 1 (MALT1) in mucosa-associated lymphoid tissue.
T76604	Val-Arg-Pro-DL-Arg-Fluoromethylketone
	Val-Arg-Pro-DL-Arg-Fluoromethylketone, a potent MALT1 inhibitor, exhibits anticancer activity by inhibiting cell proliferation and migration [1].
T38096	MLT-231
	MLT-231, a potent and highly selective allosteric MALT1 inhibitor, has an IC50 of 9 nM and specifically inhibits endogenous BCL10 cleavage with an IC50 of 160 nM. It exhibits antitumor activity in an ABC-DLBCL type xenog...
T75938	Z-VRPR-FMK TFA
	Z-VRPR-FMK (TFA), a selective and irreversible inhibitor of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), is a tetrapeptide shown to provide protection against influenza A virus (IAV) infect...
T61153	Mepazine hydrochloride
	Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of the MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. It enhances apoptosis and ...

Compounds

MALT1 inhibitor MI-2

T2350

Synonym: MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)

Target: Apoptosis, MALT

Mepazine hydrochloride monohydrate

Z-VRPR-FMK trifluoroacetate salt

Val-Arg-Pro-DL-Arg-Fluoromethylketone

Mepazine hydrochloride

T61153

Synonym:

Target:

Cat No.	Product Name	Species	Expression System
TMPH-01001	BCL10 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing...

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Recombinant Proteins

Compounds

Recombinant Proteins