FQ

FQ is a novel reversible inhibitor of mixed-type tyrosinase.

Orphanin FQ(1-11) TFA, a fragment of orphanin FQ or nociceptin (OFQ/N), acts as a powerful NOP receptor (ORL-1; OP4) agonist with a K i of 55 nM. It lacks affinity for μ, δ, κ1, and κ3 receptors (K i >1000 nM), demonstrating specificity, and exhibits analgesic properties in CD-1 mice [1] [2].

Orphanin FQ(1-11) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM) and displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Orphanin FQ(1-11) displays analgesic properties in CD-1 mice.

Orphanin FQ(1-11) acetate(178249-41-7 free base) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) acetate(178249-41-7 free base) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM) and displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Orphanin FQ(1-11) acetate(178249-41-7 free base) displays analgesic properties in CD-1 mice.

Nociceptin (Orphanin FQ) is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A.

2-Amino-3,4,8-trimethylimidazo4,5-fquinoxaline-D3 is the deuterium-labeled version of 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline.

FQI2-34 is an orally active small-molecule allosteric inhibitor of TFCP2 (LSF). It binds directly to the LSF protein (Ki = 63 nM), inhibits LSF oligomerization, and effectively suppresses LSF transcriptional activity (IC₅₀ = 48 nM), thereby disrupting the SF-DNA interaction. FQI2-34 exhibits significant antiproliferative effects on Huh7 cells and induces tumor regression in mouse models. This compound can be utilized for hepatocellular carcinoma research.

FQI 1 is a selective late-stage SV40 factor (LSF) inhibitor with anticancer activity that exerts its antiproliferative activity by disrupting the mitotic spindle.FQI 1 inhibits the proliferation of NIH/3T3, HeLa, and A549 cells, and can be used in the study of cancers.

FAM-DEALAHypYIPMDDDFQLRSF is a 5,6-carboxyfluorescein (FAM) labeled HIF-1α peptide. It binds with high affinity to von Hippel-Lindau (VHL) protein (KD= 3 nM). Can be used to assess ligand binding to VHL in a direct fluorescence polarization (FP) displacement assay. Excitation/emission maxima (λ) = 485/520 nm. This product is a longer peptide version of FAM-DEALA-Hyp-YIPD.

Cefquinome Sulfate is a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with antibacterial activity.

MLGFFQQPKPR-NH2, a reversed Substance P peptide, is a neuropeptide [1].

Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).

NEt-iFQ, a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties, selectively binds to RXR-LBP and fluoresces [1].

cefquinome Sulfate (Standard) is the standard substance of cefquinome Sulfate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Cefquinome Sulfate is a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with antibacterial activity.

PIYLGGVFQ is a TNF-α peptide inhibitor. It can suppress TNF-α-mediated apoptosis, nuclear translocation, and activation of NF-κB. In a CIA mouse model, PIYLGGVFQ has demonstrated anti-arthritic activity.

FAM-DEALA-Hyp-YIPMDDDFQLRSF-NH2 is a 5-FAM labeled HIF-1α peptide that acts as a substrate for VHL. It binds to the VHL protein with a dissociation constant (KD) of 3 nM. The excitation/emission wavelengths (Ex/Em [λ]) are 485/520 nm.

Biotin-EEENLYFQ-Abu-glycolate-R-amide is a specific substrate for Bacillus subtilis ligase, enabling efficient detection of Bacillus subtilis ligase activity.

IKFQFHFD is a pH-responsive self-assembling peptide. It exhibits biocompatibility at neutral pH and adopts an antimicrobial peptide-like molecular structure only at acidic pH. IKFQFHFD can be used to treat chronic wounds caused by biofilm infections, such as venous ulcers, diabetic ulcers, and pressure sores.

Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.

Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinson’s disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide–alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66996 and the CAS number is 104239-97-6.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67601 and the CAS number is 103335-55-3.

5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist and a potential lead compound for further testing in the drug development process for aging-associated diseases.

BAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.