limk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72399	LIMK1 inhibitor BMS-4
	LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1/2, specifically inhibiting the phosphorylation of its substrate, cofilin, but it remains noncytotoxic on A549 cells.
T38511	AWL-II-38.3		Ephrin Receptor
	AWL-II-38.3 is a highly effective inhibitor of EphA3, a receptor for ephrin-A. It demonstrates potent kinase inhibitory activity against EphA3 and does not show significant cellular activity against Src-family kinases or...		Ephrin Receptor
T19578	TH-263		Others
	TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.		Others
T7128	TH-257	TH 257	LIM Kinase
	TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).		LIM Kinase
T4598	BMS-5	BMS5,LIMKi 3	LIM Kinase
	BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.		LIM Kinase
T15798	LX7101		ROCK , LIM Kinase , PKA
	LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).		ROCK , LIM Kinase , PKA
T4600	BMS-3		LIM Kinase
	BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.		LIM Kinase
T12609	R-10015		LIM Kinase , Reverse Transcriptase
	R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may ...		LIM Kinase , Reverse Transcriptase
T36680	SM1-71		Serine/threonin kinase , MAPK , LIM Kinase , TGF-beta/Smad , AAK1 (AP2 associated kinase 1)
	SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-7...
T70364	TH251
	TH251 is a highly selective antagonist of LIMK1 and LIMK2 (LIMK1/2).
T73545	TH470
	TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2, making it applicable in orphan disease research.
T75556	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].
T80253	S3 Fragment
	S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the ac...
T68823	SPU-106
	SPU-106 is a novel specific PAK4 inhibitor, effectively inhibiting the invasion of SGC7901 cells without cytotoxicity, regulating the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways.
T74642	DB1113
	DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases. It effectively degrades a range of kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, M...
T74644	DB0614
	DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK...
T26224	SR7826	SR-7826,SR 7826
	SR7826 is a selective LIMK inhibitor.